IFN-beta modulates specific T cell responses in vitro but does not affect Experimental Autoimmune Encephalomyelitis in the SJL mouse
article
In this study, mouse recombinant IFN-β was shown to favor PLP139-151-specific Th2 responses in vitro, by inhibiting IFN-γ production and stimulating IL-4 and IL-10 production. IFN-β (5000 U/day) failed to prevent the development or severity of EAE induced with PLP139-151. Whereas efficacy of IL-10 was found in the B. pertussis assisted but not in the pertussigen-assisted EAE model, both models appeared insensitive to IFN-β. Also the combination of (suboptimal) IL-10 and IFN-β appeared ineffective in inhibiting disease. However, the PLP139-151-specific IL-10 production by T cells from these mice appeared significantly more sensitive to the stimulatory effect of IFN-β in vitro. It is concluded that despite its Th2 promoting effects, IFN-β is not effective in inhibiting EAE in this study. Copyright (C) 1999 Elsevier Science B.V. Chemicals/CAS: Interferon-beta, 77238-31-4; Interleukin-10, 130068-27-8; Pertussis Toxin, EC 2.4.2.31; Recombinant Proteins; Virulence Factors, Bordetella
Topics
EAEInterferon-βMultiple sclerosisMurineT lymphocyteAnimalsCells, CulturedDose-Response Relationship, DrugEncephalomyelitis, Autoimmune, ExperimentalEnzyme-Linked Immunosorbent AssayFemaleInterferon-betaInterleukin-10LymphocytesMiceMice, Inbred StrainsPertussis ToxinRecombinant ProteinsTh2 CellsTime FactorsVirulence Factors, Bordetella
TNO Identifier
235305
ISSN
01655728
Source
Journal of Neuroimmunology, 100(1-2), pp. 190-196.
Pages
190-196
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