document

Design decisions for a real time, alcohol craving study using physio- and psychological measures

van Lier, H.G. (author), Oberhagemann, M. (author), Stroes, J.D. (author), Enewoldsen, N.M. (author), Pieterse, M.E. (author), Schraagen, J.M.C. (author), Postel, M.G. (author), Vollenbroek-Hutten, M.M.R. (author), de Haan, H.A. (author), Noordzij, M.L. (author)

The current study was a pilot for an alcohol craving monitoring study with a biosensor (E4 wristband) and ecological momentary assessment (EMA) smartphone app. The E4 wristband was evaluated on compliance rates, usability, comfort and stigmatization. Two EMA methodologies (signal- and interval-contingent design) were compared on data variability...

conference paper 2017

document

Alternative proteins: A New Green Revolution: Dietary Proteins From Leaves

Geerdink, P. (author), Diaz, J. (author), de Jong, J. (author), Bussmann, P. (author)

The fractionation and isolation of leaf proteins, mostly in the form of a photosynthetic enzyme, RuBisCO, contributes to improving sustainability and increasing profitability for the agro-industrial sector.

article 2017

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Development of a combined in Vitro Physiologically Based Kinetic (PBK) and Monte Carlo modelling approach to predict interindividual human variation in phenol-induced developmental toxicity

Strikwold, M. (author), Spenkelink, B. (author), Woutersen, R.A. (author), Rietjens, I.M.C.M. (author), Punt, A. (author)

With our recently developed in vitro physiologically based kinetic (PBK) modelling approach, we could extrapolate in vitro toxicity data to human toxicity values applying PBK-based reverse dosimetry. Ideally information on kinetic differences among human individuals within a population should be considered. In the present study, we demonstrated...

article 2017

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The counterintuitive role of extra-column volume in the determination of column efficiency and scaling of chromatographic processes

Schultze-Jena, A. (author), Boon, M.A. (author), Bussmann, P.J.T. (author), Janssen, A.E.M. (author), van der Padt, A. (author)

In industrial liquid separation processes chromatography often has a key function in the optimization of yield and purity. For the design of an industrial system, chromatographic processes are generally simulated using mathematical models, tested and optimized at laboratory level, and then scaled up to pilot and subsequently industrial scale. To...

article 2017

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Verwijdering van gascondensaat uit productiewater

Creusen, R.J.M. (author)

report 2017

document

Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice

Grimaldi, K.A. (author), van Ommen, B. (author), Ordovas, J.M. (author), Parnell, L.D. (author), Mathers, J.C. (author), Bendik, I. (author), Brennan, L. (author), Celis-Morales, C. (author), Cirillo, E. (author), Daniel, H. (author), de Kok, B. (author), El-Sohemy, A. (author), Fairweather-Tait, S.J. (author), Fallaize, R. (author), Fenech, M. (author), Ferguson, L.R. (author), Gibney, E.R. (author), Gibney, M. (author), Gjelstad, I.M.F. (author), Kaput, J. (author), Karlsen, A.S. (author), Kolossa, S. (author), Lovegrove, J. (author), Macready, A.L. (author), Marsaux, C.F.M. (author), Alfredo Martinez, J. (author), Milagro, F. (author), Navas-Carretero, S. (author), Roche, H.M. (author), Saris, W.H.M. (author), Traczyk, I. (author), van Kranen, H. (author), Verschuren, L. (author), Virgili, F. (author), Weber, P. (author), Bouwman, J. (author)

Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of nutrigenetics is the use of personal genetic information to guide recommendations for dietary choices that are more...

article 2017

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Assessment of Determinants of Emission Potentially Affecting the Concentration of Airborne Nano-Objects and Their Agglomerates and Aggregates

Bekker, C. (author), Fransman, W. (author), Boessen, R. (author), Oerlemans, A. (author), Ottenbros, I.B. (author), Vermeulen, R. (author)

Background: Nano-specific inhalation exposure models could potentially be effective tools to assess and control worker exposure to nano-objects, and their aggregates and agglomerates (NOAA). However, due to the lack of reliable and consistent collected NOAA exposure data, the scientific basis for validation of the existing NOAA exposure models...

article 2017

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Clean label product development: involving all stakeholders

Blankestijn, J. (author)

other 2017

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Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge

Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)

Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...

