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Boesveld, I.C. (author), Hermus, M.A.A. (author), van der Velden-Bollemaat, E.C. (author), Hitzert, M. (author), de Graaf, H.J. (author), Franx, A. (author), Wiegers, T.A. (author)
Objective: to determine the usability of a recently developed set of 30 structure and process birth centre quality indicators. Design: an explorative study using mixed-methods including literature, a survey, interviews and observations. The study is part of the Dutch Birth Centre Study. We first determined the measurability of birth centre...
article 2018
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Viester, L. (author), Verhagen, E.A.L.M. (author), Bongers, P.M. (author), van der Beek, A.J. (author)
Purpose: To evaluate the effectiveness of an individually tailored intervention for improvement in lifestyle behavior, health indicators, and prevention and reduction of overweight among construction workers. Design: Randomized controlled trial. Setting: Various blue-collar departments of a large construction company in the Netherlands....
article 2018
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Klein Velderman, M. (author), Pannebakker, F.D. (author), van Vliet, W. (author), Reijneveld, S.A. (author)
Objective: Parental divorce has strong impacts on children. Evidence-based programs to support young children after parental divorce are rare. The U.S.-developed Children of Divorce Intervention Program (CODIP) is one of these. CODIP’s effectiveness outside the U.S. setting is to be further replicated. This study aimed at cultural adaptation of...
article 2018
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de Groot, J.F. (author), Damen, N. (author), de Loos, E. (author), Goorhuis, J. (author), Wagner, C. (author)
Background: Paediatric Early Warning Scores (PEWS) are increasingly being used for early identification and management of clinical deterioration in paediatric patients. A PEWS system includes scores, cut-off points and appropriate early intervention. In 2011, The Dutch Ministry of Health advised hospitals to implement a PEWS system in order to...
article 2018
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Wijn, R. (author)
article 2018
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Huysamen, K. (author), Bosch, T. (author), de Looze, M. (author), Stadler, K.S. (author), Graf, E. (author), O'Sullivan, L.W. (author)
The aim of this study was to evaluate the effect of a passive upper body exoskeleton on muscle activity, perceived musculoskeletal effort, local perceived pressure and subjective usability for a static overhead task. Eight participants (4 male, 4 female) held a load (0 kg and 2 kg) three times overhead for a duration of 30 s each, both with and...
article 2018
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Morrison, M.C. (author), Kleemann, R. (author), van Koppen, A. (author), Hanemaaijer, R. (author), Verschuren, L. (author)
Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined in human studies. Investigation of key pathogenic mechanisms requires the use of pre-clinical...
article 2018
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Fonseca, A.S. (author), Kuijpers, E. (author), Kling, K.I. (author), Levin, M. (author), Koivisto, A.J. (author), Nielsen, S.H. (author), Fransman, W. (author), Fedutik, Y. (author), Jensen, K.A. (author), Koponen, I.K. (author)
Fume hoods are one of the most common types of equipment applied to reduce the potential of particle exposure in laboratory environments. A number of previous studies have shown particle release during work with nanomaterials under fume hoods. Here, we assessed laboratory workers’ inhalation exposure during synthesis and handling of CuO, TiO2...
article 2018
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Notenboom, S. (author), Weigand, K.M. (author), Proost, J.H. (author), van Lipzig, M.M.H. (author), van de Steeg, E. (author), van den Broek, P.H.H. (author), Greupink, R. (author), Russel, F.G.M. (author), Groothuis, G.M.M. (author)
Drug-induced liver injury (DILI) is a common reason for drug withdrawal from the market. An important cause of DILI is drug-induced cholestasis. One of the major players involved in drug-induced cholestasis is the bile salt efflux pump (BSEP; ABCB11). Inhibition of BSEP by drugs potentially leads to cholestasis due to increased (toxic)...
article 2018
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Huysamen, K. (author), de Looze, M.P. (author), Bosch, T. (author), Ortiz, J. (author), Toxin, S. (author), O'Sullivan, L.W. (author)
The aim of this study was to evaluate the effect of an industrial exoskeleton on muscle activity, perceived musculoskeletal effort, measured and perceived contact pressure at the trunk, thighs and shoulders, and subjective usability for simple sagittal plane lifting and lowering conditions. Twelve male participants lifted and lowered a box of 7...
article 2018
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Remington, B. (author), Broekman, H.C.H. (author), Blom, W.M. (author), Capt, A. (author), Crevel, R.W.R. (author), Dimitrov, I. (author), Faeste, C.K. (author), Fernandez-Canton, R. (author), Giavi, S. (author), Houben, G.F. (author), Glenn, K.C. (author), Madsen, C.B. (author), Kruizinga, A.K. (author), Constable, A. (author)
The development and introduction of new dietary protein sources has the potential to improve food supply sustainability. Understanding the potential allergenicity of these new or modified proteins is crucial to ensure protection of public health. Exposure to new proteins may result in de novo sensitization, with or without clinical allergy, or...
