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li Piani, T. (author), Weerheijm, J. (author), Peroni, M. (author), Koene, L. (author), Krabbenborg, D. (author), Solomos, G. (author), Sluys, L.J. (author)
This paper presents the results of an experimental research aimed at assessing the material performance of adobe bricks in compression for a wide range of induced strain rates, from statics to high velocity impact. Adobe connotes a traditional masonry whose bricks are made of sundried soil mixtures possibly reinforced with natural fibres and...
article 2020
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Verheij, E.R. (author), Joosen, M.J.A. (author), Cochrane, L. (author), de Bruin-Hoegée, J.M. (author), de Koning, M.C. (author)
Purpose: This study investigated the decontamination effectiveness of selected toxic industrial chemicals using RSDL® (Reactive Skin Decontamination Lotion Kit; Emergent BioSolutions Inc.; https://www.rsdl.com/). Materials and Methods: Quantitative analytical methods were developed for dermal toxic compounds of varying physicochemical properties...
article 2020
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Bouma, R.H.B. (author), Griffiths, T.T. (author), Tuukkanen, I.M. (author)
To ensure safety and reliability, it is important that the explosives and other materials used in munitions do not interact adversely either physically or chemically. Data obtained by heat flow calorimetry on nitrocellulose-based propellants have been reviewed with the aim of identifying improved chemical compatibility assessment criteria. It...
article 2019
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Philippens, M.M.G.M.M. (author), Ouellet, S. (author)
bookPart 2019
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Ozbek, A.S. (author), Pedersen, R.R. (author), Weerheijm, J. (author), van Breugel, K. (author)
This study presents the numerical analyses conducted to investigate the impact behavior of different porous concretes, which have also been cast and tested experimentally. For a realistic representation of the real porous concretes containing arbitrary shaped air pores, a mesh generation code was developed in which the aggregates in the mixtures...
article 2019
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Field, M. (author), Splevins, A. (author), Picaut, P. (author), van der Schans, M. (author), Langenberg, J. (author), Noort, D. (author), Snyder, D. (author), Foster, K. (author)
article 2019
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Simons, E.C. (author), Weerheijm, J. (author), Sluys, L.J. (author)
Alumina ceramic is often used in armour systems. This material is known to have a brittle response under tensile loading, while a ductile response is found when sufficiently high pressures are reached. During projectile impact a ceramic material experiences both tensile loading and high pressures, hence fails in both a brittle and ductile way....
article 2019
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Li Piani, T. (author), Weerheijm, J. (author), Koene, L. (author), Sluys, L.J. (author)
A local damage model is proposed for the numerical assessment of the static performance of Adobe masonry components. The model was applied to simulate the experimental behaviour of sundried soil bricks and mud mortar tested in uniaxial compression and bending. Numerical simulations of the model are made mesh objective by means of a rate...
article 2019
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Scholtes, J.H.G. (author)
For fragment impact and sympathetic reaction calculations, a variety of empirical and simple 1D-shock models have been developed. Some of these, like the Walker-Wasley or the Cook-Haskins-James model, use a simple critical energy criterion. The empirical Jacobs-Roslund model has a large database and is well-known in the explosive community for...
conference paper 2019
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Field, M. (author), Splevins, A. (author), Picaut, P. (author), van der Schans, M. (author), Langenberg, J. (author), Noort, D. (author), Foster, K. (author)
Botulinum neurotoxin type-A (BoNT-A) blocks the release of acetylcholine from peripheral cholinergic nerve terminals and is an important option for the treatment of disorders characterised by excessive cholinergic neuronal activity. Several BoNT-A products are currently marketed, each with unique manufacturing processes, excipients, formulation,...
article 2018
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Valle da Silva, J.A. (author), Modesto-Costa, L. (author), de Koning, M.C. (author), Borges, I. (author), Costa França, T.C. (author)
In this work, quaternary and non-quaternary oximes designed to bind at the peripheral site of acetylcholinesterase previously inhibited by organophosphates were investigated theoretically. Some of those oximes have a large number of degrees of freedom, thus requiring an accurate method to obtain molecular geometries. For this reason, the density...
article 2018
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Veraar, R.G. (author), Wieling, W.P.W. (author)
Solid Fuel Ramjet (SFRJ) technology is a very attractive propulsion option to extend the range of gun launched projectiles mainly due to the combination of high specific impulse inherent to airbreathing propulsion and mechanical properties of the solid fuel capable of withstanding the very high launch loads in the gun. In 2004, the Netherlands...
conference paper 2018
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report 2018
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White, A. (author)
Responding to an operating environment characterised by both low- and high-intensity operations, armed forces continue to consider multiple avenues to enhance the protection and mobility of personnel across the battlespace.
article 2018
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Bogerd, C.P. (author), Langenberg, J.P. (author), den Hartog, E.A. (author)
Armed forces typically have personal protective clothing (PPC) in place to offer protection against chemical, biological, radiological and nuclear (CBRN) agents. The regular soldier is equipped with permeable CBRN-PPC. However, depending on the operational task, these PPCs pose too much thermal strain to the wearer, which results in a higher...
article 2018
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Bischoff, L.J.M. (author), Wolters, L. (author), ter Braak, B. (author), Langenberg, J.P. (author), Noort, D. (author), Beltman, J.B. (author), van de Water, B. (author), TNO Defensie en Veiligheid (author)
Oxidative stress leads to the activation of the Nuclear factor-erythroid-2-related factor 2 (Nrf2) pathway. While most studies have focused on the activation of the Nrf2 pathway after single chemical treatment, little is known about the dynamic regulation of the Nrf2 pathway in the context of repeated exposure scenarios. Here we employed single...
article 2018
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van der Heijden, A.E.D.M. (author)
In the domain of energetic nanomaterials, more specifically nano-sized explosives and oxidizers, many small scale production methods have been explored up to now. So far only limited attempts have been made to scale up the production to tens or maximally a few hunderds of grams. This paper provides a review of these small scale production...
article 2018
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Meerhoff, G.F. (author), Vester, S.M. (author), Hesseling, P. (author), Klaassen, S.D. (author), Cornelissen, A.S. (author), Lucassen, P.J. (author), Joosen, J.A. (author)
Organophosphate (OP) induced seizures are commonly treated with anticholinergics, oximes and anticonvulsants. Inhibition of P-glycoprotein (PgP) has been shown to enhance the efficacy of nerve agent treatment in soman exposed rats. In the present study, the promising effects of the PgP inhibitor tariquidar were investigated in more detail in...
article 2018
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de Koning, M.C. (author), Horn, G. (author), van Grol, M. (author)
Organophosphorous (OP) compounds (such as nerve agents) inhibit the enzyme acetylcholinesterase (AChE) by covalent phosphylation of a key serine residue in the active site of the enzyme resulting in severe symptoms and ultimately death. OP intoxications are currently treated by administration of certain oxime compounds. The presently fielded...
conference paper 2018
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Verolme, E.K. (author), van der Voort, M.M. (author), Smits, R. (author), Weerheijm, J. (author), Koh, Y.H. (author), Kang, K.W. (author)
There is limited knowledge on deriving the strength of an explosion based on the observed explosion effects. Existing methods are based primarily on the effects of blast overpressure on surrounding structures. Window breakage and structural damage are well studied and are widely used to derive most probable explosion strengths. Other explosive...
article 2018
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