Attenuation of malaria infection, paralysis and lesions in the central nervous system by low protein diets in rats
article
Young Wistar rats developed a fulminant infection when inoculated with the rodent malaria parasite Plasmodium berghei. Rats that died during the infection exhibited a progressive paralysis of the extremities, a rapidly decreasing body temperature and minute haemorrhages in the brain. Increasing the level of protein in the diet from 4 to 8 and 16% was accompanied by an increase in morbidity and mortality from 15 to 40 and 90% respectively on day 6 of the infection. Increasing the level of dietary protein also increased the reticulocyte count of the peripheral blood in infected and non-infected rats. The attenuation of the cerebral syndrome in rats fed a diet low in protein may be related to changes in erythropoiesis or to changes in immune reactivity. Chemicals/CAS: Dietary Proteins
Topics
ZoologyMedicineGeneeskundeHealthGezondheidDieteticsVoedingsleerPathologyAnimalBody TemperatureBrainCerebellumCerebral HemorrhageDietary ProteinsErythrocyte CountErythropoiesisMalariaMalaria, CerebralMaleMorbidityParalysisPlasmodium bergheiRatsRats, Inbred StrainsReticulocytesSupport, Non-U.S. Gov'tWeight GainAnimaliaPlasmodium berghei
TNO Identifier
64003
ISSN
0001706X
Source
Acta Tropica, 50(4), pp. 285-293.
Pages
285-293
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