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Wasser, M.N.J.M. (author), Koppert, P.W. (author), Arndt, J.W. (author), Emeis, J.J. (author), Feitsma, R.I.J. (author), Pauwels, E.K.J. (author), Nieuwenhuizen, W. (author), Gaubius Instituut TNO (author)Balb/c mice were immunized with human plasmin-generated fibrinogen degradation product Y. Spleen cells were fused with P3X63-Ag8.653 myeloma cells. A clone (Y22) was found that produces monoclonal antibodies (MoAbs) with a strong reactivity with human fibrin and only a weak reactivity with fibrinogen in an enzyme immunoassay (EIA). Y22 also...article 1989
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van Poppel, G. (author), Schrijver, J. (author), Meulmeester, J.F. (author), Kempen-Voogd, N. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: Cholesterol, 57-88-5; Iron, 7439-89-6; Vitaminsarticle 1989
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Engesser, L. (author), Brommer, E.J.P. (author), Kluft, C. (author), Briet, E. (author), Gaubius Instituut TNO (author)Two hundred and three patients with venous thrombophilia were investigated in order to find out whether an elevated plasma concentration of plasminogen activator inhibitor (PAI) could be a cause of their tendency to thrombosis. The patients were studied in an asymptomatic period about 3 months after their last thromboembolic episode. PAI...article 1989
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Kwekkeboom, J. (author), Princen, H.M.G. (author), van Voorthuizen, E.M. (author), Meijer, P. (author), Kempen, H.J.M. (author), Gaubius Instituut TNO (author)Intracellular accumulation of 37°C of 50 μM [14C]taurocholic acid by hepatocytes of pig and rat, cultured for 24 hours, and by human hepatocytes, cultured for 12 hours, reached equilibrium after an incubation time of 1 to 2 hours. Maximum capacity to accumulate taurocholate intracellularly was assessed in 3-hour incubations with increasing...article 1989
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Emeis, J.J. (author), van Houwelingen, A.C. (author), van den Hoogen, C.M. (author), Hornstra, G. (author), Gaubius Institute TNO, 2300 AP Leiden, Netherlands (author)For a period of 6 weeks, 76 healthy male volunteers consumed during their daily main meal the contents of one tin (~ 135 g) of either fish (mackerel) paste or meat paste. Fibrinolytic parameters were determined in plasma samples obtained at the beginning and at the end of the experimental period. No changes were found in plasminogen, α2...article 1989
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Centraal Instituut voor Voedingsonderzoek TNO (author), van Dokkum, W. (author), de Vos, R.H. (author), Muys Th., (author), Wesstra, J.A. (author)1. During a period of 2.5 years, every 3 months 221 different food items forming a 'market basket' were purchased, prepared and divided into twenty-three food-commodity groups. The 'market basket' was based on a study of the dietary intake of 18-year-old male, Dutch adolescents. In the (homogenized) food groups various minerals and trace...article 1989
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Bloem, M.W. (author), Wedel, M. (author), van Agtmaal, E.J. (author), Speek, A.J. (author), Saowakontha, S. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A group of 134 school children aged 3-9 y, with signs of conjunctival xerosis, from the rural area of Sakorn Nakhon province of Northeast Thailand were selected for a controlled study on the short-term effect (2 wk) of a single, oral high dose of vitamin A on iron metabolism. After collection of the baseline data, children within villages were...article 1990
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Lowik, M.R.H. (author), Schrijver, J. (author), Odink, J. (author), van den Berg, H. (author), Wedel, M. (author), Hermus, R.J.J. (author), TNO Kwaliteit van Leven (author)In a nationwide survey the nutritional status was assessed of 539 apparently healthy, independently living elderly aged 65-79 years. Anthropometric data showed no energy deficits. The prevalence of anemia was 4 and 1% among men and women, respectively. Many elderly showed a low level of 25-hydroxyvitamin D in plasma (< 31 nmol/L: men 35%; women...article 1990
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Holewijn, M. (author)In an experimental study of load carrying the effects of mass (0, 5.4, 10.4 kg) and the type of support (on the shoulder or on waist) on parameters of physiological strain were quantified to determine the factor(s) which limit carrying time. Four categories of strain were investigated: metabolic (in terms of oxygen uptake), cardiovascular (in...article 1990
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Kalsbeek, H. (author), Verrips, G.H. (author), TNO Preventie en Gezondheid (author)Data in a WHO report relating caries prevalence and the use of fluorides in different European countries were compared with data obtained directly from investigators in the field of oral epidemiology. The reliability of DMFT indices of 12-year-old children, mentioned in the WHO report, appeared sufficient to make comparisons between countries on...article 1990
