Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma
article
Proteinases are involved in tumour invasion and metastasis. Several matrix metalloproteinases (MMPs) have been shown to be increased in various human carcinomas. We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography. Both MMP levels were significantly enhanced in gastric carcinomas compared with adjacent mucosal tissue, showed a relatively poor intercorrelation and no relation was found with histopathological carcinoma classifications according to Lauren, WHO and tumour-node-metastasis (TNM). Cox's multivariate proportional hazards analyses revealed that high carcinomatous MMP values are of prognostic significance for a poor overall survival of the patients, independent of the major clinicopathological parameters. Chemicals/CAS: Collagenases, EC 3.4.24.-; Gelatinases, EC 3.4.24.-; Matrix Metalloproteinase 2, EC 3.4.24.24; Matrix Metalloproteinase 9, EC 3.4.24.35; Metalloendopeptidases, EC 3.4.24.-
Topics
Gastric carcinomaGelatinasesMatrix metalloproteinaseQuantitative zymographygelatinase bproteinaseadultcancer classificationcancer invasioncancer survivalclinical articlecontrolled studyhistopathologyhuman tissuemetastasispriority journalprognosisstomach carcinomastomach mucosaAgedCollagenasesFemaleGelatinasesHumansMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9MetalloendopeptidasesMiddle AgedStomach NeoplasmsSurvival Rate
TNO Identifier
233424
ISSN
00070920
Source
British Journal of Cancer, 74(3), pp. 413-417.
Pages
413-417