(1 - 20 of 212)

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Field, M. (author), Splevins, A. (author), Picaut, P. (author), van der Schans, M. (author), Langenberg, J. (author), Noort, D. (author), Foster, K. (author)
Botulinum neurotoxin type-A (BoNT-A) blocks the release of acetylcholine from peripheral cholinergic nerve terminals and is an important option for the treatment of disorders characterised by excessive cholinergic neuronal activity. Several BoNT-A products are currently marketed, each with unique manufacturing processes, excipients, formulation,...
article 2018
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Walters, C.L. (author), Duvalois, W. (author), Bruchhausen, M. (author), Lapetite, J.M. (author)
article 2016
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den Hartog, E.A. (author), Rubenstein, C.D. (author), Deaton, A.S. (author), Bogerd, C.P. (author)
A major concern for responders to hazardous materials (HazMat) incidents is the heat strain that is caused by fully encapsulated impermeable (NFPA 1991) suits. In a research project, funded by the US Department of Defense, the thermal strain experienced when wearing these suits was studied. Forty human subjects between the ages of 25 and 50...
article 2017
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Jansen, H.W. (author), de Jong, C.A.F. (author)
Thecontributionofshippingnoisetothebackground noise in the seas can be estimated by shipping noise maps. Noise maps can be made by applying appropriate modeling tools for underwater sound propagation and ship source levels to information on the acoustic environment and on the ship traffic in the area of the map. The development of reliable source...
article 2017
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Dittrich, M.G. (author)
De overheid wil negatieve effecten van verkeersgeluid in Nederland aanpakken vanuit een brede visie gericht op de periode tot 2050. Daarvoor is inzicht nodig in de effecten van ontwikkelingen in die periode in beleid, mobiliteit en technologie. TNO heeft een verkennende studie uitgevoerd en daarna een beleidsindicator ontwikkeld waarmee deze...
article 2016
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de Koning, M.C. (author), van Grol, M. (author), Breijaert, T.C. (author)
In recent years, Zr-based metal−organic frameworks (MOFs) have been developed that facilitate catalytic degradation of toxic organophosphate agents, such as chemical warfare agents (CWAs). Because of strict regulations, experiments using live agents are not possible for most laboratories and, as a result, simulants are used in the majority of...
article 2017
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Valle da Silva, J.A. (author), Modesto-Costa, L. (author), de Koning, M.C. (author), Borges, I. (author), Costa França, T.C. (author)
In this work, quaternary and non-quaternary oximes designed to bind at the peripheral site of acetylcholinesterase previously inhibited by organophosphates were investigated theoretically. Some of those oximes have a large number of degrees of freedom, thus requiring an accurate method to obtain molecular geometries. For this reason, the density...
article 2018
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Carmany, D. (author), Walz, A.J. (author), Hsu, F.L. (author), Benton, B. (author), Burnett, D. (author), Gibbons, J. (author), Noort, D. (author), Glaros, T. (author), Sekowski, J.W. (author)
Organophosphorus (OP) nerve agents continue to be a threat at home and abroad during the war against terrorism. Human exposure to nerve agents such as VX results in a cascade of toxic effects relative to the exposure level including ocular miosis, excessive secretions, convulsions, seizures, and death. The primary mechanism behind these overt...
article 2017
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Vilela, S.M.F. (author), Salcedo-Abraira, P. (author), Colinet, I. (author), Salles, F. (author), de Koning, M.C. (author), Joosen, M.J.A. (author), Serre, C. (author), Horcajada, P. (author)
The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH_2 (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe and low-cost synthetic approach (100 °C/32 h under atmospheric pressure) so that for the...
article 2017
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Joosen, M.J.A. (author), van den Berg, R.M. (author), de Jong, A.L. (author), van der Schans, M.J. (author), Noort, D. (author), Langenberg, J.P. (author)
The main goal of the present study was to obtain insight into depot formation and penetration following percutaneous VX poisoning, in order to identify an appropriate decontamination window that can enhance or support medical countermeasures. The study was executed in two phases, using the hairless guinea pig as an animal model. In the first...