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Fichtinger-Schepman, A.M.J. (author), Velde van der - Visser, S.D. (author), Dijk van - Knijnenburg, H.C.M. (author), van Oosterom, A.T. (author), Baan, R.A. (author), Berends, F. (author), TNO Voeding Medisch biologisch laboratorium TNO (author)During chemotherapy with a cisplatin-containing combination of drugs, 217 blood samples from 30 cancer patients were analyzed for the presence of the main cisplatin-DNA adduct cis-Pt(NH3)2d(pGpG) (Pt-GG). Cisplatin was administered during 3-h infusions on each of 5 consecutive days, resulting in increasing adduct levels which, on the average,...article 1990
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Meulmeester, J.F. (author), van der Berg, H. (author), Wedel, M. (author), Boshuis, P.G. (author), Hulshof, K.F.A. (author), Luyken, R. (author), TNO Preventie en Gezondheid Centraal Instituut voor Voedingsonderzoek TNO (author)At the end of the winter circulating concentrations of 25-hydroxyvitamin D (25-OHD) in Asian and Mediterranen immigrants in northwestern European countries are usually very low. This may lead to vitamin D deficiency and eventually to rickets. Children are more prone to develop vitamin D deficiency. The vitamin D status of 8-year-old Turkish,...article 1990
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Frencken, J.E. (author), Kalsbeek, H. (author), Verrips, G.H. (author), TNO Preventie en Gezondheid (author)In 1973, 1976, 1979, 1982 and 1988 caries investigations were carried out amongst 6- and 12-year-old primary schoolchildren to study the effectiveness of a dental health campaign begun in 1973. This campaign and the school dental health services were stopped in 1985. In all the years, except 1988, radiographs formed part of the caries...article 1990
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de Vos, R.H. (author), van Dokkum, W. (author), Schouten, A. (author), Jong de -Berkhout, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Over a period of 2.5 yr, 221 different food items of a 'market basket' of 18-yr-old males were purchased every 3 months. In total, 10 market baskets were collected. The foodstuffs were prepared by normal methods and combined into 23 commodity groups. Homogenates were prepared from each commodity group, followed by analysis for 17 different...article 1990
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Havenith, G. (author), van Middendorp, H. (author)An experiment was set up to quantify the relative influence of fitness, acclimatization, gender and anthropometric measures on physiological responses to heat stress. For this purpose, 12 male and 12 female subjects were exposed to a neutral [ambient temperature (T(a)) 21°C, relative humidity (r.h. 50%)], a warm, humid (T(a) 34°C, r.h. 80%) and...article 1990
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van Dokkum, W. (author), Schrijver, J. (author), Wesstra, J.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)The biological variability of the values of various biochemical indices used for the assessment of the nutritional status of man was investigated in 4 healthy male volunteers (mean age 23 years). They were given a constant diet for 60 d, with the nutrient intake at the level of the Dutch recommendations. Blood was collected twice a week and 24-h...article 1990
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Wertheim, A.H. (author), van Gelder, P. (author)When the eyes pursue a fixation point that sweeps across a moving background pattern, and the fixation point is suddenly made to stop, the ongoing motion of the background pattern seems to accelerate to a higher velocity. Experiment I showed that this acceleration illusion is not caused by the sudden change in (i) the relative velocity between...article 1990
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Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), de Knijff, P. (author), Stalenhoef, A.F.H. (author), Mol, M.J.T.M. (author), Gevers Leuven, J.A. (author), Smit, J. (author), Erkelens, D.W. (author), Schouten, J. (author), Frants, R.R. (author), Havekes, L.M. (author)In a group of 120 patients with heterozygous familial hypercholesterolemia (FH) the influence of the apolipoprotein E (apoE) polymorphism on pre-treatment plasma lipid levels and on the response to treatment with simvastatin was studied. The apoE phenotype distribution did not differ significantly between the FH group and a sample group of the...article 1990
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Gaubius Instituut TNO (author), Wasser, M.N.J.M. (author), Pauwels, E.K.J. (author), Nieuwenhuizen, W. (author)This paper describes the production and characterization of an antifibrin monoclonal antibody, produced by immunizing mice with fibrinogen degradation fragment by the antibody (designated Y22) is directed against a conformation dependent epitope in the D-domain of fibrin Y22 was labeled with the radionuclide Tc-99m. Experiments in vitro and in...article 1990
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Theeuwes, J. (author)Three visual search experiments tested whether top-down selectivity toward particular stimulus dimensions is possible during preattentive parallel search. Subjects viewed multielement displays in which two salient items, each unique in a different dimension—that is, color and intensity (Experiment 1) or color and form (Experiments 2 and 3)—were...article 1991
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