Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism: Differences between older men and women
article
Coagulation factor VII activity (FVII:C) is a risk indicator for cardiovascular disease. It is related to serum-triglycerides and the R/Q353 polymorphism (alleles R and Q) in the gene coding for factor VII is strongly associated with factor VU[. The association of serum-triglycerides with factor VII may differ between the genotypes, but the results of earlier studies were inconsistent and did not include older people. We studied FVII, triglycerides and the R/Q353 polymorphism in the Rotterdam Study. In 1158 older subjects (489 men and 669 women) FVII:C, factor VII:Chr, serum-triglycerides and the R/Q353-genotype were determined. In women triglycerides were positively associated with FVII:Chr and FVII:C (FVII:Chr: β = 12.4% PP/mmol/L, CI: 10.3-14.5; FVII:C: β = 13.1% PP/mmol/L, CI: 10.4-15.8). These associations varied by genotype (FVII:Chr:RR: β = 11.7, CI: 9.6-13.8, RQ/QQ: β = 7.9, CI: 4.6-11.2; FRII:C: RR: β = 12.5, CI: 9.5-15.5, RQ/QQ: β = 6.4, CI: In men, the associations of FVII:Chr and FVII:C with triglycerides were weaker (FVII:Chr: β = 5.9, CI: 4.1-7.7; FVII:C: β = 8.7, CI: 6.2-11.2). There was no difference between the genotype groups. These results suggest that only in older women the strength of the association of factor VII with serum-triglycerides varies according to genotype of the R/Q353 polymorphism.
Topics
Blood clotting factor 7TriacylglycerolAdultAgedAlleleCardiovascular riskControlled studyGenetic associationGenetic polymorphismGenotypeHuman cellMajor clinical studyRegression analysisSex differenceTriacylglycerol blood levelAgingAllelesFactor VIIFemaleGenotypeHumansMaleMiddle AgedPolymorphism, GeneticSex CharacteristicsTriglycerides
TNO Identifier
234018
ISSN
03406245
Source
Thrombosis and Haemostasis, 78(3), pp. 984-986.
Pages
984-986
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