(81 - 100 of 437)
- document
-
D'Angelo, A. (author), Kluft, C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinolytic system. The shut-down...article 1985
- document
-
Gaillard, A.W.K. (author), Perdok, J. (author), Instituut voor Zintuigfysiologie TNO (author)Slow brain potentials were recorded during the foreperiod of a reaction time task, and the effects of instructions governing the trade-off between speed and accuracy were investigated. One brain potential, a slow negative shift preceding S2, was largely attenuated under accuracy instructions. It is suggested that this shift is dependent on a...article 1980
- document
-
Daanen, H.A.M. (author), van Ling, S. (author), Tan, T.K. (author)Background: It has been shown that endurance performance after one night of sleep deprivation is not compromised despite the feeling of fatigue and that, in contrast, performance in the heat deteriorates even though people may feel good. However, it is essentially unknown how the estimation of performance capabilities relate to actual...article 2013
- document
-
Schmidt, S.C. (author), Sleddens, E.F.C. (author), de Vries, S.I. (author), Gubbels, J. (author), Thijs, C. (author)Changes in the neighborhood environment may explain part of the rapid increase in childhood overweight and obesity during the last decades. To date few theory-driven rather than data-driven studies have explored longitudinal associations between multiple neighborhood characteristics and child body weight development. We aimed to assess the...article 2015
- document
-
Kalsbeek, H. (author), Verrips, G.H. (author), TNO Preventie en Gezondheid (author)Data in a WHO report relating caries prevalence and the use of fluorides in different European countries were compared with data obtained directly from investigators in the field of oral epidemiology. The reliability of DMFT indices of 12-year-old children, mentioned in the WHO report, appeared sufficient to make comparisons between countries on...article 1990
- document
-
Theeuwes, J. (author)Three visual search experiments tested whether top-down selectivity toward particular stimulus dimensions is possible during preattentive parallel search. Subjects viewed multielement displays in which two salient items, each unique in a different dimension—that is, color and intensity (Experiment 1) or color and form (Experiments 2 and 3)—were...article 1991
- document
-
Bots, M.L. (author), van der Bom, J.G. (author), Haverkate, F. (author), Meijer, P. (author), Hofman, A. (author), Grobbee, D.E. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)Background and objective. A low activated protein C (APC) response increases the risk of venous thrombosis, and possibly arterial disease. Apart from the factor V Leiden mutation, other factors may determine the level of APC response. In most studies on the association with arterial disease, cardiovascular risk factors were not appropriately...article 1996
- document
-
Fichtinger-Schepman, A.M.J. (author), Velde van der - Visser, S.D. (author), Dijk van - Knijnenburg, H.C.M. (author), van Oosterom, A.T. (author), Baan, R.A. (author), Berends, F. (author), TNO Voeding Medisch biologisch laboratorium TNO (author)During chemotherapy with a cisplatin-containing combination of drugs, 217 blood samples from 30 cancer patients were analyzed for the presence of the main cisplatin-DNA adduct cis-Pt(NH3)2d(pGpG) (Pt-GG). Cisplatin was administered during 3-h infusions on each of 5 consecutive days, resulting in increasing adduct levels which, on the average,...article 1990
- document
-
de Lange, A.H. (author), Taris, T.W. (author), Kompier, M.A.J. (author), Houtman, I.L.D. (author), Bongers, P.M. (author)This study addressed the methodological quality of longitudinal research examining R. Karasek and T. Theorell's (1990) demand-control-(support) model and reviewed the results of the best of this research. Five criteria for evaluating methodological quality were used: type of design, length of time lags, quality of measures, method of analysis,...article 2003
- document
-
Hirasing, R.A. (author), Donckerwolcke, R.A.M.G. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)Om een indruk te krijgen van de wijze van bloeddrukmeting en de criteria voor het stellen van de diagnose hypertensie in de praktijk van de jeugdgezondheidszorg werd in 1989 een schriftelijke enquête gehouden onder een aselecte steekproef van 100 schoolartsen. De respons bedroeg 62. De resultaten lieten grote verschillen in zowel methoden van...article 1991
- document
- Reerink, J.D. (author), Herngreen, W.P. (author), Verkerk, P.H. (author), Ruys, J.H. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author) article 1993
