Akv murine leukemia virus enhances bone tumorigenesis in hMT-c-fos-LTR transgenic mice
article
hMt-c-fos-LTR transgenic mice (U. Ruther, D. Komitowski, F.R. Schubert, and E.F. Wagner. Oncogene 4, 861-865, 1989) developed bone sarcomas in 20% (3/15) of females at 448±25 days and in 8% (1/12) of males at 523 days. After infection of newborns with Akv, an infectious retrovirus derived from the ecotropic provirus of the AKR mouse, 69% (20/28) of female animals and 83% (24/29) of males developed malignant fibrous-osseous tumors. The tumors in infected transgenics developed with higher frequency and a 200-days shorter mean tumor latency period. The hMt-c-fos-LTR transgene was expressed in all the fibrous-osseous tumors. They also showed newly integrated Akv proviruses, but in most tumors Akv was detected and expressed in only a small number of the tumor cells. Wild-type C3H mice infected with Akv developed benign osteomas with an incidence of 33% and a latency period of 474 days. The data indicate that Akv exerts distinct pathogenic effects on the skeleton. In hMt-c-fos-LTR transgenic mice, predisposed to bone sarcomagenesis, Akv acts synergistically with the fos transgene, resulting in the development of fibrous-osseous tumors. Chemicals/CAS: DNA Primers.
Topics
animal experimentarticlecarcinogenesiscontrolled studyfemalemalemousemurine leukemia virusnonhumanosteosarcomapriority journalsex differencetransgenic mouseAKR murine leukemia virusAnimalBase SequenceBone NeoplasmsDNA PrimersFemaleGenes, fosMaleMiceMice, Inbred C3HMice, TransgenicMolecular Sequence DataRepetitive Sequences, Nucleic AcidSarcoma, ExperimentalSupport, Non-U.S. Gov'tTumor Virus InfectionsAKV murine leukemia virusAnimaliaEcotropic provirusMurinaeMurine leukemia virusMus musculusunidentified retrovirus
TNO Identifier
232947
ISSN
00426822
Source
Virology, 206(1), pp. 85-92.
Pages
85-92
Files
To receive the publication files, please send an e-mail request to TNO Repository.