article 2018
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Reisinger, K. (author), Blatz, V. (author), Brinkmann, J. (author), Downs, T.R. (author), Fischer, A. (author), Henkler, F. (author), Hoffmann, S. (author), Krul, C. (author), Liebsch, M. (author), Luch, A. (author), Pirow, R. (author), Reus, A.A. (author), Schulz, M. (author), Pfuhler, S. (author)
Recently revised OECD Testing Guidelines highlight the importance of considering the first site-of-contact when investigating the genotoxic hazard. Thus far, only in vivo approaches are available to address the dermal route of exposure. The 3D Skin Comet and Reconstructed Skin Micronucleus (RSMN) assays intend to close this gap in the in vitro...
article 2018
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Kuper, C.F. (author), van Bilsen, J. (author), Wijnands, M.V.W. (author)
The thoracic cavities receive increasing attention in toxicology, because inhaled fibers and (nano)particles can reach these cavities and challenge the local lymphoid tissues. The thoracic and abdominopelvic cavities are controlled by the serosal immune system with its special, loosely organized lymphoid clusters, namely the fat-associated...
article 2018
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Koopmans, L. (author), Damen, N. (author), Wagner, C. (author)
Objectives Many European countries face challenges in long-term care for older people, such as the growing number of older people requiring care, the increasing complexity of their health care problems, and a decreasing workforce that is inadequately prepared. Optimizing the staff and skill mix of health care teams may offer part of the solution...
article 2018
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Ding, D. (author), Neerincx, M.A. (author), Brinkman, W.P. (author)
Introduction: Inner voice is estimated to occur at least a quarter of people’s conscious waking life. Much research work asserts that inner voice plays various important roles in cognitive functions, such as self-regulation, self-reflection, and so on. Virtual cognitions are a stream of simulated thoughts people can hear while emerged in a...
article 2018
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Fallaize, R. (author), Livingstone, K.M. (author), Celis-Morales, C. (author), Macready, A.L. (author), San-Cristobal, R. (author), Navas-Carretero, S. (author), Marsaux, C.F.M. (author), O’Donovan, C.B. (author), Kolossa, S. (author), Moschonis, G. (author), Walsh, M.C. (author), Gibney, E.R. (author), Brennan, L. (author), Bouwman, J. (author), Manios, Y. (author), Jarosz, M. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gundersen, T.E. (author), Drevon, C.A. (author), Gibney, M.J. (author), Mathers, J.C. (author), Lovegrove, J.A. (author)
Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore,...
article 2018
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Veeningen, M. (author), Chatterjea, S. (author), Horváth, A.Z. (author), Spindler, G. (author), Boersma, E. (author), van der Spek, P. (author), van der GaliËn, O. (author), Gutteling, J. (author), Kraaij, W. (author), Veugen, P.J.M. (author)
conference paper 2018
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Blanson Henkemans, O.A. (author), Keij, M. (author), Grootjen, M. (author), Kamphuis, M. (author), Dijkshoorn, A. (author)
Background: The StartingTogether program (in Dutch SamenStarten) is a family-centred method for early identification of social-emotional and behavioural problems in young children. Nurses in preventive child health care find it challenging to: determine family issues and need for care; provide education; refer to social services; increase parent...
article 2018
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Oeij, P.R.A. (author), Dhondt, S. (author), Ooms, M. (author)
The Netherlands is catching up with social innovation. In the former century combating social problems was a task of public organisations and government, largely carried out top down. Today the responsibility to tackle social issues is partly shifting to public-private partnerships, social enterprises and communities.
bookPart 2018
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Steckling, N. (author), Gotti, A. (author), Bose-O'Reilly, S. (author), Chapizanis, D. (author), Costopoulou, D. (author), de Vocht, F. (author), Garí, M. (author), Grimalt, J.O. (author), Heath, E. (author), Hiscock, R. (author), Jagodic, M. (author), Karakitsios, S.P. (author), Kedikoglou, K. (author), Kosjek, T. (author), Leondiadis, L. (author), Maggos, T. (author), Mazej, D. (author), Polańska, K. (author), Povey, A. (author), Rovira, J. (author), Schoierer, J. (author), Schuhmacher, M. (author), Špirić, Z. (author), Stajnko, A. (author), Stierum, R. (author), Tratnik, J.S. (author), Vassiliadou, I. (author), Annesi-Maesano, I. (author), Horvat, M. (author), Sarigiannis, D.A. (author)
Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all...
article 2018
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