(81 - 100 of 2,231)
- document
-
van Loon, K. (author), Breteler, M.J.M. (author), van Wolfwinkel, L. (author), Rheineck Leyssius, A.T. (author), Kossen, A.S. (author), Kalkman, C.J. (author), van Zaane, B. (author), Peelen, L.M. (author)Altered respiratory rate is one of the first symptoms of medical conditions that require timely intervention, e.g., sepsis or opioid-induced respiratory depression. To facilitate continuous respiratory rate monitoring on general hospital wards a contactless, non-invasive, prototype monitor was developed using frequency modulated continuous wave...article 2016
- document
-
Kong, G. (author), Alais, D. (author), van der Burg, E.D. (author)In the present study, we examine how observers search among complex displays. Participants were asked to search for a big red horizontal line among 119 distractor lines of various sizes, orientations and colours, leading to 36 different feature combinations. To understand how people search in such a heterogeneous display, we evolved the search...article 2016
- document
-
Bernaards, C. (author), Hildebrandt, V.H. (author), Hendriksen, I.J. (author)Background. Evidence shows that prolonged sitting is associated with an increased risk of mortality, independent of physical activity (PA). The aim of the study was to identify correlates of sedentary time (ST) in different age groups and day types (i.e. school-/work day versus non-school-/non-work day). Methods. The study sample consisted of...article 2016
- document
-
Schelvis, R.M.C. (author), Wiezer, N.M. (author), Blatter, B.M. (author), van Genabeek, J.A.G.M. (author), Oude Hengel, K.M. (author), Bohlneijer, E.T. (author), van der Beek, A.J. (author)Background The importance of process evaluations in examining how and why interventions are (un) successful is increasingly recognized. Process evaluations mainly studied the implementation process and the quality of the implementation (fidelity). However, in adopting this approach for participatory organizational level occupational health...article 2016
- document
-
Wierenga, D. (author), Engbers, L.H. (author), van Empelen, P. (author), van Mechelen, W. (author)Objective: The aim of this study was to evaluate the use of and adherence to a 7-step strategy for the development, implementation, and continuation of a comprehensive, multicomponent lifestyle program. Methods: Strategy use and adherence was assessed with 12 performance indicators. Data were collected by combining onsite monitoring with semi...article 2016
- document
-
Schrieks, I.C. (author), Heil, A.L. (author), Hendriks, H.F. (author), Mukamal, K.J. (author), Beulens, J.W. (author)OBJECTIVE: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. This reduced risk might be explained by improved insulin sensitivity or improved glycemic status, but results of intervention studies on this relation are inconsistent. The purpose of this study was to conduct a systematic review and meta-analysis of...article 2015
- document
-
Koster, S. (author), Leeman, W.R. (author), Verheij, E.R. (author), Dutman, A.E. (author), van Stee, L.L.P. (author), Munch Nielsen, L. (author), Ronsmans, S. (author), Noteborn, H. (author), Krul, L. (author)A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...article 2015
- document
-
Vlaming, M.L. (author), van Duijn, E. (author), Dillingh, M.R. (author), Brands, R. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Bosgra, S. (author), Burggraaf, J. (author), de Koning, M.C. (author), Fidder, A. (author), Mocking, J.A. (author), Sandman, H. (author), de Ligt, R.A. (author), Fabriek, B.O. (author), Pasman, W.J. (author), Seinen, W. (author), Alves, T. (author), Carrondo, M. (author), Peixoto, C. (author), Peeters, P.A. (author), Vaes, W.H. (author)Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show for the first time that pharmacokinetic data of NBEs in humans can be successfully obtained early...article 2015
- document
-
van Buuren, S. (author), Bezemer, R.A. (author), Reijneveld, S.A. (author), L' Hoir, M.P. (author)Curve matching is a new big data technique to predict an outcome given earlier measurements. Here we apply curve matching to predict the future growth of a specific child, the target child. The method searches in large datasets of longitudinal growth data for other children who are similar to the target child in terms of factors that influence...article 2015
- document
-
Reinen, J. (author), Nematollahi, L. (author), Fidder, A. (author), Vermeulen, N.P.E. (author), Noort, D. (author), Commandeur, J.N.M. (author)Tri-ortho-cresyl phosphate (ToCP) is a multipurpose organophosphorus compound that is neurotoxic and suspected to be involved in aerotoxic syndrome in humans. It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may be responsible for this effect as it can...article 2015
- document
-
Turner, M.A. (author), Mooij, M.G. (author), Vaes, W.H.J. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Knibbe, C.A.J. (author), Körgvee, L.T. (author), Maruszak, W. (author), Grynkiewicz, G. (author), Garner, R.C. (author), Tibbocl, D. (author), Park, B.K. (author), de Wildt, S.N. (author)Important information gaps remain on the efficacy and safety of drugs in children. Pediatric drug development encounters several ethical, practical, and scientifîc chaflenges One barrier to the evaluation of medicines for children is a lack of Innovative methodologies that have been adapted to the needs of chiIdren This article presents our...article 2015
