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Eslami Amirabadi, H. (author), Donkers, J.M. (author), Wieringa, E. (author), Ingenhut, B. (author), Pieters, L. (author), Stevens, L. (author), Donkers, T. (author), Westerhout, J. (author), Masereeuw, R. (author), Bobeldijk-Pastorova, I. (author), Nooijen, I. (author), van de Steeg, E. (author)
The majority of intestinal in vitro screening models use cell lines that do not reflect the complexity of the human intestinal tract and hence often fail to accurately predict intestinal drug absorption. Tissue explants have intact intestinal architecture and cell type diversity, but show short viability in static conditions. Here, we present a...
article 2022
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Oude Hengel, K.M. (author), Bouwens, L. (author), in der Maur, M. (author), de Vroome, E. (author), Hooftman, W. (author)
TNO en het CBS monitoren jaarlijks de arbeidssituatie van werkenden in Nederland door middel van de Nationale Enquête Arbeidsomstandigheden (NEA). De NEA is een jaarlijkse meting bij een nieuwe groep representatieve werknemers in Nederland. De NEA volgt veranderingen in het werk en de werkomstandigheden van Nederlanders en de gevolgen ervan voor...
report 2022
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Oude Hengel, K.M. (author), in der Maur, M. (author), Bouwens, L. (author), de Vroome, E. (author), Hooftman, W. (author)
other 2022
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Gentile, G. (author), Bonalumi, D. (author), Pieterse, J.A.Z. (author), Sebastiani, F. (author), Lucking, L.E. (author), Manzolini, G. (author)
The iron and steel industry accounts for 6 % of the global CO2 emissions and it is one of the main hard-to-abate sectors that must be un-locked to reach climate neutrality in the coming decades. The objective of this work is to assess the economics of the FReSMe (From Residual Steel gases to Methanol) process for reducing the carbon footprint of...
article 2022
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Fang, Y. (author), Raat, H. (author), Windhorst, D.A. (author), Fierloos, I.N. (author), Jonkman, H. (author), Hosman, C.M.H. (author), Crone, M.R. (author), Jansen, W. (author), van Grieken, A. (author)
Background: Stressful life events (SLEs) are recognized risk factors for emotional and behavioral problems, but the association is understudied among young children. Our aim was to examine the association between exposure to SLEs and emotional and behavioral problems in young children up to 7 years old. Methods: We analyzed baseline data from...
article 2022
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de Gelder, E. (author), Paardekooper, J.P. (author), Saberi, A.K. (author), Elrofai, H. (author), op den Camp, O.M.G.C. (author), Kraines, S. (author), Ploeg, J. (author), de Schutter, B. (author)
The development of new assessment methods for the performance of automated vehicles is essential to enable the deployment of automated driving technologies, due to the complex operational domain of automated vehicles. One contributing method is scenario-based assessment in which test cases are derived from real-world road traffic scenarios...
conference paper 2022
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Holmberg, A.A. (author), Weidolf, L. (author), Necander, S. (author), Bold, P. (author), Sidhu, S. (author), Pelay-Gimeno, M. (author), de Ligt, R.A.F. (author), Verheij, E.R. (author), Jauhiainen, A. (author), Psallidas, I. (author), Hamrén, U.W. (author), Prothon, S. (author)
This open-label, single-period study describes the human absorption, distribution, metabolism, excretion, and pharmacokinetics of velsecorat (AZD7594). Healthy subjects received inhaled velsecorat (non-radiolabeled; 720 mg) followed by intravenous infusion of carbon 14 (14C)-velsecorat (30 mg). Plasma, urine, and feces were collected up to 168...
article 2022
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Sebastiani, F. (author), Lucking, L.E. (author), Saric, M. (author), James, J.D. (author), Boon, J. (author), van Dijk, H.A.J. (author), Cobden, P. (author), Pieterse, J.A.Z. (author)
Steel production is a main source of CO2 emissions globally. These emissions must be drastically reduced to meet climate change mitigation goals. STEPWISE is a Sorption Enhanced Reactive Process (SERP) technology that converts steel works arising gases to H2 with simultaneous CO2 capture. The main energy requirements of the process are the high-...
article 2022
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Najafi M., (author), Theelen, M. (author), Fledderus, H. (author), Zhang, D. (author), Zardetto, V. (author), van Aken, B. (author), Veenstra, S. (author)
Semitransparent perovskite solar cells (ST-PSCs) are very attractive due to their potential applications in single junctions for building-integrated photovoltaics (BIPV) and in tandem PV technology using low-bandgap bottom solar cells. Despite the high efficiency achieved, the ST-PSCs still suffer low bifaciality, which can limit their overall...
article 2022
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Morgan, A.S. (author), Zeitlin, J. (author), Källén, K. (author), Draper, E.S. (author), Maršál, K. (author), Norman, M. (author), Serenius, F. (author), van Buuren, S. (author), Johnson, S. (author), Benhammou, V. (author), Pierrat, V. (author), Kaminski, M. (author), Foix L'Helias, L. (author), Ancel, P.Y. (author), Marlow, N. (author)
Aim: We investigated the timing of survival differences and effects on morbidity for foetuses alive at maternal admission to hospital delivered at 22 to 26 weeks’ gestational age (GA). Methods: Data from the EXPRESS (Sweden, 2004–07), EPICure-2 (England, 2006) and EPIPAGE-2 (France, 2011) cohorts were harmonised. Survival, stratified by GA, was...
