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Dhondt, S. (author), Oeij, P.R.A. (author), Schröder, A. (author)
Human and financial resources as well as organisational capabilities are needed to overcome the manifold constraints social innovators are facing. To unlock the potential of social innovation for the whole society new (social) innovation friendly environments and new governance structures (ecosystems) have to be set-up to foster social...
bookPart 2018
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Siemonsma, P.C. (author), Blom, J.W. (author), Hofstetter, H. (author), van Hespen, A.T.H. (author), Gussekloo, J. (author), Drewes, Y.M. (author), van Meeteren, N.L.U. (author)
Background: A physically active lifestyle in older people contributes to the preservation of good health. We assessed the influence of physiotherapy on daily functioning among community dwelling older people (75+) with complex health problems identified with screening, versus usual care. We also compared functional task exercise (FTE), with...
article 2018
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Reijnen, A. (author), Geuze, E. (author), Eekhout, I. (author), Maihofer, A.X. (author), Nievergelt, C.M. (author), Baker, D.G. (author), Vermetten, E. (author)
In order to decrease the risk of developing stress-related disorders after military deployment, biological vulnerability factors should be identified. Neuropeptide Y (NPY) is a peptide neurotransmitter that is associated with modulation of the stress response. Using the data of two longitudinal prospective cohort studies (N = 892 and N = 2427),...
article 2018
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Zwaveling-Soonawala, N. (author), Trotsenburg, A.S. (author), Verkerk, P.H. (author)
Context. In central hypothyroidism (CeH) free thyroxine (FT4) concentrations are low while TSH concentrations may be low, normal or even slightly elevated due to reduced bioactivity. Congenital CeH (CCeH) may be isolated or part of multiple pituitary hormone deficiency (MPHD). Objective. To test our hypotheses that (1) TSH concentrations have a...
article 2018
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Spriensma, A.S. (author), Eekhout, I. (author), de Boer, M.R. (author), Luime, J.J. (author), de Jong, P.H. (author), Bahçecitapar, M.K. (author), Heymans, M.W. (author), Twisk, J.W.R. (author)
Background: Randomised controlled trials (RCTs) are the gold standard to estimate treatment effects. When patients receive effective treatment over time they may reach the limit of a certain measurement scale. This phenomenon is known as censoring and leads to skewed distributions of the outcome variable with an excess of either low (floor...
article 2018
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Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)
Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...
article 2018
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Bouwhuis, S. (author), de Wind, A. (author), de Kruif, A. (author), van der Beek, A.J. (author), Bongers, P.M. (author), Boot, C.R.L. (author)
Background. Multiple job holding (MJH) is a common and growing phenomenon in many countries. Little is known about experiences with MJH among older workers. The objective of the present study is to gain insight in experiences with MJH among Dutch workers aged 45 years and older. Methods. Multiple job holders were selected from the Study on...
article 2018
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Niks, I.M.W. (author), Gevers, J.M.P. (author), de Jonge, J. (author), Houtman, I.L.D. (author)
Effective interventions to prevent work stress and to improve health, well-being, and performance of employees are of the utmost importance. This quasi-experimental intervention study presents a specific method for diagnosis of psychosocial risk factors at work and subsequent development and implementation of tailored work stress interventions,...
article 2018
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van Groen, B.D. (author), van de Steeg, E. (author), Mooij, M.G. (author), van Lipzig, M.M.H. (author), de Koning, B.A.E. (author), Verdijk, R.M. (author), Wortelboer, H.M. (author), Gaedigk, R. (author), Bi, C. (author), Leeder, S. (author), van Schaik, R.H.N. (author), van Rosmalen, J. (author), Tibboel, D. (author), Vaes, W.H. (author), de Wildt, S.N. (author)
Background Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples. Methods Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3,...
article 2018
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de Vet, H.C.W. (author), Mullender, M.G. (author), Eekhout, I. (author)
Objective: The concept of specific agreement (SA) has been proposed for dichotomous outcomes for two or more raters. We aim to extend this concept for variables with more than two ordinal or nominal categories and more than two raters. Study Design and Setting: We used two data sets: four plastic surgeons classifying photographs after breast...
article 2018
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van der Kleij, R. (author), Hueting, T.F. (author), Schraagen, J.M.C. (author)
Dynamic Positioning (DP) is a computer-controlled process to automatically keep a floating vessel at a specific position or to follow a pre-defined path (tracking) by using its own propellers and thrusters. The human supervisory controller has no direct need to constantly know what the status is of all parts of the automation and the system it...
article 2018
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Smith, L.K. (author), Hindori-Mohangoo, A.D. (author), Delnord, M. (author), Durox, M. (author), Szamotulska, K. (author), Macfarlane, A. (author), Barros, H. (author), Gissler, M. (author), Blondel, B. (author), Zeitlin, J. (author)
Background. International comparisons of stillbirth allow assessment of variations in clinical practice to reduce mortality. Currently, such comparisons include only stillbirths from 28 or more completed weeks of gestational age, which underestimates the true burden of stillbirth. With increased registration of early stillbirths in high-income...