article 2017

document

Systems biology of personalized nutrition

van Ommen, B. (author), van den Broek, T. (author), de Hoogh, I. (author), van Erk, M. (author), van Someren, E. (author), Rouhani-Rankouhi, T. (author), Anthony, J.C. (author), Hogenelst, K. (author), Pasman, W. (author), Boorsma, A. (author), Wopereis, S. (author)

Personalized nutrition is fast becoming a reality due to a number of technological, scientific, and societal developments that complement and extend current public health nutrition recommendations. Personalized nutrition tailors dietary recommendations to specific biological requirements on the basis of a person’s health status and goals. The...

article 2017

document

Towards a food allergy free world

Houben, G. (author)

The international food industry appreciates the benefits of sharing its research load via collaborative programs with partners. TNO offers you the opportunity to participate in its strategic Shared Research Program (SRP) ‘Towards a Food Allergy Free World’.

other 2016

document

Wetgeving novel foods gewijzigd

van den Berg, C. (author), Nieuwland, M. (author), Verhoeckx, K. (author), Heeres, H. (author)

article 2016

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Nitriet in vleesproducten: Kan het wat minder zijn?

Verkleij, T.J. (author)

article 2016

document

Development of immune organs and functioning in humans and testanimals: Implications for immune intervention studies

Kuper, C.F. (author), van Bilsen, J. (author), Cnossen, H. (author), Houben, G. (author), Garthoff, J. (author), Wolterbeek, A. (author)

Ahealthyimmunestatus is mostly determined during early life stages andmanyimmune-related diseases may find their origin in utero and the first years of life. Therefore, immune health optimization may be most effective during early life. This review is an inventory of immune organ maturation events in relation

article 2016

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Relevance of bioaccumulating substances in the TTC concept

Leeman, W.R. (author), Rouhani-Rankouhi, T. (author), Vogels, J. (author), Krul, L. (author)

Recently, the European Food Safety Authority (EFSA) stated that the Threshold of Toxicological Concern

article 2016

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Sensory characteristics of wholegrain and bran-rich cereal foods - A review

Heiniö, R.L. (author), Noort, M.W.J. (author), Katina, K. (author), Alam, S.A. (author), Sozer, N. (author), de Kock, H.L. (author), Hersleth, M. (author), Poutanen, K. (author)

Background: Wholegrain foods are known to be health-beneficial but their sensory characteristics may be a limiting factor for consumption. The scientific literature of factors influencing sensory quality of wholegrain foods is rather scarce. Scope and approach: Many cereals like rye, oats, barley and sorghum are actually used mainly as...

article 2016

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Grain and plant based foods – health aspects, sustainability and future perspectives

van der Kamp, J.W. (author)

conference paper 2016

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Help: Een E-nummer!

Verkleij, T.H. (author)

Het gebruik van additieven bij de bereiding van levensmiddelen blijft de gemoederen bezighouden: de consument wil er zo min mogelijk van, de producent kan ze niet zomaar weglaten en de wetenschap worstelt met het bepalen van de veiligheid van alternatieven. Hoe verder?

article 2016

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Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods (video article)

Westerik, N. (author), Wacoo, A.P. (author), Sybesma1, W. (author), Kort, R. (author)

A novel dried bacterial consortium of Lactobacillus rhamnosus yoba 2012 and Streptococcus thermophilus C106 is cultured in 1 L of milk. This fresh starter can be used for the production of fermented milk and other fermented foods either at home or at small-scale in rural settings. For the fresh starter, 1 L of milk is pasteurized in a pan that...

article 2016

document

Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity

Dols, J.A.M. (author), Molenaar, D. (author), van der Helm, J.J. (author), Caspers, M.P.M. (author), de Kat Angelino-Bart, A. (author), Schuren, F.H.J. (author), Speksnijder, A.G.C.L. (author), Westerhoff, H.V. (author), Richardus, J.H. (author), Boon, M.E. (author), Reid, G. (author), de Vries, H.J.C. (author), Kort, R. (author)

Background: To date, women are most often diagnosed with bacterial vaginosis (BV) using microscopy based Nugent scoring or Amsel criteria. However, the accuracy is less than optimal. The aim of the present study was to confirm the identity of known BV-associated composition profiles and evaluate indicators for BV using three molecular methods....

article 2016