(1 - 20 of 32)

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de Maat, M.P.M. (author), Knipscheer, H.C. (author), Kastelein, J.J.P. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
An elevated plasma fibrinogen level is increasingly accepted as an independent risk indicator of cardiovascular disease. This has enhanced the interest in identifying agents that can normalize elevated plasma fibrinogen levels. One group of agents with this capacity are the fibric acid derivatives, e. g. ciprofibrate and gemfibrozil. We studied...
article 1997
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Giltay, E.J. (author), Gooren, L.J.G. (author), Emeis, J.J. (author), Kooistra, T. (author), Stehouwer, C.D.A. (author), TNO Preventie en Gezondheid (author)
Oral estrogen administration decreases plasma levels of tissue-type plasminogen activator (tPA), which may be explained by a decrease in endothelial tPA synthesis, an increase in its hepatic clearance, or both. In the present study, we determined (1) differences between oral (ie, via the liver) ethinyl estradiol and transdermal (ie, systemic)...
article 2000
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Hildebrandt, V.H. (author), Proper, K.I. (author), van den Berg, R. (author), Douwes, M. (author), van den Heuvel, S.G. (author), van Buuren, S. (author), TNO Preventie en Gezondheid (author)
Objective. To determine the effectiveness of a special form of exercise therapy ('Cesar therapy') on self reported recovery and improvement of posture amongst patients with chronic aspecific lower back pain. Design. Prospective randomized controlled and blinded investigation. Method. After informed consent had been obtained, patients with...
article 2000
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Hopman-Rock, M. (author), Westhoff, M.H. (author), TNO Preventie en Gezondheid (author)
Objective. Evaluation of a self-management program for patients with osteoarthritis (OA) of the hip or knee. The program, which consisted of 6 weekly sessions of 2 hours, included health education by a peer and physical exercises taught by a physical therapist. Methods. Randomized controlled trial. Inclusion criteria were diagnosis of OA of the...
article 2000
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Chorus, A.M.J. (author), Miedema, H.S. (author), Wevers, C.W.J. (author), van der Linden, S. (author)
Objective - To assess separate and combined effects of work factors and behavioural coping in relation to withdrawal from the labour force among patients with rheumatoid arthritis (RA). Methods - A cross sectional study was conducted in a Dutch nationwide random sample of 720 patients with RA. Information about work factors and behavioural...
article 2001
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Hopman-Rock, M. (author), Westhoff, M.H. (author)
In order to promote health in people of 65 years and older, TNO Prevention and Health developed, evaluated, and implemented "Healthy & Vital" (also known as "Ageing Well and Healthily"). Healthy & Vital consists of six sessions of health education and low-intensity exercises. This paper reports on the theoretical basis of the intervention, the...
article 2002
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van den Brandt, P.A. (author), Botterweck, A.A.M. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Objective: Many case-control studies have reported that salt and cured meat intake are positively, and refrigerator use is inversely, associated with stomach cancer risk. In the current prospective study these associations were evaluated. Methods: The Netherlands Cohort Study consisted of 120,852 men and women ages 55-69 years at baseline in...
article 2003
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Reijneveld, S.A. (author), Westhoff, M.H. (author), Hopman-Rock, M. (author)
Objectives: Older immigrants from non-industrialised countries are a growing group, they have comparatively many health problems and are often hard to reach through health promotion and other preventive services. The aim of this study was to assess the effect of a short health education and physical exercise programme on the health and the...
article 2003
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Steenstra, I.A. (author), Anema, J.R. (author), Bongers, P.M. (author), de Vet, H.C.W. (author), van Mechelen, W. (author)
Background: To describe the design of a population based randomized controlled trial (RCT), including a cost-effectiveness analysis, comparing participative ergonomics interventions between 2-8 weeks of sick leave and Graded Activity after 8 weeks of sick leave with usual care, in occupational back pain management. Methods: Discussion: The...
article 2003
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TNO Arbeid (author), van den Heuvel, S.G. (author), de Looze, M.P. (author), Hildebrandt, V.H. (author), Thé, K.H. (author)
Objectives. This study evaluated the effects on work-related neck and upper-limb disorders among computer workers stimulated (by a software program) to take regular breaks and perform physical exercises. Possible effects on sick leave and productivity were studied as well. Methods. A randomized controlled design was used with cluster...
article 2003
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Agema, W.R.P. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Rabelink, T.J. (author), van Boven, A.J. (author), Feskens, E.J.M. (author), Boer, J.M.A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)
In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with...
