Role of vitamin A in liver fibrosis
article
The relationship between vitamin A and liver fibrosis was studied with a CCl4-induced fibrosis model in rats. Depending on the time of administration, vitamin A can potentiate or reduce fibrosis: when present during CCl4-treatment parenchymal cell damage and fibrosis were enhanced, whereas vitamin A post-treatment strongly reduced fibrosis. Enhanced fibrosis was also found in rats with low hepatic retinoid levels. Administration of β-carotene during CCl4-treatment reduced several signs of fibrosis. The notion that liver retinoids play an important role in hepatic fibrogenesis is discussed.
Chemicals/CAS: beta carotene, 7235-40-7; carbon tetrachloride, 56-23-5; retinol, 68-26-8, 82445-97-4; Antioxidants; beta Carotene, 7235-40-7; Carbon Tetrachloride, 56-23-5; Carotenoids, 36-88-4; Vitamin A, 11103-57-4
Chemicals/CAS: beta carotene, 7235-40-7; carbon tetrachloride, 56-23-5; retinol, 68-26-8, 82445-97-4; Antioxidants; beta Carotene, 7235-40-7; Carbon Tetrachloride, 56-23-5; Carotenoids, 36-88-4; Vitamin A, 11103-57-4
Topics
β-CaroteneCCl4CirrhosisCollagen metabolismFat-storing cellsFibrogenesisFibrosisbeta carotenecarbon tetrachlorideretinolanimal modelconference papercontrolled studynonhumanretinol deficiencyretinol intoxicationAnimalAntioxidantsbeta CaroteneCarbon TetrachlorideCarotenoidsFemaleLiver Cirrhosis, ExperimentalRatsVitamin A
TNO Identifier
232840
ISSN
08159319
Source
Journal of Gastroenterology and Hepatology, 10(SUPPL. 1), pp. S47-S49.
Pages
S47-S49
Files
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