(1 - 20 of 97)

Pages

document
li Piani, T. (author), Weerheijm, J. (author), Peroni, M. (author), Koene, L. (author), Krabbenborg, D. (author), Solomos, G. (author), Sluys, L.J. (author)
This paper presents the results of an experimental research aimed at assessing the material performance of adobe bricks in compression for a wide range of induced strain rates, from statics to high velocity impact. Adobe connotes a traditional masonry whose bricks are made of sundried soil mixtures possibly reinforced with natural fibres and...
article 2020
document
Verheij, E.R. (author), Joosen, M.J.A. (author), Cochrane, L. (author), de Bruin-Hoegée, J.M. (author), de Koning, M.C. (author)
Purpose: This study investigated the decontamination effectiveness of selected toxic industrial chemicals using RSDL® (Reactive Skin Decontamination Lotion Kit; Emergent BioSolutions Inc.; https://www.rsdl.com/). Materials and Methods: Quantitative analytical methods were developed for dermal toxic compounds of varying physicochemical properties...
article 2020
document
Bouma, R.H.B. (author), Griffiths, T.T. (author), Tuukkanen, I.M. (author)
To ensure safety and reliability, it is important that the explosives and other materials used in munitions do not interact adversely either physically or chemically. Data obtained by heat flow calorimetry on nitrocellulose-based propellants have been reviewed with the aim of identifying improved chemical compatibility assessment criteria. It...
article 2019
document
Ozbek, A.S. (author), Pedersen, R.R. (author), Weerheijm, J. (author), van Breugel, K. (author)
This study presents the numerical analyses conducted to investigate the impact behavior of different porous concretes, which have also been cast and tested experimentally. For a realistic representation of the real porous concretes containing arbitrary shaped air pores, a mesh generation code was developed in which the aggregates in the mixtures...
article 2019
document
Field, M. (author), Splevins, A. (author), Picaut, P. (author), van der Schans, M. (author), Langenberg, J. (author), Noort, D. (author), Snyder, D. (author), Foster, K. (author)
article 2019
document
Simons, E.C. (author), Weerheijm, J. (author), Sluys, L.J. (author)
Alumina ceramic is often used in armour systems. This material is known to have a brittle response under tensile loading, while a ductile response is found when sufficiently high pressures are reached. During projectile impact a ceramic material experiences both tensile loading and high pressures, hence fails in both a brittle and ductile way....
article 2019
document
Valle da Silva, J.A. (author), Modesto-Costa, L. (author), de Koning, M.C. (author), Borges, I. (author), Costa França, T.C. (author)
In this work, quaternary and non-quaternary oximes designed to bind at the peripheral site of acetylcholinesterase previously inhibited by organophosphates were investigated theoretically. Some of those oximes have a large number of degrees of freedom, thus requiring an accurate method to obtain molecular geometries. For this reason, the density...
article 2018
document
Bogerd, C.P. (author), Langenberg, J.P. (author), den Hartog, E.A. (author)
Armed forces typically have personal protective clothing (PPC) in place to offer protection against chemical, biological, radiological and nuclear (CBRN) agents. The regular soldier is equipped with permeable CBRN-PPC. However, depending on the operational task, these PPCs pose too much thermal strain to the wearer, which results in a higher...
article 2018
document
Bischoff, L.J.M. (author), Wolters, L. (author), ter Braak, B. (author), Langenberg, J.P. (author), Noort, D. (author), Beltman, J.B. (author), van de Water, B. (author), TNO Defensie en Veiligheid (author)
Oxidative stress leads to the activation of the Nuclear factor-erythroid-2-related factor 2 (Nrf2) pathway. While most studies have focused on the activation of the Nrf2 pathway after single chemical treatment, little is known about the dynamic regulation of the Nrf2 pathway in the context of repeated exposure scenarios. Here we employed single...
article 2018
document
van der Heijden, A.E.D.M. (author)
In the domain of energetic nanomaterials, more specifically nano-sized explosives and oxidizers, many small scale production methods have been explored up to now. So far only limited attempts have been made to scale up the production to tens or maximally a few hunderds of grams. This paper provides a review of these small scale production...
article 2018
document
Meerhoff, G.F. (author), Vester, S.M. (author), Hesseling, P. (author), Klaassen, S.D. (author), Cornelissen, A.S. (author), Lucassen, P.J. (author), Joosen, J.A. (author)
