Nuclear factor-kB activation is higher in peripheral blood mononuclear cells of male smokers
article
Nuclear factor-κB (NF-κB) is an oxidative stress sensitive transcription factor involved in the regulation of inflammatory genes. Activation of NF-κB results into increased expression of inflammatory genes such as for interleukins, endothelial cell leukocyte adhesion molecules and inducible NO synthase. Our study, with six smokers and 10 non-smokers, showed that NF-κB activity in peripheral blood mononuclear cells of smokers compared to non-smokers is significantly higher (P < 0.05). This indicates that NF-κB is involved in cigarette smoke induced inflammatory responses and that NF-κB activation can be used as a functional marker of oxidative stress. © 2001 Elsevier Science B.V.
TNO Identifier
72248
ISSN
13826689
Source
Environmental Toxicology and Pharmacology, 9(4), pp. 147-151.
Pages
147-151
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