article 2022
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de Bes, J. (author), van Rijn, J.A.M. (author), Moeke, D. (author), Ketelaar, N. (author), Grambergen, P. (author), Lintsen, C. (author), Eijkelkamp, W. (author)
De Nederlandse samenleving staat voor de uitdaging om zorg en sociale ondersteuning toegankelijk en betaalbaar te houden. Lokale overheden, het bedrijfsleven, kennisinstellingen, sociaal werk, welzijns‐, en zorgorganisaties hebben een gezamenlijke verantwoordelijkheid om deze uitdaging het hoofd te bieden. Belangrijke richtinggevende...
report 2022
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Post, J. (author), Ballafkih, H. (author), Sanders, J. (author), van Genabeek, J.A.G.M. (author), Corporaal, S. (author)
Een skillspaspoort is een (digitaal) instrument dat de mogelijkheid biedt om competenties en capaciteiten continu bij te houden en toegang te krijgen tot passende arbeid. Het ontwikkelen en implementeren van skillspaspoorten vormt een complexe opgave, die alleen kans van slagen heeft als het paspoort ook herkend en erkend wordt. Dit rapport doet...
report 2022
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Yang, H. (author), de Wild, P. (author), Lahive, C.W. (author), Wang, Z. (author), Deuss, P.J. (author), Heeres, H.J. (author)
Fast pyrolysis is an efficient technology to convert lignocellulosic biomass to a liquid product. However, the high contents of oxygenated compounds and water hinder the direct utilization of pyrolysis oils. Here, we report an upgrading concept to obtain liquid products with improved product properties and enriched in valuable low molecular...
article 2022
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Brink, S.M. (author), Wortelboer, H. (author), Emmelot, C.H. (author), Visscher, T.L.S. (author), van Wietmarschen, H.A. (author)
Current obesity management strategies are failing to achieve sustainable and favorable long-term results. We propose a more personalized, dynamic, and systemic perspective on the interactions of key determinants and coaching advice on obesity. The aim of this study was to use a systems view on overweight, complexity science, and a...
article 2022
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Aiello, S. (author)
The next generation of water Cherenkov neutrino telescopes in the Mediterranean Sea are under construction offshore France (KM3NeT/ORCA) and Sicily (KM3NeT/ARCA). The KM3NeT/ORCA detector features an energy detection threshold which allows to collect atmospheric neutrinos to study flavour oscillation. This paper reports the KM3NeT/ORCA...
article 2022
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Scheepers, M.J.J. (author), Gamboa Palacios, S. (author), Jegu, E. (author), Pupo Nogueira, L.P. (author), Rutten, L.W. (author), van Stralen, J. (author), Smekens, K.E.L. (author), West, K.J. (author), van der Zwaan, B.C.C. (author)
This paper presents two different scenarios for the energy system of the Netherlands that achieve the Dutch government’s national target of near net-zero greenhouse gas emissions in 2050. Using the system optimisation model OPERA, the authors have analysed the technology, sector and cost implications of the assumptions nderlying these scenarios....
article 2022
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Xue, X. (author), Russ, M. (author), Samkharadze, N. (author), Undseth, B. (author), Sammak, A. (author), Scappucci, G. (author), Vandersypen, L.M.K. (author)
High-fidelity control of quantum bits is paramount for the reliable execution of quantum algorithms and for achieving fault tolerance—the ability to correct errors faster than they occur. The central requirement for fault tolerance is expressed in terms of an error threshold. Whereas the actual threshold depends on many details, a common target...
article 2022
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Noiri, A. (author), Takeda, K. (author), Nakajima, T. (author), Kobayashi, T. (author), Sammak, A. (author), Scappucci, G. (author), Tarucha, S. (author)
Fault-tolerant quantum computers that can solve hard problems rely on quantum error correction1. One of the most promising error correction codes is the surface code, which requires universal gate fidelities exceeding an error correction threshold of 99%. Among the many qubit platforms, only superconducting circuits, trapped ions and nitrogen...
article 2022
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Sahoo, S. (author), van Stralen, J.N.P. (author), Zuidema, C. (author), Sijm, J.P.M. (author), Yamu, C. (author), Faaij, A.P.C. (author)
article 2022
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Deurloo, J.A. (author), van Zoonen, R. (author), van den Braak, A.E.M. (author), Lanting, C.I. (author)
Inleiding: Sinds 1998 zijn er 35 Jeugdgezondheidszorg (JGZ)-richtlijnen ontwikkeld en gepubliceerd. Over het gebruik van richtlijnen door JGZ-professionals in de dagelijkse praktijk is geen recent onderzoek beschikbaar. Methode: Via een digitale vragenlijst is onderzocht of de JGZ-richtlijnen gebruikt worden. Daarnaast is gekeken in hoeverre de...
article 2022
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