Organophosphate (OP) induced seizures are commonly treated with anticholinergics, oximes and anticonvulsants. Inhibition of P-glycoprotein (PgP) has been shown to enhance the efficacy of nerve agent treatment in soman exposed rats. In the present study, the promising effects of the PgP inhibitor tariquidar were investigated in more detail in...
article 2018
document
Verolme, E.K. (author), van der Voort, M.M. (author), Smits, R. (author), Weerheijm, J. (author), Koh, Y.H. (author), Kang, K.W. (author)
There is limited knowledge on deriving the strength of an explosion based on the observed explosion effects. Existing methods are based primarily on the effects of blast overpressure on surrounding structures. Window breakage and structural damage are well studied and are widely used to derive most probable explosion strengths. Other explosive...
article 2018
document
Joosen, M.J.A. (author), Klaassen, S.D. (author), Verheij, E. (author), van Groningen, T. (author), Cornelissen, A.S. (author), Skiadopoulos, M.H. (author), Cochrane, L. (author), Shearer, J.D. (author)
The efficacy and pharmacokinetics of the aqueous co-formulation contents of the Trobigard™ (atropine sulfate, obidoxime chloride) auto-injector were evaluated in a sarin exposed guinea pig model. Two subcutaneous (sc) sarin challenge doses were evaluated in guinea pigs instrumented with brain and heart electrodes for electroencephalogram (EEG)...
article 2018
document
den Hartog, E.A. (author), Rubenstein, C.D. (author), Deaton, A.S. (author), Bogerd, C.P. (author)
A major concern for responders to hazardous materials (HazMat) incidents is the heat strain that is caused by fully encapsulated impermeable (NFPA 1991) suits. In a research project, funded by the US Department of Defense, the thermal strain experienced when wearing these suits was studied. Forty human subjects between the ages of 25 and 50...
article 2017
document
Jansen, H.W. (author), de Jong, C.A.F. (author)
Thecontributionofshippingnoisetothebackground noise in the seas can be estimated by shipping noise maps. Noise maps can be made by applying appropriate modeling tools for underwater sound propagation and ship source levels to information on the acoustic environment and on the ship traffic in the area of the map. The development of reliable source...
article 2017
document
de Koning, M.C. (author), van Grol, M. (author), Breijaert, T.C. (author)
In recent years, Zr-based metal−organic frameworks (MOFs) have been developed that facilitate catalytic degradation of toxic organophosphate agents, such as chemical warfare agents (CWAs). Because of strict regulations, experiments using live agents are not possible for most laboratories and, as a result, simulants are used in the majority of...
article 2017
document
Carmany, D. (author), Walz, A.J. (author), Hsu, F.L. (author), Benton, B. (author), Burnett, D. (author), Gibbons, J. (author), Noort, D. (author), Glaros, T. (author), Sekowski, J.W. (author)
Organophosphorus (OP) nerve agents continue to be a threat at home and abroad during the war against terrorism. Human exposure to nerve agents such as VX results in a cascade of toxic effects relative to the exposure level including ocular miosis, excessive secretions, convulsions, seizures, and death. The primary mechanism behind these overt...
article 2017
document
Vilela, S.M.F. (author), Salcedo-Abraira, P. (author), Colinet, I. (author), Salles, F. (author), de Koning, M.C. (author), Joosen, M.J.A. (author), Serre, C. (author), Horcajada, P. (author)
The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH_2 (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe and low-cost synthetic approach (100 °C/32 h under atmospheric pressure) so that for the...
article 2017
document
Joosen, M.J.A. (author), van den Berg, R.M. (author), de Jong, A.L. (author), van der Schans, M.J. (author), Noort, D. (author), Langenberg, J.P. (author)
The main goal of the present study was to obtain insight into depot formation and penetration following percutaneous VX poisoning, in order to identify an appropriate decontamination window that can enhance or support medical countermeasures. The study was executed in two phases, using the hairless guinea pig as an animal model. In the first...
article 2017
document
Tedeschi, G. (author), van Eijk, A.M.J. (author), Piazzolla, J. (author), Kusmierczyk-Michulec, J.T. (author)
Sea-salt aerosol concentrations in the coastal zone are assessed with the numerical aerosol-transport model MACMod that applies separate aerosol source functions for open ocean and the surf zone near the sea–land transition. Numerical simulations of the aerosol concentration as a function of offshore distance from the surf zone compare...
article 2017
(1 - 20 of 97)

Pages