article 2018
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Mevissen, F.E.F. (author), van Empelen, P. (author), Watzeels, A. (author), van Duin, G. (author), Meijer, S. (author), van Lieshout, S. (author), Kok, G. (author)
This paper describes the development of a Dutch online programme called Long Live Love+ focusing on positive, coercion-free relationships, contraception use, and the prevention of STIs, using the Intervention Mapping (IM) approach. All six steps of the approach were followed. Step 1 confirmed the need for a sexual health programme targeting...
article 2018
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Tielman, M.L. (author), Neerincx, M.A. (author), van Meggelen, M. (author), Franken, I. (author), Brinkman, W.P. (author)
BACKGROUND AND OBJECTIVE: With the rise of autonomous e-mental health applications, virtual agents can play a major role in improving trustworthiness, therapy outcome and adherence. In these applications, it is important that patients adhere in the sense that they perform the tasks, but also that they adhere to the specific recommendations on...
article 2017
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Liang, L. (author), Bernhardsson, S. (author), Vernooij, R.W.M. (author), Armstrong, M.J. (author), Bussières, A. (author), Brouwers, M.C. (author), Gagliardi, A.R. (author), Alhabib, S. (author), Fleuren, M. (author), Fortino, M. (author), Mazza, D. (author), O'Rourke, N. (author), Willson, M. (author)
Background: Guidelines support health care decision-making and high quality care and outcomes. However, their implementation is sub-optimal. Theory-informed, tailored implementation is associated with guideline use. Few guideline implementation studies published up to 1998 employed theory. This study aimed to describe if and how theory is now...
article 2017
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San-Cristobal, R. (author), Navas-Carretero, S. (author), Livingstone, K.M. (author), Celis-Morales, C. (author), Macready, A.L. (author), Fallaize, R. (author), O’Donovan, C.B. (author), Lambrinou, C.P. (author), Moschonis, G. (author), Marsaux, C.F.M. (author), Manios, Y. (author), Jarosz, M. (author), Daniel, H. (author), Gibney, E.R. (author), Brennan, L. (author), Drevon, C.A. (author), Gundersen, T.E. (author), Gibney, M. (author), Saris, W.H.M. (author), Lovegrove, J.A. (author), Grimaldi, K. (author), Parnell, L.D. (author), Bouwman, J. (author), Ommen, B. (author), Mathers, J.C. (author), Alfredo Martinez, J. (author)
Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background...
article 2017
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Leist, M. (author), Ghallab, A. (author), Graepel, R. (author), Marchan, R. (author), Hassan, R. (author), Bennekou, S.H. (author), Limonciel, A. (author), Vinken, M. (author), Schildknecht, S. (author), Waldmann, T. (author), Danen, E. (author), van Ravenzwaay, B. (author), Kamp, H. (author), Gardner, I. (author), Godoy, P. (author), Bois, F.Y. (author), Braeuning, A. (author), Reif, R. (author), Oesch, F. (author), Drasdo, D. (author), Höhme, S. (author), Schwarz, M. (author), Hartung, T. (author), Braunbeck, T. (author), Beltman, J. (author), Vrieling, H. (author), Sanz, F. (author), Forsby, A. (author), Gadaleta, D. (author), Fisher, C. (author), Kelm, J. (author), Fluri, D. (author), Ecker, G. (author), Zdrazil, B. (author), Terron, A. (author), Jennings, P. (author), van der Burg, B. (author), Dooley, S. (author), Meijer, A.H. (author), Willighagen, E. (author), Martens, M. (author), Evelo, C. (author), Mombelli, E. (author), Taboureau, O. (author), Mantovani, A. (author), Hardy, B. (author), Koch, B. (author), Escher, S. (author), van Thriel, C. (author), Cadenas, C. (author), Kroese, D. (author), van de Water, B. (author), Hengstler, J.G. (author)
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event...
article 2017
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Bezem, J. (author), Heinen, D. (author), Reis, R. (author), Buitendijk, S.E. (author), Numans, M.E. (author), Kocken, P.L. (author)
Background The organisation of health assessments by preventive health services focusing on children’s health and educational performance needs to be improved due to evolving health priorities such as mental health problems, reduced budgets and shortages of physicians and nurses. We studied the impact on the school professionals’ perception of...
article 2017
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Sewdas, R. (author), de Wind, A. (author), van der Zwaan, L.G.L. (author), van der Borg, W.E. (author), Steenbeek, R. (author), van der Beek, A.J. (author), Boot, C.R.L. (author)
article 2017
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Schelvis, R.M.C. (author), Wiezer, N.M. (author), van der Beek, A.J. (author), Twisk, J.W.R. (author), Bohlmeijer, E.T. (author), Oude Hengel, K.M. (author)
Background. Work-related stress is highly prevalent in the educational sector. The aim of the current study was to evaluate the effectiveness of an organizational level, participatory intervention on need for recovery and vitality in educational workers. It was hypothesized that the intervention would decrease need for recovery and increase...
article 2017
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