Determinants of p,p'-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities
article
To identify the determinants of p,p'-dichlorodiphenyldichloroethane (p,p'-DDE) in adipose tissue in subjects who participated in a cross- sectional study, we analyzed fatty acids, antioxidants, and p,p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 μg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log10(p,p'-DDE) were center of recruitment (p < .0001), adipose arachidic acid (p = .001), and adipose retinol (p = .04). These factors explained 14.9% of the overall variability of log10(p,p'-DDE). In our subjects, adipose tissue p,p'-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p,p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.
Topics
1,1 dichloro 2,2 bis(4 chlorophenyl)ethyleneAntioxidantArachidic acidBiological markerFatty acidRetinolAdipose tissueAdultAgedBreast cancerCancer riskCityControlled studyEuropeFemaleFishFood chainFood contaminationFood intakeHumanHuman tissueMajor clinical studyPostmenopausePriority journalRegression analysisTissue levelAdipose TissueAgedAntioxidantsCross-Sectional StudiesDichlorodiphenyl DichloroethyleneDietEnvironmental ExposureEnvironmental MonitoringEuropeFatty AcidsFemaleFood ContaminationHumansInsecticidesLinear ModelsMiddle AgedMultivariate AnalysisPostmenopauseQuestionnairesRisk FactorsUrban Health
TNO Identifier
235079
ISSN
00039896
Source
Archives of Environmental Health, 54(4), pp. 277-283.
Pages
277-283
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