Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling

Hissink, E.; Ommen, B. van; Bogaards, J.J.; Bladeren, P.J. van

Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling

article

1996

Hissink, E.

Ommen, B. van

Bogaards, J.J.

Bladeren, P.J. van

Topics

1,2 Dichlorobenzene 1,4 Dichlorobenzene Alanine aminotransferase Ascorbic acid Cytochrome p450 isoenzyme Epoxide Glutathione Isoniazid Animal cell Animal experiment Animal model Biotransformation Conference paper Controlled study Detoxification Enzyme substrate Liver microsome Liver toxicity Male Mathematical model Nonhuman Priority journal Rat Toxicokinetics Animals Biotransformation Carcinogens Chlorobenzenes Cytochrome P-450 Enzyme System Epoxy Compounds Humans Liver Male Microsomes, Liver Models, Biological Rats Rats, Wistar

TNO Identifier

233427

Repository link

https://resolver.tno.nl/uuid:cd8f7ef2-0662-4e3d-8f4e-4bb5eb202acd

ISSN

00652598

Source

Advances in Experimental Medicine and Biology, 387, pp. 129-134.

Pages

129-134

Files

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Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling

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