Correlation between the antibody response to influenza vaccine and helper T cell subsets in healthy ageing

article





Remarque, E.J.

Nijhuis, E.W.P.

Hinloopen, B.

Nagelkerken, L.

Velde, E.A. van der

Ligthart, G.J.
To investigate the effects of the altered composition of the helper T cell compartment in ageing on the humoral response to influenza vaccine, we investigated correlations between helper T cell subsets and anti-influenza antibody responses in 23 JUNIEUR healthy young and 41 SENIEUR healthy elderly subjects. Naive helper T cell numbers (CD4+CD45RA+) were negatively correlated with antibody production to two of the four strains investigated in JUNIEURS only. By contrast, memory helper T cell numbers (CD4+CD45RO(hi)) were positively correlated with in vivo IgG antibody titres to three of the four vaccine strains. Age-related differences in the composition of the helper T cell compartment, however; did not explain the lower IgG antibody response that was observed to two of the four vaccine strains examined.
Topics

















AgeingCD4+ T cellsHumoral immune responseInfluenzaAdultAgedAged, 80 and overAgingAntibodies, ViralAntibody FormationHumansImmunoglobulin IsotypesInfluenza VaccinesLymphocyte ActivationMiddle AgedRegression AnalysisT-Lymphocyte SubsetsT-Lymphocytes, Helper-Inducer
TNO Identifier
233204
Repository link
https://resolver.tno.nl/uuid:d9eab3c8-f4d7-4d82-a743-8e83c2789fff
ISSN
0264410X
Source
Vaccine, 14(2), pp. 127-130.
Pages
127-130
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