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van den Dries, M.A. (author), Lamballais, S. (author), El Marroun, H. (author), Pronk, A. (author), Spaan, S. (author), Ferguson, K.K. (author), Longnecker, M.P. (author), Tiemeier, H. (author), Guxens, M. (author)
Background: Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine...
article 2020
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Liu, Y. (author), Toet, A. (author), Krone, T. (author), van Stokkum, R. (author), Eijsman, S. (author), van Erp, J.B.F. (author)
The affective appraisal of odors is known to depend on their intensity (I), familiarity (F), detection threshold (T), and on the baseline affective state of the observer. However, the exact nature of these relations is still largely unknown. We therefore performed an observer experiment in which participants (N = 52) smelled 40 different odors ...
article 2020
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Hoevenaars, F.P.M. (author), Berendsen, C.M.M. (author), Pasman, W.J. (author), van den Broek, T.J. (author), Barrat, E. (author), de Hoogh, I.M. (author), Wopereis, S. (author)
In public health initiatives, generic nutrition advice (GNA) from national guidelines has a limited effect on food-intake improvement. Personalized nutrition advice (PNA) may enable dietary behavior change. A monocentric, randomized, parallel, controlled clinical trial was performed in males (n = 55) and females (n = 100) aged 25 to 70 years....
article 2020
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Hendriks, H. (author), van de Rest, O. (author), Snippe, A. (author), Kieboom, J. (author), Hogenelst, K. (author)
Long-term alcohol abuse is associated with poorer cognitive performance. However, the associations between light and moderate drinking and cognitive performance are less clear. We assessed this association via cross-sectional and longitudinal analyses in a sample of 702 Dutch students. At baseline, alcohol consumption was assessed using...
article 2020
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Verlinden, D.A. (author), Schuller, A.A. (author), Verrips, G.H.W. (author), Reijneveld, S.A. (author)
Young children rely on their parents with respect to oral health routines. However, parental knowledge on this topic is often insufficient. Well-child care may be an excellent route to reach parents because almost all of them attend. To evaluate the effectiveness of an 8.5 min web-based film about oral health, provided by well-child care, a non...
article 2020
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Schoen, E.D. (author), Wopereis, S. (author)
BACKGROUND: Parallel intervention studies involving volunteers usually require a procedure to allocate the subjects to study-arms. Statistical models to evaluate the different outcomes of the study-arms will include study-arm as a factor along with any covariate that might affect the results. To ensure that the effects of the covariates are...
article 2020
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Bouwhuis, S. (author), Geuskens, G.A. (author), Boot, C.R.L. (author), van der Beek, A.J. (author), Bongers, P.M. (author)
Introduction Precarious employment is associated with poor health. Among employees in precarious employment, those with multiple jobs may face additional health risks, e.g. due to combining work schedules and job roles. Our research question is: do differences in health exist between multiple and single job holders in precarious employment?...
article 2019
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Huijs, J.J.J.M. (author), Houtman, I.L.D. (author), Taris, T.W. (author), Blonk, R.W.B. (author)
Background The present study aimed to investigate the effects of a stepwise, bottom-up participatory program with a tailor-made intervention process addressing the level of mental retirement in a sample of Dutch employees. Mental retirement refers to feelings of being disconnected from your work and your organization. Prevention of mental...
article 2019
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Tielman, M.L. (author), Neerincx, M.A. (author), Pagliari, C. (author), Rizzo, A. (author), Brinkman, W.P. (author)
Background: Digital health interventions can fill gaps in mental healthcare provision. However, autonomous e-mental health (AEMH) systems also present challenges for effective risk management. To balance autonomy and safety, AEMH systems need to detect risk situations and act on these appropriately. One option is sending automatic alerts to...
article 2019
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Vink, R.M. (author), van Dommelen, P. (author), van der Pal, S.M. (author), Eikhout, I. (author), Pannebakker, F.D. (author), Klein Velderman, M. (author), Haagmans, M. (author), Mulder, T. (author), Dekker, M. (author)
Background Adverse Childhood Experiences (ACEs) may have a life-long impact on mental health and are related to physical disease, such as diabetes and cardiovascular diseases in adulthood. Research on ACEs suffers from recall bias when performed with adults. Objective To estimate the prevalence of ACEs and the interrelationships between ACEs as...