article 2017
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Dahl, P.H. (author), de Jong, C.A.F. (author), Popper, A.N. (author)
Impact pile driving is a method used to install piles for marine and inland water construction projects using high-energy impact hammers. The installation of hollow steel piles in this manner can produce extremely high sound levels in the surrounding waters (as well as in the air). Given the large-scale development of off€shore wind in European...
article 2015
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van der Heijden, A.E.D.M. (author), Bouma, R.H.B. (author)
The influence of an explosion-driven deformation on the defect structure in RDX crystals embedded in a polymer-bonded explosive was investigated by means of confocal scanning laser microscopy. The images were compared to the defect structure in the as-received RDX grades, embedded
article 2016
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van der Voort, M.M. (author), Holm, K.B. (author), Kummer, P.O. (author), Teland, J.A. (author), van Doormaal, J.C.A.M. (author), Dijkers, H.P.A. (author)
An important blast injury mechanism is the rupture of the lungs and the gastrointestinal tract. In explosives safety studies and threat analysis the empirical model of Bowen is often used to quantify this mechanism. The original model predicts the lethality for a person in front of a reflecting surface caused by simple Friedlander blast waves....
article 2016
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Li, W.W. (author), Radacsi, N. (author), Kramer, H.J.M. (author), van der Heijden, A.E.D.M. (author), ter Horst, J.H. (author)
When applied to a pure component suspension in an apolar solvent, a strong inhomogeneous electric field induces particle movement, and the particles are collected at the surface of one of the two electrodes. This new phenomenon was used to separately isolate two organic crystalline compounds, phenazine and caffeine, from their suspension in 1,4...
article 2016
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Reus, M.A. (author), van der Heijden, A.E.D.M. (author), ter Horst, J.H. (author)
A method is described for determining the solubility of multicomponent crystalline compounds from clear points upon sample dilution at a constant temperature. Clear points are established by continuously adding a solvent mixture to a suspension of known composition until a clear solution appears. For validation, this solvent addition method is...
article 2015
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Meulenbelt, S.E. (author), Nieuwenhuizen, M.S. (author)
This paper discusses non-State actors’ motivation and capacity to develop and use chemical, biological, radiological or nuclear (CBRN) improvised weapons in attacks, as well as the possible consequences of such use. Six types of groups have been identified as potential CBRN weapons users that may increasingly be able to acquire relevant CBRN...
article 2016
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Harmanny, R.L.A. (author), Prémel-Cabic, G. (author), Wit, J.J.M. (author)
The radar micro-Doppler signature of a target depends on its micro-motion, i.e., the motion of parts of a target relative to the motion of the target as a whole. These micro-motions are very characteristic considering different target classes, e.g., the slow pendulum-like motion of a bird’s wings versus the rapidly rotating propellers of a small...
article 2015
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Wensveen, P.J. (author), von Benda-Beckmann, A.M. (author), Ainslie, M.A. (author), Lam, F.P.A. (author), Kvadsheim, P.H. (author), Tyack, P.L. (author), Miller, P.J.O. (author)
The behaviour of a marine mammal near a noise source can modulate the sound exposure it receives.We demonstrate that two long-finned pilot whales both surfaced in synchrony with consecutive arrivals of multiple sonar pulses. We then assess the effect of surfacing and other behavioural response strategies on the received cumulative sound exposure...
article 2015
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Sliggers, J. (author), Dittrich, M.G. (author)
Geleuidhinder is na luchtverontreiniging het grootste milieuprobleem voor de volksgezonheid. De meeste hinder wordt veroorzaakt door het wegverkeer. Maar liefst 3 miljoen mensen in Nederland zijn gehinderd of slaap gestoord. Ernstig gehinderd of slaapgestoord zijn bijna 1,5 miljoen mensen. Verlaging van de bron-niveaus van de voertuigen en...
article 2015
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Isojunno, S. (author), Curé, C. (author), Helgevold Kvadsheim, P. (author), Lam, F.P.A. (author), Tyack, P.L. (author), Wensveen, P.J. (author), Miller, P.J.O (author)
Abstract . The time and energetic costs of behavioral responses to incidental and experimental sonar exposures, as well as control stimuli, were quantifi ed using hidden state analysis of time series of acoustic and movement data recorded by tags ( DTAG ) attached to 12 sperm whales ( Physeter macrocephalus ) using suction cups. Behavioral state...
article 2016
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