The mechanism of N-acetylcysteine photoprotection is not related to dipyrimidine photoproducts

article




Nijmeijer, B.A.

Steenvoorden, D.P.T.

Beijersbergen Van Henegouwen, G.M.J.

Roza, L.

Vink, A.A.
Topical application of N-acetylcysteine prior to UVB irradiation of BALB/c mice has previously been shown to inhibit systemic suppression of the contact hypersensitivity response. Formation of cis-urocanic acid, however, is not affected. Besides urocanic acid, UV-induced DNA damage has been held responsible for the initiation of suppression of the contact hypersensitivity response. Therefore, the possible inhibitory effect of N-acetylcysteine on UVB-induced cyclobutane pyrimidine dimers and pyrimidine (6-4) pyrimidone photoproducts has been investigated. No effect on the photoproducts studied is observed, suggesting that N-acetylcysteine exerts its photoprotective effect during the post-initiation phase of photoimmunosuppression.
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DNA damageImmunosuppressionPhotoprotectionAcetylcysteineCyclobutanePyrimidine dimerUrocanic acidAnimal experimentContact allergyDna damageMouseNonhumanPriority journalUltraviolet b radiationAcetylcysteineAnimalsDNA DamageEpidermisGlutathioneMaleMiceMice, Inbred BALB CPyrimidinesUltraviolet RaysAnimalia
TNO Identifier
234549
Repository link
https://resolver.tno.nl/uuid:cd5daf7a-edee-4c95-b5be-4698ac1ec891
ISSN
10111344
Source
Journal of Photochemistry and Photobiology B: Biology, 44(3), pp. 225-230.
Pages
225-230
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