Effects of long term feeding of raw soya bean flour on virus- induced pancreatic carcinogenesis in guinea fowl
article
The effects of a diet enriched with 25% raw soya bean flour (RSF) on the pancreas and on the avian retrovirus Pts 56-induced pancreatic carcinogenesis in guinea fowl were studied. It has been shown that prolonged RSF feeding of new-hatched virus-infected and uninfected guinea fowl-poults induced enlargement of the pancreas, which was less pronounced when administration of the RSF supplemented diet started at the age of 75 days. Time-dependent multifocal inter- and intralobular hyperplasia of pleomorphic ducts lined by mucin-producing epithelium in the exocrine pancreas of virus-infected guinea fowls fed a RSF supplemented diet was regularly observed. Enlargement of virus-induced ductular neoplasms has been shown only after simultaneous RSF and virus administration. Copyright (C) 1999 Elsevier Science Ireland Ltd.
Topics
Guinea fowlPancreatic carcinogenesisRaw soya bean flourBirdCarcinogenesisDietHistologyMicroscopyPancreas cancerPriority journalRetrovirusSoybeanVirus infectionAnimalsAnimals, NewbornBody WeightCarcinogenicity TestsCocarcinogenesisFemaleFlourHyperplasiaMalePancreasPancreatic DuctsPancreatic NeoplasmsPoultryRandom AllocationRetroviridaeRetroviridae InfectionsSoybeansTumor Virus Infections
TNO Identifier
234924
ISSN
03043835
Source
Cancer Letters, 135(2), pp. 195-202.
Pages
195-202
Files
To receive the publication files, please send an e-mail request to TNO Repository.