- document
-
Goldbohm, R.A. (author), Brants, H.A.M. (author), Hulshof, K.F.A.M. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This study presents data on dietary intake of specific carotenoids in the Netherlands, based on a recently developed food composition database for carotenoids. Regularly eaten vegetables, the main dietary source of carotenoids, were sampled comprehensively and analysed with modern analytic methods. The database was complemented with data from...article 1998
- document
-
Voskuil, D.W. (author), Kampman, E. (author), van Kraats, A.A. (author), Balder, H.F. (author), van Muijen, G.N.P. (author), Goldbohm, R.A. (author), van 't Veer, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Epidemiological studies have suggested that dietary factors may differently affect p53-dependent and p53-independent pathways to colon cancer. Results of such studies may depend on the method used to assess p53 status. This case-control study of 185 colon-cancer cases and 259 controls examines this relation, using both immunohistochemistry and...article 1999
- document
-
Cashman, J.R. (author), Xiong, Y. (author), Lin, J. (author), Verhagen, H. (author), van Poppel, G. (author), van Bladeren, P.J. (author), Larsen-Su, S. (author), Williams, D.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The effect of consumption of glucosinolate-containing Brussels sprouts on flavin-containing monooxygenase functional activity in humans was investigated in 10 healthy, male, non-smoking volunteers. After a 3-week run-in period, 5 volunteers continued on a glucosinolate-free diet for 3 weeks (control group), and 5 others consumed 300 g of cooked...article 1999
- document
-
Hoppe, P.P. (author), Krämer, K. (author), van den Berg, H. (author), Steenge, G. (author), van Vliet, T. (author), TNO Voeding (author)Background: Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. Aim of the study: To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel trial. Methods: Three...article 2003
- document
-
Kruisdijk, F. (author), Deenik, J. (author), Yenback, D. (author), Tak, E.C. (author), van Harten, P. (author), Hopman-Rock, M. (author), Hendriksen, I. (author)Sedentary behaviour and lack of physical activity threatens health. Research concerning these behaviours of inpatients with severe mental illness is limited but urgently needed to reveal prevalence and magnitude. In total, 184 inpatients (men n =108, women n =76, mean age 57,4, 20% first generation antipsychotics, 40% second generation...article 2017
- document
-
Wasser, M.N.J.M. (author), Koppert, P.W. (author), Arndt, J.W. (author), Emeis, J.J. (author), Feitsma, R.I.J. (author), Pauwels, E.K.J. (author), Nieuwenhuizen, W. (author), Gaubius Instituut TNO (author)Balb/c mice were immunized with human plasmin-generated fibrinogen degradation product Y. Spleen cells were fused with P3X63-Ag8.653 myeloma cells. A clone (Y22) was found that produces monoclonal antibodies (MoAbs) with a strong reactivity with human fibrin and only a weak reactivity with fibrinogen in an enzyme immunoassay (EIA). Y22 also...article 1989
- document
-
van Hinsbergh, V.W.M. (author), Kooistra, T. (author), van den Berg, E.A. (author), Princen, H.M.G. (author), Fiers, W. (author), Emeis, J.J. (author), Gaubius instituut TNO (author)The vascular endothelium plays an important role in fibrinolysis by producing tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI). The monokine tumor necrosis factor (human recombinant TNF) increased the production of PAI by cultured human endothelial cells from umbilical vein (twofold) and from foreskin...article 1988
- document
-
van de Water, H.P.A. (author), Bijleveld, C.C.J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)Eind 1990 verschenen in dit tijdschrift twee artikelen over het aantal met HIV geïnfecteerden in Nederland. Hieruit bleek dat het aantal HIV-seropositieven lager lag dan eerder werd aangenomen, maar dat desondanks een stijgend aantal AIDS-patiënten verwacht mocht worden. In uitkomsten liepen de twee onderzoeken niet ver uiteen. Jager et al....article 1992
- document
-
Haas, F.J.L.M. (author), Kluft, C. (author), Biesma, D.H. (author), Schutgens, R.E.G. (author)The objective of the present study was to evaluate the influence of thrombophilia risk factors on variables of a chromogenic thrombin generation assay (ETP) in a setting with acute deep venous thrombosis (DVT) and non-DVT patients. In 152 outpatients suspected for DVT, the results of thrombophilia investigations were known. In all patients,...article 2011
(81 - 100 of 437)