ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels

article



Neale, M.C.

Knijff, P. de

Havekes, L.M.

Boomsma, D.I.
ApoE levels and chromosome 19 ApoE polymorphisms were measured in a sample of 156 Dutch families. Each pedigree consisted of parents aged 35-65 years and their twin offspring aged 14-21 years. A significant effect of the chromosome 19 apoE locus on quantitative plasma levels of apolipoprotein E was observed. The ApoE polymorphism explained 16% of the variance in ApoE levels. Tests of association of ApoE levels with the apoC1 locus, which is in complete linkage disequilibrium with the ApoE locus, also showed a significant effect, although the variance explained by ApoCl was only 1%. Examination of the covariance between twins classified according to allele sharing indicates that the association is not due to population stratification, but to a genuine effect of the ApoE locus on levels. However, the ApoE locus accounts for only one-fourth of the genetic variation in ApoE levels. (C) 2000 Wiley-Liss, Inc.
Chemicals/CAS: Apolipoproteins E
Topics




















AdolescentAdultAllelesApolipoproteins EChromosomes, Human, Pair 19Enzyme-Linked Immunosorbent AssayFemaleGene FrequencyGenotypeHumansLinkage DisequilibriumMaleMiddle AgedModels, GeneticModels, StatisticalNetherlandsPedigreePhenotypePolymorphism, GeneticTwinsVariation (Genetics)
TNO Identifier
235508
Repository link
https://resolver.tno.nl/uuid:686d406b-05a4-4275-82c2-cb8c787de845
ISSN
07410395
Source
Genetic Epidemiology, 18(4), pp. 331-340.
Pages
331-340
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