(421 - 437 of 437)

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Medisch Biologisch Laboratorium TNO (author), Mol, M.A.E. (author), Nanninga, P.B. (author), van Eendenburg, J.P. (author), Westerhof, W. (author), Mekkes, J.R. (author), van Ginkel, C.J.W. (author)
Skin equivalents that consisted of a noncontracted collagen gel populated with allogeneic fibroblasts and covered with autologous cultured keratinocytes were used for grafting venous leg ulcers. The results were compared in the same patient with those obtained with a routinely used standard method of grafting with autologous full-thickness punch...
article 1991
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TNO Preventie en Gezondheid (author), Vogels, T. (author), Brugman, E. (author), van Zessen, G. (author)
School dropouts are considered an important target group for AIDS prevention. They are expected to be less knowledgeable about AIDS and to show a higher degree of risky behavior as compared with their school-attending peers. Several small-scale studies among specific groups of dropouts seem to confirm such expectations. However, due to...
article 1999
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Instituut CIVO-Toxicologie en Voeding TNO (author), Schrijver, J. (author), van Rijn, H.J.M. (author), Schreurs, W.H.P. (author)
The reference values of the three main types of serum haptoglobin Hp 1-1, Hp 2-1, and Hp 2-2, as determined by radial immunodiffusion and with phenotype determination on polyacrylamide gel electrophoresis have been re-evaluated for both sexes. For that purpose about 500 serum samples were collected from normal, healthy Dutch volunteers. The...
article 1984
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Instituut CIVO-Toxicologie en voeding TNO (author), Odink, J. (author), van der Beek, E.J. (author), van den Berg, H. (author), Bogaards, J.J.P. (author), Thissen, J.T.N.M. (author)
The effects of maximal performance capacity and different work load intensities on the response of free and sulfate-conjugated plasma catecholamines, prolactin (PRL), and cortisol were studied in six healthy male volunteers. In a first experiment, the volunteers had to perform a step-wise incremental bicycle ergometer test to determine the onset...
article 1986
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Rubingh, C.M. (author), Kruizinga, A.G. (author), Hulshof, K.F.A.M. (author), Brussaard, J.H. (author)
Probabilistic modelling can be used to get an insight into the variability and uncertainty of the nutrient intake in a population. When a probabilistic model is used, it is important that it is validated. Furthermore, a sensitivity analysis of the model output can give an insight into the most important input variables of the model and can be...
article 2003
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TNO Kwaliteit van Leven (author), Jansen, N.W.D. (author), Roosendaal, G. (author), Bijlsma, J.W.J. (author), de Groot, J. (author), Theobald, M. (author), Lafeber, F.P.J.G. (author)
Background: Joint bleeds have a direct adverse effect on joint cartilage, leading to joint deterioration and, ultimately, to disability. Objective: To examine the hypothesis that because degenerated cartilage has a limited repair capacity, it is more susceptible than healthy cartilage to blood-induced cartilage damage. Methods: Healthy,...
article 2008
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TNO Preventie en Gezondheid (author), Rietveld, M.J.H. (author), van der Valk, J.C. (author), Bongers, I.L. (author), Stroet, T.M. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
This study reports on zygosity determination in twins of childhood age. Parents responded to questionnaire items dealing with twin similarity in physical characteristics anti frequency of mistaking one twin for another by parents, relatives and strangers. The accuracy of zygosity diagnosis was evaluated across twins aged 6, 8, and 10 and across...
article 2000
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Chorus, A.M.J. (author), Boonen, A. (author), Miedema, H.S. (author), van der Linden, S. (author)
Objectives: To assess the labour market position of patients with ankylosing spondylitis (AS) in relation to disease duration and to identify potential factors in relation to withdrawal from the labour force. Methods: A cross sectional mail survey was conducted among 658 patients with AS. Participation in the labour force was defined as having a...
article 2002
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Instituut voor Zintuigfysiologie TNO (author), Godthelp, J. (author)
Based on a preview-predictor model, the time-to-line crossing (TLC) description was developed to quantify the potential role of error-neglecting strategies in driving. In a previous study the usefulness of the TLC concept was illustrated for straight lane keeping. In the present analysis TLC was applied to describe steering through a curve. When...
article 1986
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TNO Preventie en Gezondheid (author), Binkhorst, R.A. (author), Pool, J. (author), van Leeuwen, P. (author), Bouhuys, A. (author)
Maximum oxygen uptake ( {Mathematical expression} max), maximum heart rate (MHR), blood lactic acid (LA) and pH were measured during bicycle ergometer exercise in 52 men, 22 to 60 years old, engaged in clerical and light manual work (prison personnel and prisoners in the Netherlands). {Mathematical expression} max decreases with, age, but less...
article 1966
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Fransman, W. (author), Otten, W. (author), Marquart, H. (author), Preuhs, K. (author), Willemsen, J. (author), Boumann, H. (author), Gerritsen, R. (author)
Objectives: Within the chemical legislation, REACH was implemented in order to improve safe working conditions with hazardous substances. Literature and real-life experiences by those concerned have shown that there are still gaps with a need for improved risk communication. This study elaborated on how information provided by REACH is...
article 2023
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Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), de Knijff, P. (author), Stalenhoef, A.F.H. (author), Mol, M.J.T.M. (author), Gevers Leuven, J.A. (author), Smit, J. (author), Erkelens, D.W. (author), Schouten, J. (author), Frants, R.R. (author), Havekes, L.M. (author)
In a group of 120 patients with heterozygous familial hypercholesterolemia (FH) the influence of the apolipoprotein E (apoE) polymorphism on pre-treatment plasma lipid levels and on the response to treatment with simvastatin was studied. The apoE phenotype distribution did not differ significantly between the FH group and a sample group of the...
article 1990
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Gaubius Instituut TNO (author), Wasser, M.N.J.M. (author), Pauwels, E.K.J. (author), Nieuwenhuizen, W. (author)
This paper describes the production and characterization of an antifibrin monoclonal antibody, produced by immunizing mice with fibrinogen degradation fragment by the antibody (designated Y22) is directed against a conformation dependent epitope in the D-domain of fibrin Y22 was labeled with the radionuclide Tc-99m. Experiments in vitro and in...
article 1990
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Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author), Frencken, J.E. (author), Truin, G.J. (author), van't Hof, M.A. (author), K├Ânig, K.G. (author), Kahabuka, F.K. (author), Mulder, J. (author), Kalsbeek, H. (author)
article 1991
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TNO Preventie en Gezondheid (author), Verkerk, P.H. (author), van Spronsen, F.J. (author), van Houten, M. (author), Smit, G.P. (author), Sengers, R.C. (author)
We studied the relationship between plasma phenylalanine level at first diagnostic visit, country of origin of the mother, birth cohort, child clinic, sex, and social class on the one hand and mean plasma phenylalanine levels in the first five years of life on the other hand in patients with phenylketonuria (PKU) who were treated early. The...
article 1994
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Instituut CIVO-Toxicologie en voeding TNO (author), Kroes, R. (author), Beems, R.B. (author), Bosland, M.C. (author), Bunnik, G.S.J. (author), Sinkeldam, E.J. (author)
Dietary factors are now considered to be among the most important environmental risk determinations for cancer. In addition to epidemiological studies, experimental animal studies are an important tool to investigate dietary modulation in carcinogenesis. Results of recent experimental studies on the effect of some nutrients indicate that vitamin...
conference paper 1986
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Jonkman, E.J. (author), Mosmans, P.C.M. (author)
other 1977
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