Synthesis of reduced collagen crosslinks

article






Nieuwendijk, A.M.C.H. van den

Benningshof, J.C.J.

Wegmann, V.

Bank, R.A.

Koppele, J.M. te

Brussee, J.

Gen, A. van der
A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis.
Topics

















CollagenAlkylationChemical reactionChemical structureCross linkingDiastereoisomerHydrogenationProtein synthesisReaction analysisAlkylationCollagenCross-Linking ReagentsDipeptidesHumansMagnetic Resonance SpectroscopyMass SpectrometryOxidation-ReductionStereoisomerism
TNO Identifier
235067
Repository link
https://resolver.tno.nl/uuid:50d2acad-8b12-4b37-9624-52407611ee76
ISSN
0960894X
Source
Bioorganic and Medicinal Chemistry Letters, 9(12), pp. 1673-1676.
Pages
1673-1676
Files
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