(1 - 20 of 24)

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Schrieks, I.C. (author), Heil, A.L. (author), Hendriks, H.F. (author), Mukamal, K.J. (author), Beulens, J.W. (author)
OBJECTIVE: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. This reduced risk might be explained by improved insulin sensitivity or improved glycemic status, but results of intervention studies on this relation are inconsistent. The purpose of this study was to conduct a systematic review and meta-analysis of...
article 2015
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Beulens, J.W.J. (author), de Zoete, E.C. (author), Kok, F.J. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Objective: Moderate alcohol consumption is associated with a decreased risk of type II diabetes. This study investigates the effect of moderate alcohol consumption on adipokines and insulin sensitivity. Subjects: Twenty healthy, lean (body mass index (BMI) 18.5-25 kg/m2; n=11) or overweight (BMI>27 kg/m2; n=9) men (18-25 years). Methods: Three...
article 2008
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Beulens, J.W.J. (author), van den Berg, R. (author), Kok, F.J. (author), Helander, A. (author), Vermunt, S.H.F. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Background and aims: To investigate the effect of moderate alcohol consumption on lipoprotein-associated phospholipase A2 activity, markers of inflammation and oxidative stress and whether these effects are modified by BMI. Methods and results: Eleven lean (BMI: 18.5-25 kg/m2) and 9 overweight (BMI > 27 kg/m2) men participated in a randomized...
article 2008
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Beulens, J.W.J. (author), Rimm, E.B. (author), Hendriks, H.F.J. (author), Hu, F.B. (author), Manson, J.E. (author), Hunter, D.J. (author), Mukamal, K.J. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE - We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes. RESEARCH DESIGN AND METHODS - In nested case-control studies of 640 women with incident diabetes and 1,000 control subjects from the Nurses' Health Study and 383 men...
article 2007
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Beulens, J.W.J. (author), van Loon, L.J.C. (author), Kok, F.J. (author), Pelsers, M. (author), Bobbert, T. (author), Spranger, J. (author), Helander, A. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Aims/hypothesis: The aim of this study was to investigate whether moderate alcohol consumption increases plasma high molecular weight (HMW) adiponectin and/or muscle oxidative capacity. Materials and methods: Eleven lean (BMI 18-25 kg/m2) and eight overweight (BMI ≥27 kg/m2) men consumed 100 ml whisky (∼32 g alcohol) or water daily for 4 weeks...
article 2007
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Beulens, J.W.J. (author), Rimm, E.B. (author), Ascherio, A. (author), Spiegelman, D. (author), Hendriks, H.F.J. (author), Mukamal, K.J. (author), TNO Kwaliteit van Leven (author)
Background: Heavy alcohol consumption increases risk for hypertension, which is in itself a strong risk factor for cardiovascular disease (CVD). However, data on the association between alcohol consumption and CVD among individuals with hypertension are scarce. Objective: To assess whether alcohol consumption is inversely associated with CVD...
article 2007
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Koppes, L.L.J. (author), Dekker, J.M. (author), Hendriks, H.F.J. (author), Bouter, L.M. (author), Heine, R.J. (author), TNO Kwaliteit van Leven (author)
Aims/hypothesis: This systematic review examines the relationship between alcohol consumption and long-term complications of type 2 diabetes. Meta-analyses could only be performed for total mortality, mortality from CHD, and CHD incidence, because the availability of articles on other complications was too limited. Materials and methods: A...
article 2006
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Beulens, J.W.J. (author), van Beers, R.M. (author), Stolk, R.P. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Objective: To investigate the effect of moderate alcohol consumption on fat distribution, adipose tissue secreted proteins (adiponectin and resistin), and insulin sensitivity in healthy middle-aged men with abdominal obesity. Research Methods and Procedures: Thirty-four healthy men between 35 and 70 years old, with increased waist circumference ...
article 2006
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van Trijp, M.J.C.A. (author), Beulens, J.W.J. (author), Bos, W.J.W. (author), Uiterwaal, C.S.P.M. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), Bots, M.L. (author), TNO Kwaliteit van Leven (author)
Background: Light-to-moderate alcohol consumption is associated with a decreased risk of ischemic cardiovascular disease, whereas increased alcohol intake is related to hypertension and intracerebral hemorrhage. We studied the effect of alcohol consumption on the augmentation index (AIx), a measure of arterial wave reflection in a population of...
