Live bacterial delivery systems for development of mucosal vaccines
article
By expression of foreign antigens in attenuated strains derived from bacterial pathogens and in non-pathogenic commensal bacteria, recombinant vaccines are being developed that aim to stimulate mucosal immunity. Recent advances in the pathogenesis and molecular biology of these bacteria have allowed rational development of new and improved bacterial carriers and more effective gene expression systems. These advances have improved the performance and versatility of these delivery systems to induce mucosal immunity to recombinant antigens in animal models. Application of these (improved) technologies for development of human vaccines is still limited and awaits further exploration Chemicals/CAS: BCG Vaccine; Vaccines, Attenuated; Vaccines, Synthetic
Topics
Attenuated bacteriaCommensal bacteriaGene expression systemMucosal immunityMucosal vaccinesOral vaccinesDrug carrierRecombinant vaccineVaccineAntigen expressionBacteriumDrug delivery systemDrug researchGene expression systemImmune responseLactic acid bacteriumLactobacillusLactococcus lactisMucosaMycobacteriumReviewSalmonellaStaphylococcus carnosusStreptococcus gordoniiVibrio choleraeAnimalsBacteriaBCG VaccineDrug Delivery SystemsGenetic VectorsHumansImmunity, MucosalLactobacillusLactococcus lactisSalmonellaStaphylococcusStreptococcusVaccines, AttenuatedVaccines, SyntheticVibrio choleraeAnimaliaBacteria (microorganisms)Lactobacillus mucosaeLactococcus lactisMycobacteriumSalmonellaStaphylococcus carnosusStreptococcus gordoniiVibrio cholerae
TNO Identifier
88907
ISSN
14648431
Source
Current Opinion in Molecular Therapeutics, 2(1), pp. 94-99.
Pages
94-99
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