Subchronic physostigmine pretreatment in guinea pigs: Effective against soman and without side effects
article
The behavioral and neurophysiological effects of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic antagonist scopolamine (SCO) (0.018 mg/kg/h) were determined in guinea pigs. In contrast to a single injection of PHY, subchronic application by osmotic minipumps of PHY, even without SCO, caused no behavioral or neurophysiological side effects. Also, the efficacy of such a pretreatment in counteracting soman-induced lethality and apparent symptoms of intoxication were determined. After subchronically administered PHY or PHY + SCO, the treated animals were protected against a 3 x LD(50) dose of soman.
Topics
BehaviorCholinesteraseElectrophysiologyGuinea pigMuscarinergic receptorPhysostigminePretreatmentScopolamine 51-34-3Soman 96-64-0SubchronicChemical warfare agentCholinesterase inhibitorPhysostigmine 57-47-6Drug delivery systemDrug effectDrug efficacyDrug intoxicationMaleNeurotoxicitySubcutaneous drug administrationAcetylcholinesterase, EC 3.1.1.7AnimalsAvoidance LearningElectroencephalographyElectrophysiologyEvoked Potentials, VisualMuscarinic AntagonistsReceptors, CholinergicReceptors, MuscarinicStartle ReactionCaviaCavia porcellusSus scrofa
TNO Identifier
234424
ISSN
0091-3057
Source
Pharmacology Biochemistry and Behavior, 59(4), pp. 1061-1067.
Pages
1061-1067
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