- document
-
Zwaveling-Soonawala, N. (author), Trotsenburg, A.S. (author), Verkerk, P.H. (author)Congenital hypothyroidism (CH) may be of thyroidal (CHT) or central origin (CHC). Worldwide, most neonatal screening programs are TSH based and effectively detect CHT. Only a few screening programs measure total or free T4 and TSH simultaneously or stepwise, enabling detection of CHT as well as CHC. A frequently used argument against screening...article 2015
- document
-
Morales-Hurtado, M. (author), Zeng, X. (author), Gonzalez-Rodriguez, P. (author), ten Elshof, J.E. (author), van der Heide, E. (author)Research on human skin interactions with healthcare and lifestyle products is a topic continuously attracting scientific studies over the past years. It is possible to evaluate skin mechanical properties based on human or animal experimentation, yet in addition to possible ethical issues, these samples are hard to obtain, expensive and give rise...article 2015
- document
-
de Wind, A. (author), Geuskens, G.A. (author), Ybema, J.F. (author), Bongers, P.M. (author), van der Beek, A.J. (author)Objectives Determinants in the domains health, job characteristics, skills, and social and financial factors may influence early retirement through three central explanatory variables, namely, the ability, motivation, and opportunity to work. Based on the literature, we created the Early Retirement Model. This study aims to investigate whether...article 2015
- document
-
Wagner, A. (author), Cohen, N. (author), Kelder, T. (author), Amit, U. (author), Liebman, E. (author), Steinberg, D.M. (author), Radonjic, M. (author), Ruppin, E. (author)High-throughput omics have proven invaluable in studying human disease, and yet day-to-day clinical practice still relies on physiological, non-omic markers. The metabolic syndrome, for example, is diagnosed and monitored by blood and urine indices such as blood cholesterol levels. Nevertheless, the association between the molecular and the...article 2015
- document
-
Kamphuis, M. (author), van de Nieuwegiessen, A.I. (author), Span, P.M. (author)Background Dutch Youth health care is an easily accessible service where parents can ask for support for the healthy development of their children. The majority of the screenings and medical examinations show no abnormalities. Sometimes there is doubt about the severity of symptoms: the line between healthy variation and diseases or...article 2014
- document
-
van der Pal-de Bruin, K.M. (author), Heerdink, N. (author), Kamphuis, M. (author), Pols, M.A. (author)Conflict of interest and financial support: disclosure forms provided by the authors are available along with the full text of this article at www.ntvg.nl, search for A6745; click on ‘Belangenverstrengeling’ (‘Conflict of interest’). The Netherlands Organization for Health Research and Development provided a subsidy (subsidy no 156000009) to the...article 2014
- document
-
Bakker, M. (author), van der Beek, A.J. (author), Hendriksen, I.J.M. (author), Bruinvels, D.J. (author), van Poppel, M.N. (author)Objectives The aim of this study was to investigate which prepartum determinants contribute to the development of postpartum (PP) fatigue among working women in the Netherlands. Methods A prospective cohort study in 15 Dutch companies was conducted to measure different potential predictors using self-administrated questionnaires at baseline and...article 2014
- document
-
de Kock, K.A. (author), Steenbeek, R. (author), Buijs, P.C. (author), Lucassen, P.L. (author), Knottnerus, J.A. (author), Lagro-Janssen, A.L. (author)Background. Work and being able to work are important prerequisites for health and well being. Health problems can have a negative influence on the ability to work and not being able to work can be detrimental for patients’ psychosocial well being. Although GPs are aware of this importance they do not always structurally pay attention to...article 2014
- document
-
Lakerveld, J. (author), van der Ploeg, H.P. (author), Kroezel, W. (author), Ahrens, W. (author), Allais, O. (author), Frost Andersen, L. (author), Cardons, G. (author), Capranica, L. (author), Chastin, S. (author), Donnelly, A. (author), Ekelund, U. (author), Finglash, P. (author), Flechtner-Mors, M. (author), Hebestrei, A. (author), Hendriksen, I. (author), Kubiak, T. (author), Lanza, M. (author), Loyen, A. (author), MacDonncha, C. (author), Mazzocch, M. (author), Monsivais, P. (author), Murphy, M. (author), Nöthlings, U. (author), O’Gorman, D.J. (author), Renner, B. (author), Roos, G. (author), Schuit, A.J. (author), Schulze, M. (author), Steinacker, J. (author), Stronks, K. (author), Volkert, D. (author), van 't Veer, P. (author), Lien, N. (author), de Bourdeaudhuij, I. (author), Brug, J. (author)To address major societal challenges and enhance cooperation in research across Europe, the European Commission has initiated and facilitated ‘joint programming’. Joint programming is a process by which Member States engage in defining, developing and implementing a common strategic research agenda, based on a shared vision of how to address...article 2014
(81 - 100 of 2,231)