article 2004
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de Jong, O.R.W. (author), Hopman-Rock, M. (author), Tak, E.C.M.P. (author), Klazinga, N.S. (author), TNO Preventie en Gezondheid (author)
Implementation studies are recommended to assess the feasibility and effectiveness in real-life of programmes which have been tested in randomized controlled trials (RCTs). We report on an implementation study of two evidence-based exercise and health education programmes for older adults with osteoarthritis (OA) of the knee of hip. Three types...
article 2004
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Heymans, M.W. (author), de Vet, H.C. (author), Bongers, P.M. (author), Koes, B.W. (author), van Mechelen, W. (author), TNO Arbeid (author)
To describe the design of a randomized controlled trial (RCT), including a cost-effectiveness analysis, comparing high-intensity and low-intensity back schools with usual care in occupational health care. RCT and cost-effectiveness analysis. Employees sick-listed for a period of 3 to 6 weeks because of nonspecific low back pain. High-intensity...
article 2004
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Steenstra, I.A. (author), Anema, J.R. (author), van Tulder, M.W. (author), Bongers, P.M. (author), de Vet, H.C.W. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)
Objective: To evaluate the cost-effectiveness and cost-utility of a return to work (RTW) program for workers on sick-leave due to low back pain (LBP), comparing a workplace intervention implemented between 2 to 8 weeks of sick-leave with usual care, and a clinical intervention after 8 weeks of sick-leave with usual care. Design: Economic...
article 2006
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Heymans, M.W. (author), de Vet, H.C.W. (author), Bongers, P.M. (author), Knol, D.L. (author), Koes, B.W. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)
Study Design. Randomized controlled trial. Objectives. To compare high- and low-intensity back schools with usual care in occupational health care. Summary of Background Data. The content and intensity of back schools vary widely and the methodologic quality of randomized controlled trials is generally weak. Until now, no back school has proven...
article 2006
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van der Pal, S.M. (author), Maguire, C. (author), le Cessie, S. (author), Wit, J. (author), Walther, F. (author), Bruil, J. (author), TNO Kwaliteit van Leven (author)
Aim: Developmental care has gained increased attention in the individualized care for preterm infants. This study was designed to explore the effect of a basic form of developmental care and the more extended Newborn Individualized Developmental Care and Assessment Program (NIDCAP) on parental stress, confidence and perceived nursing support....
article 2007
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Anema, J.R. (author), Steenstra, I.A. (author), Bongers, P.M. (author), de Vet, H.C.W. (author), Knol, D.L. (author), Loisel, P. (author), TNO Kwaliteit van Leven (author)
To assess the effectiveness of workplace intervention and graded activity, separately and combined, for multidisciplinary rehabilitation of low back pain (LBP). Summary of Background Data. Effective components for multidisciplinary rehabilitation of LBP are not yet established. Methods: Participants sick-listed 2 to 6 weeks due to nonspecific...
article 2007
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van Rhenen, W. (author), Blonk, R.W.B. (author), Schaufeli, W.B. (author), van Dijk, F.J.H. (author), TNO Kwaliteit van Leven (author)
Objectives: The aim of the study was to evaluate the effectiveness of two brief preventive stress reduction programs - a cognitive focused program and a combined intervention of physical exercise and relaxation - on sickness absence in stressed and non-stressed employees working in various jobs in a telecom company. Methods: The study was...
article 2007
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Bergheanu, S.C. (author), Reijmers, T. (author), Zwinderman, A.H. (author), Bobeldijk, I. (author), Ramaker, R. (author), Liem, A.-H. (author), van der Greef, J. (author), Hankemeier, T. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)
Objective: Lipid profiling (lipidomics) may be useful in revealing detailed information with regard to the effects on lipid metabolism, the cardiovascular risk and to differentiate between therapies. The aims of the present study were to: (1) analyze in depth the lipid changes induced by rosuvastatin and atorvastatin at different dosages; (2)...
article 2008
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de Vente, W. (author), Kamphuis, J.H. (author), Emmelkamp, P.M.G. (author), Blonk, R.W.B. (author), TNO Kwaliteit van Leven (author)
Work-related stress is widespread and can lead to long-term absenteeism and work disability. Cognitive-behavioral treatment (CBT) has demonstrated effectiveness in treating psychopathology but has only rarely been tested in clinical samples with work-related stress. A randomized controlled trial was conducted to investigate the efficacy of CBT...
article 2008
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