article 2005
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van den Elzen, A.P. (author), Sierksma, A. (author), Oren, A. (author), Vos, L.E. (author), Witteman, J.C. (author), Grobbee, D.E. (author), Hendriks, H.F. (author), Uiterwaal, C.S. (author), Bots, M.L. (author), TNO Kwaliteit van Leven (author)
Background: Moderate alcohol consumption has been shown to protect against cardiovascular disease. Aortic stiffness can be regarded as a marker of cardiovascular disease risk. Previously we have shown an inverse to J-shaped association between alcohol intake and aortic stiffness in middle-aged and elderly men and postmenopausal women. Objective:...
article 2005
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Sierksma, A. (author), Sarkola, T. (author), Eriksson, C.J.P. (author), van der Gaag, M.S. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), TNO Voeding (author)
Background: Moderate alcohol consumption is inversely associated with cardiovascular diseases. Changes in hormone levels might in part help explain the positive health effect. This study was performed to examine the effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate (DHEAS), testosterone, and estradiol levels....
article 2004
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Sierksma, A. (author), Patel, H. (author), Ouchi, N. (author), Kihara, S. (author), Funahashi, T. (author), Heine, R.J. (author), Grobbee, D.E. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Preventie en Gezondheid (author)
OBJECTIVE - Epidemiological studies suggest that moderate alcohol consumers have enhanced insulin sensitivity and a reduced risk of type 2 diabetes. Adiponectin, an adipocyte-derived plasma protein, has been found to be negatively associated with adiposity and positively associated with insulin sensitivity. Moderate alcohol consumption may...
article 2004
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Beulens, J.W.J. (author), Sierksma, A. (author), van Tol, A. (author), Fournier, N. (author), van Gent, T. (author), Paul, J.L. (author), Hendriks, H.F.J. (author), TNO Voeding (author)
Moderate alcohol consumption increases HDL cholesterol, which is involved in reverse cholesterol transport (RCT). The aim of this study was to investigate the effect of moderate alcohol consumption on cholesterol efflux, using J774 mouse macrophages and Fu5AH cells, and on other parameters in the RCT pathway. Twenty-three healthy men (45-65...
article 2004
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Sierksma, A. (author), Muller, M. (author), van der Schouw, Y.T. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), Bots, M.L. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between...
article 2004
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Markus, C.R. (author), Sierksma, A. (author), Verbeek, C. (author), van Rooijen, J.J.M. (author), Patel, H.J. (author), Brand, A.N. (author), Hendriks, H.F.J. (author), TNO Voeding (author)
Brain serotonin (5-HT) synthesis is controlled by nutrients that influence the availability of plasma tryptophan (Trp) as compared with the sum of the other large neutral amino acids (LNAA; Trp:LNAA). Alcohol consumption is found to change mood and performance and this might well be due to alterations in the plasma Trp:LNAA ratio and brain 5-HT....
article 2004
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Sierksma, A. (author), van der Gaag, M.S. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author)
1. The present study investigated the acute and chronic effect of dinner with alcoholic beverages on serum nitric oxide (NO) metabolites, namely nitrate and nitrite (NOx), in 11 healthy, non-smoking middle-aged men. 2. In a randomized, diet-controlled, cross-over trial, subjects consumed dinner with four glasses of red wine, beer, spirits (Dutch...
article 2003
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Sierksma, A. (author), van der Gaag, M.S. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Voeding (author)
Objective: To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen. Design: Randomized, diet-controlled, cross-over study. Setting: The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands. Subjects: Ten middle-aged men and 10 postmenopausal women, all...
article 2002
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Sierksma, A. (author), van der Gaag, M.S. (author), van Tol, A. (author), James, R.W. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: The inverse association between moderate drinking and coronary heart disease mortality is well established. This study was performed to investigate the kinetics of the alcohol-induced increases in apo A-1, HDL cholesterol, and paraoxonase (PON) activity, as well as to study whether the alcohol-induced increases in PON activity differ...
article 2002
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Hendriks, H.F.J. (author), van Haaren, M.R.T. (author), Leenen, R. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Moderate alcohol consumption is associated with a reduced coronary heart disease (CHD) risk. Epidemiologic studies have provided conflicting data which suggests that CHD protection may be modulated or may not be modulated by a person's CHD risk profile. Methods: We examined the effects of moderate alcohol consumption (35 g/day) on...
article 2001
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van der Gaag, M.S. (author), van Tol, A. (author), Vermunt, S.H.F. (author), Scheek, L.M. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Alcohol consumption is associated with increased HDL cholesterol levels, which may indicate stimulated reverse cholesterol transport. The mechanism is, however, not known. The aim of this study was to evaluate the effects of alcohol consumption on the first two steps of the reverse cholesterol pathway: cellular cholesterol efflux and plasma...
article 2001
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