Importance of levonorgestrel dose in oral contraceptives for effects on coagulation
article
Combined oral contraceptives show clear differences in effect on the tissue factor-initiated coagulation test of activated protein C resistance, which is dependent on the presence and dosage of levonorgestrel. Multiphasic levonorgestrol oral contraceptives differ from monophasic contraceptives and resemble third-generation contraceptives. The significance of levonorgestrel dose in oral contraceptives for effects on coagulation is presented. A study in Germany was conducted to test the activated protein C resistance and assess the differences induced by various combined oral contraceptives (COCs). A resistance to activated protein C of monophasic COCs with desogestrel, gestodene, or norgestimate close to the value of women heterozygous for factor V Leiden was confirmed. Higher concentrations of levonorgestrel counteract the increase in resistance. Thus, monophasic and multiphasic COCs with levonogestrel were distinguished according to their effects on tissue-factor-initiated resistance to activated protein C. A more detailed comparison of in-vitro coagulation effects and epidemiology will further assess the plausibility and mechanisms of resistance in relation to activated protein C acquired by COC use and venous thromboembolism. Chemicals/CAS: Contraceptives, Oral, Combined; Contraceptives, Oral, Synthetic; Levonorgestrel, 797-63-7
Topics
Clinical ResearchContraceptionContraceptive Agents, Female--administraction and dosageContraceptive Agents, Progestin--administraction and dosageContraceptive Agents--administraction and dosageContraceptive MethodsDesogestrelDeveloped CountriesDiseasesEmbolismEuropeFamily PlanningGermanyGestodeneLevonorgestrel--administraction and dosageNorgestimateOral ContraceptivesOral Contraceptives, CombinedResearch MethodologyResearch ReportThromboembolismVascular DiseasesWestern EuropeActivated Protein C ResistanceBlood CoagulationContraceptives, Oral, CombinedContraceptives, Oral, SyntheticFemaleHumansLevonorgestrel
TNO Identifier
235152
ISSN
01406736
Source
Lancet, 354(9181), pp. 832-833.
Pages
832-833
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