Space-time clustering of multiple sclerosis cases around birth

article




Buuren, S. van

Zaadstra, B.M.

Zwanikken, C.P.

Buljevac, D.

Noort, J.M. van
Objectives - To investigate whether infectious events around birth and during early infancy are likely to be of relevance in MS pathogenesis. Subjects and methods - Data are available from two regions in The Netherlands: Groningen (n=320) and Rotterdam (n=226). Simultaneous clustering in birth date and birth location of MS cases is tested by the methods of Mantel, Knox and Jacquez. Results - No evidence was found for a space-time interaction between place and time of birth. Conclusion - Perinatal infectious events are unlikely to be a major factor in determining MS susceptibility.
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Computerized medical records systemInfectious pregnancy complicationsMultiple sclerosisPuerperal infectionSpace-time clusteringAge DistributionChildChild, PreschoolDisease OutbreaksFemaleHumansInfantInfant, NewbornInfectionMultiple SclerosisNetherlandsSpace-Time Clustering
TNO Identifier
234511
Repository link
https://resolver.tno.nl/uuid:473398fe-ea4d-494c-8269-163f32d51389
ISSN
00016314
Source
Acta Neurologica Scandinavica, 97(6), pp. 351-358.
Pages
351-358
Files
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