Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease

article





Bronzova, J.

Duijn, C.M. van

Havekes, L.M.

Knijff, P. de

Broeckhoven, C. van

Hofman, A.
We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the ε4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.
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Apolipoprotein E geneApolipoprotein eApolipoprotein e4AdultAlleleClinical featureDisease courseGenotypeMajor clinical studyMyoclonusRigidityRiskSeizureTremorAllelesAlzheimer DiseaseApolipoproteinsFemaleHumansMaleMiddle AgedPrognosis
TNO Identifier
233367
Repository link
https://resolver.tno.nl/uuid:8b688a92-bf16-43f5-b34b-5795d0b33978
ISSN
03405354
Source
Journal of Neurology, 243(6), pp. 465-468.
Pages
465-468
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