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Leenheers, L.H. (author), van Breugel, D.C. (author), Ravensberg, J.C. (author), Meuling, W.J.A. (author), Jongen, M.J.M. (author), Medisch Biologisch Laboratorium TNO (author)An analytical method for the assessment of the exposure of workers to the pesticide propoxur through biological monitoring has been developed. This study was part of a survey of occupational exposure to pesticides used in greenhouses for the growing of ornamental plants. In order to assess the actual absorbed amount of propoxur in the body, an...article 1992
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van de Water, H.P.A. (author), Bijleveld, C.C.J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)Eind 1990 verschenen in dit tijdschrift twee artikelen over het aantal met HIV geïnfecteerden in Nederland. Hieruit bleek dat het aantal HIV-seropositieven lager lag dan eerder werd aangenomen, maar dat desondanks een stijgend aantal AIDS-patiënten verwacht mocht worden. In uitkomsten liepen de twee onderzoeken niet ver uiteen. Jager et al....article 1992
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van Loon, A.A.W.M. (author), Raadsheer, F.C. (author), Timmerman, A.J. (author), Haanen, C. (author), Wessels, J. (author), van der Schans, G.P. (author), Lohmans, P.H.M. (author), Baan, R.A. (author), Medisch Biologisch Laboratorium TNO (author)Chemotherapy combined with total-body irradiation (TBI), a conditioning regimen for bone-marrow transplantation (BMT), causes lesions in the cellular DNA of the patients treated. To understand possible consequences of the DNA damage induced during such treatment, information is required about the nature of the damage, the level of induction and...article 1992
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Meijer, W.J. (author), Verloove-Vanhorick, S.P. (author), Brand, R. (author), van den Brande, J.L. (author), TNO Preventie en Gezondheid (author)In 563 surviving very preterm (<32 weeks gestational age) and/or very low birthweight (<1500 g) infants the relationship between neonatal thyroxine concentration and psychomotor development at 2 years of age (corrected for preterm birth) was studied. A significant association was found between low neonatal thyroxine concentration and a negative...article 1992
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Theeuwes, J. (author)Three visual-search experiments tested whether the preattentive parallel stage can selectively guide the attentive stage to a particular known-to-be-relevant target feature. Subjects searched multielement displays for a salient green circle that had a unique form when surrounded by green nontarget squares or had a unique color when surrounded by...article 1992
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Schaapveld, K. (author), van de Water, H.P.A. (author), Bergsma, E.W. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)In the last few years prevention has again become the focus of attention because of various international developments such as the WHO strategy for Health for All by the year 2000. When resources are scarce, it is all the more important to set priorities. This applies to prevention as well as to curative care. In this paper, we describe a method...article 1992
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Instituut CIVO-Toxicologie en Voeding TNO (author), Bogaards, J.J.P. (author), van Ommen, B. (author), van Bladeren, P.J. (author)Eight dimeric isoenzymes of glutathione S-transferase (GST) were purified from liver, kidney and testis of the Syrian golden hamster, using S-hexylglutathione affinity chromatography and chromatofocusing. The isoenzymes were characterized according to their substrate selectivity, physical properties and amino acid sequence analysis. Thus a...article 1992
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van Delft, J.H.M. (author), van den Ende, A.M.C. (author), Keizer, H.J. (author), Ouwerkerk, J. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author)An ELISA method was used to determine N7-methylguanine (N7-MeGua) adducts in DNA of white blood cells from cancer patients treated with the methylating antitumor drug dacarbazine by i.v. administration. From four patients who received dacarbazine only, at dosages of 250, 400 or 800 mg/m2, the blood samples were collected before and several days...article 1992
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Centraal Instituut voor Voedingsonderzoek TNO (author), van Poppel, G. (author), Kok, F.J. (author), Hermus, R.J.J. (author)beta-carotene has been hypothesised to reduce lung cancer risk. We studied the effect of 14 weeks of beta-carotene supplementation (20 mg d-1) on the frequency of micronuclei in sputum in 114 heavy smokers in a double-blind trial. Micronuclei reflect DNA damage in exfoliated cells and may thus provide a marker early-stage carcinogenesis. Pre...article 1992
