(1 - 20 of 36)

Pages

document
Arts, J.H.E. (author), Mojet, J. (author), van Gemert, L.J. (author), Emmen, H.H. (author), Lammers, J.H.C.M. (author), Marquart, J. (author), Woutersen, R.A. (author), Feron, V.J. (author), TNO Voeding (author)
Studies on the irritative effects of acetone vapor in humans and experimental animals have revealed large differences in the lowest acetone concentration found to be irritative to the respiratory tract and eyes. This has brought on much confusion in the process of setting occupational exposure limits for acetone. A literature survey was carried...
article 2002
document
Feron, V.J. (author), Kittel, B. (author), Kuper, C.F. (author), Ernst, H. (author), Rittinghausen, S. (author), Muhle, H. (author), Koch, W. (author), Gamer, A. (author), Mallett, A.K. (author), Hoffmann, H.D. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Two independent bioassays are available which have examined the potential carcinogenicity of monomeric and polymeric methylene diphenyl diisocyanate (MDI) following long-term inhalation exposure in rats. These studies are not directly comparable, however, due to differences in design and conduct of the in-life phase, and differences in...
article 2001
document
Krul, C.A.M. (author), Luiten-Schuite, A. (author), Baan, R. (author), Verhagen, H. (author), Mohn, G. (author), Feron, V. (author), Havenaar, R. (author)
The TNO gastro-Intestinal tract Model (TIM) is a dynamic computer-controlled in vitro system that mimics the human physiological conditions in the stomach and small intestine. In the current TIM physiological parameters such as pH, temperature, peristaltic movements, secretion of digestion enzymes, bile and pancreatic juices, and absorption of...
article 2000
document
Clary, J.J. (author), Feron, V.J. (author), van Velthuijsen, J.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Lactate eaters have an oral LD50 greater than 2000 mg/kg and the inhalation LC50 is generally above 5000 mg/m3 and they may be potential eye and skin irritants, but not skin sensitizers. No evidence of teratogenicity or maternal toxicity was observed in an inhalation (2-ethylhexyl-L-lactate) or dermal study (ethyl-L-lactate). Subacute inhalation...
article 1998
document
Cassee, F.R. (author), Groten, J.P. (author), van Bladeren, P.J. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A major objective of combination toxicology is to establish whether a mixture of chemicals will result in an effect similar to that expected on the basis of additivity. This requires understanding of the basic concepts of the combined toxicological action of the compounds of the mixture: simple similar action (dose addition), simple dissimilar...
article 1998
document
Groten, J.P. (author), Schoen, E.D. (author), van Bladeren, P.J. (author), Kuper, C.F. (author), van Zorge, J.A. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The present study was intended (1) to find out whether simultaneous administration of nine chemicals at a concentration equal to the 'no-observed-adverse-effect level' (NOAEL) for each of them would result in a NOAEL for the combination and (2) to test the usefulness of fractionated factorial models to detect possible interactions between...
article 1997
document
Cassee, F.R. (author), Groten, J.P. (author), Feron, V.J. (author), TNO Voeding (author)
Formaldehyde, acetaldehyde, and acrolein are well-known upper respiratory tract irritants and occur simultaneously as pollutants in many indoor and outdoor environments. The upper respiratory tract, and especially the nose, is the prime target for inhaled aldehydes. To study possible additive or interactive effects on the nasal epithelium we...
article 1996
document
Jonker, D. (author), Woutersen, R.A. (author), Feron, V.J. (author), TNO Voeding (author)
The toxicity of mixtures of chemicals with the same target organ was examined in rats using nephrotoxicants with similar or dissimilar modes of action. In a 4-wk feeding study, lysinoalanine, mercuric chloride, hexachloro-1,3-butadiene and d-limonene, each affecting renal proximal tubular cells but through different modes of action, were...
article 1996
document
Groten, J.P. (author), Schoen, E.D. (author), Feron, V.J. (author), TNO Voeding (author)
The use of factorial designs, in which n chemicals are studied at x(n) dose levels (x treatment groups), has been put forward as one of the valuable statistical approaches for hazard assessment of chemical mixtures. Very recently a '25 study' was presented to describe interactions between the carcinogenic activity of five polycyclic aromatic...
article 1996
document
Cassee, F.R. (author), Arts, J.H.E. (author), Groten, J.P. (author), Feron, V.J. (author)
Sensory irritation of formaldehyde (FRM), acrolein (ACR) and acetaldehyde (ACE) as measured by the decrease in breathing frequency (DBF) was studied in male Wistar rats using nose-only exposure. Groups of four rats were exposed to each of the single compounds separately or to mixtures of FRM, ACR and/or ACE. Exposure concentrations of the...
