Grafting of venous leg ulcers. An intraindividual comparison between cultured skin equivalents and full-thickness skin punch grafts

Skin equivalents that consisted of a noncontracted collagen gel populated with allogeneic fibroblasts and covered with autologous cultured keratinocytes were used for grafting venous leg ulcers. The results were compared in the same patient with those obtained with a routinely used standard method of grafting with autologous full-thickness punch...

Aids-related knowledge, attitudes, and behavior: A comparison of dutch students and dropouts

School dropouts are considered an important target group for AIDS prevention. They are expected to be less knowledgeable about AIDS and to show a higher degree of risky behavior as compared with their school-attending peers. Several small-scale studies among specific groups of dropouts seem to confirm such expectations. However, due to...

Re-evaluation of the haptoglobin reference values with the radial immunodiffusion technique

The reference values of the three main types of serum haptoglobin Hp 1-1, Hp 2-1, and Hp 2-2, as determined by radial immunodiffusion and with phenotype determination on polyacrylamide gel electrophoresis have been re-evaluated for both sexes. For that purpose about 500 serum samples were collected from normal, healthy Dutch volunteers. The...

Effect of work load on free and sulfate-conjugated plasma catecholamines, prolactin, and cortisol

The effects of maximal performance capacity and different work load intensities on the response of free and sulfate-conjugated plasma catecholamines, prolactin (PRL), and cortisol were studied in six healthy male volunteers. In a first experiment, the volunteers had to perform a step-wise incremental bicycle ergometer test to determine the onset...

Validation and sensitivity analysis of probabilistic models of dietary exposure to micronutrients: An example based on vitamin B6

Probabilistic modelling can be used to get an insight into the variability and uncertainty of the nutrient intake in a population. When a probabilistic model is used, it is important that it is validated. Furthermore, a sensitivity analysis of the model output can give an insight into the most important input variables of the model and can be...

Degenerated and healthy cartilage are equally vulnerable to blood-induced damage

Background: Joint bleeds have a direct adverse effect on joint cartilage, leading to joint deterioration and, ultimately, to disability. Objective: To examine the hypothesis that because degenerated cartilage has a limited repair capacity, it is more susceptible than healthy cartilage to blood-induced cartilage damage. Methods: Healthy,...

Zygosity diagnosis in young twins by parental report

This study reports on zygosity determination in twins of childhood age. Parents responded to questionnaire items dealing with twin similarity in physical characteristics anti frequency of mistaking one twin for another by parents, relatives and strangers. The accuracy of zygosity diagnosis was evaluated across twins aged 6, 8, and 10 and across...

Employment perspectives of patients with ankylosing spondylitis

Objectives: To assess the labour market position of patients with ankylosing spondylitis (AS) in relation to disease duration and to identify potential factors in relation to withdrawal from the labour force. Methods: A cross sectional mail survey was conducted among 658 patients with AS. Participation in the labour force was defined as having a...

Vehicle control during curve driving

Based on a preview-predictor model, the time-to-line crossing (TLC) description was developed to quantify the potential role of error-neglecting strategies in driving. In a previous study the usefulness of the TLC concept was illustrated for straight lane keeping. In the present analysis TLC was applied to describe steering through a curve. When...

Maximum oxygen uptake in healthy nonathletic males

Maximum oxygen uptake ( {Mathematical expression} max), maximum heart rate (MHR), blood lactic acid (LA) and pH were measured during bicycle ergometer exercise in 52 men, 22 to 60 years old, engaged in clerical and light manual work (prison personnel and prisoners in the Netherlands). {Mathematical expression} max decreases with, age, but less...

REACH Worker Exposure Assessments: Ensuring Meaningful Health Risk Communication

Objectives: Within the chemical legislation, REACH was implemented in order to improve safe working conditions with hazardous substances. Literature and real-life experiences by those concerned have shown that there are still gaps with a need for improved risk communication. This study elaborated on how information provided by REACH is...

Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia

In a group of 120 patients with heterozygous familial hypercholesterolemia (FH) the influence of the apolipoprotein E (apoE) polymorphism on pre-treatment plasma lipid levels and on the response to treatment with simvastatin was studied. The apoE phenotype distribution did not differ significantly between the FH group and a sample group of the...

Thrombus detection using a Tc-99m labelled antifibrin monoclonal antibody (MoAb) experiments in vitro and in animals

This paper describes the production and characterization of an antifibrin monoclonal antibody, produced by immunizing mice with fibrinogen degradation fragment by the antibody (designated Y22) is directed against a conformation dependent epitope in the D-domain of fibrin Y22 was labeled with the radionuclide Tc-99m. Experiments in vitro and in...

Fluoride in drinking water and caries progression in a Tanzanian child population

Predictors of mean phenylalanine levels during the first five years of life in patients with phenylketonuria who were treated early. Dutch National PKU Steering Committee.

We studied the relationship between plasma phenylalanine level at first diagnostic visit, country of origin of the mother, birth cohort, child clinic, sex, and social class on the one hand and mean plasma phenylalanine levels in the first five years of life on the other hand in patients with phenylketonuria (PKU) who were treated early. The...

Nutritional factors in lung, colon, and prostate carcinogenesis in animal models

Dietary factors are now considered to be among the most important environmental risk determinations for cancer. In addition to epidemiological studies, experimental animal studies are an important tool to investigate dietary modulation in carcinogenesis. Results of recent experimental studies on the effect of some nutrients indicate that vitamin...

Doppler haematotachographie: interpretatieproblemen env nieuwe mogelijkheden