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Medisch Biologisch Laboratorium TNO (author), de Kort, W.L.A.M. (author), Post Uiterweer, H.W. (author), van Dijk, F.J.H. (author)Five experienced occupational physicians independently reviewed the uniformly structured, concise records of 180 applicants who had applied for a job in one of three categories. All had undergone a pre-employment medical examination by the Governmental Occupational Health and Safety Service. Agreement was assessed by calculating the percentage...article 1992
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- Instituut CIVO-Toxicologie en Voeding TNO (author), van Faassen, A. (author), van 't Veer, P. (author), Bausch-Goldbohm, R.A. (author), Sturmans, F. (author), Hermus, R.J.J. (author) article 1992
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Treurniet, H.F. (author), Davidse, W. (author), TNO Preventie en Gezondheid (author)In 1983 werd door de Geneeskundige Hoofdinspectie (GHI) een landelijke registratie van seksueel overdraagbare aandoeningen (SOA's) ingevoerd, naast het registratiesysteem van wettelijk aangifteplichtige ziekten. De gegevens voor de registratie worden door sociaal-verpleegkundigen, werkzaam bij GGD'en en geslachtsziekten-poliklinieken, verzameld....article 1993
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Lotens, W.A. (author), Wammes, L.J.A. (author)An experiment was carried out to measure the vapour resistance of two-layer clothing ensembles as a function of air permeability of the outer layer, open or closed apertures, wind, and walking, both for the total ensemble and for the outer garment alone. Six subjects walked on a treadmill (0.0, 2.5, and 5 km.h-1) which was placed in a wind...article 1993
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Qvigstad, E. (author), Verloove-Vanhorick, S.P. (author), Ens-Dokkum, M.H. (author), Schreuder, A.M. (author), Veen, S. (author), Brand, R. (author), Oostdijk, W. (author), Ruys, J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)To predict height at five years in a cohort of 565 very preterm and/or very low-birth-weight children, hypothesized growth determinants were subjected to discriminant analysis. Many neonatal parameters were not significantly associated with short stature at five years of age. A correct classification of stature (smaller/larger than the 10th...article 1993
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Koopman, J. (author), Haverkate, F. (author), Grimbergen, J. (author), Lord, S.T. (author), Mosesson, M.W. (author), DiOrio, J.P. (author), Siebenlist, K.S. (author), Legrand, C. (author), Soria, J. (author), Soria, C. (author), Caen, J.P. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author)The molecular defect in the abnormal fibrinogen Dusart (Paris V) that is associated with thrombophilia was determined by sequence analysis of genomic DNA that had been amplified using the polymerase chain reaction. The propositus was heterozygous for a single base change (C → T) in the Aα- chain gene, resulting in the amino acid substitution Aα...article 1993
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- Reerink, J.D. (author), Herngreen, W.P. (author), Verkerk, P.H. (author), Ruys, J.H. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author) article 1993
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Verkerk, P.H. (author), Derksen-Lubsen, G. (author), Vulsma, T. (author), Loeber, J.G. (author), de Vijlder, J.J.M. (author), Verbrugge, H.P. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)Doel. Evaluatie van de Nederlandse screening op congenitale hypothyreoïdie (CHT). Opzet. Descriptief. Plaats. Landelijk. Methoden. Gegevens over de screening in de periode 1 januari 1981-31 december 1990 werden verkregen van de entadministraties, van laboratoria en van kinderartsen naar wie kinderen met afwijkende uitslagen verwezen werden....article 1993
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Verrips, G.H. (author), Kalsbeek, H. (author), Eijkman, M.A. (author), TNO Preventie en Gezondheid (author)The aim of this study was to assess differences in dental health between socioeconomic and ethnic groups in a cohort of 5-yr-old children born in 1982 and in a cohort of 11-yr-old children born in 1976. A further aim was to evaluate the putative role of dental behaviors as intervening factors between ethnicity and maternal education on the one...article 1993
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- Hirasing, R.A. (author), Schaapveld, K. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author) article 1993
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- Vogels, T. (author), van der Vliet, R. (author), Danz, M. (author), Hopman-Rock, M. (author), Visser, A. (author), TNO Preventie en Gezondheid (author) article 1993
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