article 1996
document
Wolterbeek, A.P.M. (author), Roggeband, R. (author), Baan, R.A. (author), Feron, V.J. (author), Rutten, A.A.J.J.L. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Vitamin A and β-carotene protect against respiratory tract cancer by inhibiting the formation of DNA damage and controlling cellular proliferation and differentiation, Recently, it has been shown that the p53 tumor-suppressor gene plays a crucial role in the etiology of respiratory tract cancer. In the present study, we investigated the...
article 1995
document
van Nesselrooij, J.H.J. (author), Bruijntjes, J.P. (author), Garderen van-Hoetmer, A. (author), Tillapaugh-Fay, G.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Estrogen-induced pituitary lesions in rats were studied in time-sequence experiments using magnetic resonance imaging (MRI), hormone determinations and light microscopy. The main purpose of the study was to evaluate the usefulness of MRI in comparison with conventional biochemical and histopathological methods for detecting the pituitary lesions...
article 1991
document
Zwart, A. (author), Woutersen, R.A. (author), Wilmer, J.W.G.M. (author), Spit, B.J. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To study in detail possible effects of low concentrations of formaldehyde on the nasal epithelium, Wistar rats were exposed to 0, 0.3, 1 and 3 ppm formaldehyde vapour for 6 h/day, 5 days/week during 3 days or 13 weeks, using in vivo [3H]thymidine labeling for cell proliferation studies, and light and electron microscopy for detecting...
article 1988
document
de Groot, A.P. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In previous studies we observed an increased incidence of hyperplasia in the epithelium of the urinary bladder of rats fed cereal-based stock diet supplemented with 6% monosodium glutamate (MSG) for 3 months. Hyperplasia was not enhanced, however, when 6% MSG was fed in a purified casein diet. Further studies have been conducted to identify the...
article 1988
document
Feron, V.J. (author), Bruyntjes, J.P. (author), Woutersen, R.A. (author), Immel, H.R. (author), Appelman, L.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Male Wistar rats were exposed to 0, 10 or 20 ppm formaldehyde vapour for 4, 8 or 13 weeks (6 h/day; 5 days/week), and were then observed for periods up to 126 weeks. Transient growth retardation occurred in both test groups. Death rate was not noticeably affected by formaldehyde. Despite recovery periods of at most 126 weeks, the nasal...
article 1988
document
van Graft, M. (author), Spit, B.J. (author), Immel, H.R. (author), Feron, V.J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
In a one-year serial sacrifice study 10 mg glass fibres (length, 95% ?? 20 ??m, 89% ?? 12 ??m, 58% ?? 5 ??m and 25% ?? 2 ??m; diameter, 88% ?? 1.0 ??m, 60% ?? 0.5 ??m and 31% ??0.25 ??m) suspended in 0.2 ml saline solution were administered to Syrian golden hamsters by a single intratracheal instillation to determine the clearance of the glass...
article 1986
document
Til, H.P. (author), Feron, V.J. (author), Immel, H.R. (author), Vogel, W.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
article 1986
document
Appelman, L.M. (author), Woutersen, R.A. (author), Feron, V.J. (author), Hooftman, R.N. (author), Notten, W.R.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects of exposure pattern on the toxicity of acetaldehyde vapour were investigated in 4-week inhalation studies. Male rats were exposed to 500 or 150 and 110 ppm for 6 h per day/5 days per week. One group of animals was exposed without interruption, the exposure of a second group was interrupted for 1.5 h between the first and second 3-h...
article 1986
document
Reynders, J.B.J. (author), Immel, H.R. (author), Scherrenberg, P.M. (author), Feron, V.J. (author), Beems, R.B. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Two groups of male and female Syrian golden hamsters, of which the trachea was severely injured by electrocoagulation, received 6 weekly intratracheal instillations of benzo[a]pyrene (BaP) + ferric oxide in saline or saline alone. Two comparable groups of hamsters were similarly treated but had an undamaged trachea. The experiment was terminated...
article 1985
document
Feron, V.J. (author), Scherrenberg, P.M. (author), Immel, H.R. (author), Spit, B.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Syrian golden hamsters were given intratracheal instillations of glass fibres with or without benzo[a]pyrene suspended in saline, once a fortnight for 52 weeks. The experiment was terminated at week 85. 'Silicotic granulomas' consisting of tightly packed, iron-positive macrophages filled with glass fibres and surrounded by a layer of alveolar...
article 1985
(1 - 20 of 36)

Pages