Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus

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Myrup, B.

Hansen, P.M.

Jensen, T.

Kofoed-Enevoldsen, A.

Feldt-Rasmussen, B.

Gram, J.

Kluft, C.

Jespersen, J.

Deckert, T.
We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.
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albuminheparinisotonic solutionsodium chlorideadultclinical articleclinical trialcontrolled clinical trialcontrolled studyfemalehumaninsulin dependent diabetes mellitusproteinuriarandomized controlled trialsubcutaneous drug administrationAdultAlbuminuriaDiabetes Mellitus, Type 1FemaleHeparinHeparin, Low-Molecular-WeightHumansMaleMiddle AgedTreatment Outcome
TNO Identifier
232953
Repository link
https://resolver.tno.nl/uuid:9354f6e3-e6c4-4428-9e70-0315cd926c6c
ISSN
01406736
Source
Lancet, 345(8947), pp. 421-422.
Pages
421-422
Files
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