article 2019
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Viester, L. (author), Verhagen, E.A.L.M. (author), Bongers, P.M. (author), van der Beek, A.J. (author)
Purpose: To evaluate the effectiveness of an individually tailored intervention for improvement in lifestyle behavior, health indicators, and prevention and reduction of overweight among construction workers. Design: Randomized controlled trial. Setting: Various blue-collar departments of a large construction company in the Netherlands....
article 2018
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de Groot, J.F. (author), Damen, N. (author), de Loos, E. (author), Goorhuis, J. (author), Wagner, C. (author)
Background: Paediatric Early Warning Scores (PEWS) are increasingly being used for early identification and management of clinical deterioration in paediatric patients. A PEWS system includes scores, cut-off points and appropriate early intervention. In 2011, The Dutch Ministry of Health advised hospitals to implement a PEWS system in order to...
article 2018
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Fallaize, R. (author), Livingstone, K.M. (author), Celis-Morales, C. (author), Macready, A.L. (author), San-Cristobal, R. (author), Navas-Carretero, S. (author), Marsaux, C.F.M. (author), O’Donovan, C.B. (author), Kolossa, S. (author), Moschonis, G. (author), Walsh, M.C. (author), Gibney, E.R. (author), Brennan, L. (author), Bouwman, J. (author), Manios, Y. (author), Jarosz, M. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gundersen, T.E. (author), Drevon, C.A. (author), Gibney, M.J. (author), Mathers, J.C. (author), Lovegrove, J.A. (author)
Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore,...
article 2018
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Blanson Henkemans, O.A. (author), Keij, M. (author), Grootjen, M. (author), Kamphuis, M. (author), Dijkshoorn, A. (author)
Background: The StartingTogether program (in Dutch SamenStarten) is a family-centred method for early identification of social-emotional and behavioural problems in young children. Nurses in preventive child health care find it challenging to: determine family issues and need for care; provide education; refer to social services; increase parent...
article 2018
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Siemonsma, P.C. (author), Blom, J.W. (author), Hofstetter, H. (author), van Hespen, A.T.H. (author), Gussekloo, J. (author), Drewes, Y.M. (author), van Meeteren, N.L.U. (author)
Background: A physically active lifestyle in older people contributes to the preservation of good health. We assessed the influence of physiotherapy on daily functioning among community dwelling older people (75+) with complex health problems identified with screening, versus usual care. We also compared functional task exercise (FTE), with...
article 2018
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Reijnen, A. (author), Geuze, E. (author), Eekhout, I. (author), Maihofer, A.X. (author), Nievergelt, C.M. (author), Baker, D.G. (author), Vermetten, E. (author)
In order to decrease the risk of developing stress-related disorders after military deployment, biological vulnerability factors should be identified. Neuropeptide Y (NPY) is a peptide neurotransmitter that is associated with modulation of the stress response. Using the data of two longitudinal prospective cohort studies (N = 892 and N = 2427),...
article 2018
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Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)
Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...
article 2018
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van Groen, B.D. (author), van de Steeg, E. (author), Mooij, M.G. (author), van Lipzig, M.M.H. (author), de Koning, B.A.E. (author), Verdijk, R.M. (author), Wortelboer, H.M. (author), Gaedigk, R. (author), Bi, C. (author), Leeder, S. (author), van Schaik, R.H.N. (author), van Rosmalen, J. (author), Tibboel, D. (author), Vaes, W.H. (author), de Wildt, S.N. (author)
Background Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples. Methods Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3,...
article 2018
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Kruisdijk, F. (author), Deenik, J. (author), Yenback, D. (author), Tak, E.C. (author), van Harten, P. (author), Hopman-Rock, M. (author), Hendriksen, I. (author)
Sedentary behaviour and lack of physical activity threatens health. Research concerning these behaviours of inpatients with severe mental illness is limited but urgently needed to reveal prevalence and magnitude. In total, 184 inpatients (men n =108, women n =76, mean age 57,4, 20% first generation antipsychotics, 40% second generation...
article 2017
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Boesveld, I.C. (author), Valentijn, P.P. (author), Hitzert, M. (author), Hermus, M.A.A. (author), Franx, A. (author), de Vries, R.G. (author), Wiegers, T.A. (author), Bruijnzeels, M.A. (author)
Introduction: Integrated care is considered to be a means to reduce costs, improve the quality of care and generate better patient outcomes. At present, little is known about integrated care in maternity care systems. We developed questionnaires to examine integrated care in two different settings, using the taxonomy of the Rainbow Model of...
article 2017
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