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van Verseveld, M.D.A. (author), Fekkes, M. (author), Fukkink, R.G. (author), Oostdam, R.J. (author)
This study investigates the effectiveness of the PRIMA antibullying program for elementary education using a cluster-randomized trial with two experimental conditions (with and without student lessons) and a control group. Students of 31 schools participated in the study (N = 3,135; Mage = 10 years). Multilevel regression analyses demonstrated...
article 2021
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Schoen, E.D. (author), Wopereis, S. (author)
BACKGROUND: Parallel intervention studies involving volunteers usually require a procedure to allocate the subjects to study-arms. Statistical models to evaluate the different outcomes of the study-arms will include study-arm as a factor along with any covariate that might affect the results. To ensure that the effects of the covariates are...
article 2020
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Hoevenaars, F.P.M. (author), Berendsen, C.M.M. (author), Pasman, W.J. (author), van den Broek, T.J. (author), Barrat, E. (author), de Hoogh, I.M. (author), Wopereis, S. (author)
In public health initiatives, generic nutrition advice (GNA) from national guidelines has a limited effect on food-intake improvement. Personalized nutrition advice (PNA) may enable dietary behavior change. A monocentric, randomized, parallel, controlled clinical trial was performed in males (n = 55) and females (n = 100) aged 25 to 70 years....
article 2020
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Siemonsma, P.C. (author), Blom, J.W. (author), Hofstetter, H. (author), van Hespen, A.T.H. (author), Gussekloo, J. (author), Drewes, Y.M. (author), van Meeteren, N.L.U. (author)
Background: A physically active lifestyle in older people contributes to the preservation of good health. We assessed the influence of physiotherapy on daily functioning among community dwelling older people (75+) with complex health problems identified with screening, versus usual care. We also compared functional task exercise (FTE), with...
article 2018
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Viester, L. (author), Verhagen, E.A.L.M. (author), Bongers, P.M. (author), van der Beek, A.J. (author)
Purpose: To evaluate the effectiveness of an individually tailored intervention for improvement in lifestyle behavior, health indicators, and prevention and reduction of overweight among construction workers. Design: Randomized controlled trial. Setting: Various blue-collar departments of a large construction company in the Netherlands....
article 2018
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Blanson Henkemans, O.A. (author), Keij, M. (author), Grootjen, M. (author), Kamphuis, M. (author), Dijkshoorn, A. (author)
Background: The StartingTogether program (in Dutch SamenStarten) is a family-centred method for early identification of social-emotional and behavioural problems in young children. Nurses in preventive child health care find it challenging to: determine family issues and need for care; provide education; refer to social services; increase parent...
article 2018
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de Lijster, G.P.A. (author), Felten, H. (author), Kok, G. (author), Kocken, P.L. (author)
Many adolescents experience sexual harassment and victims of sexual harassment have higher risks regarding well-being and health behaviors such as higher risks of suicidal thoughts, suicidal ideation and feeling unsafe at school. A peer-performed play and school lessons on preventing sexual harassment behavior were presented to secondary school...
article 2016
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Tsikas, D. (author), Pham, V.V. (author), Suchy, M.T. (author), van de Ree, M.A. (author), Huisman, M.V. (author), Frölich, J.C. (author), Princen, H.M.G. (author)
The present study describes the effects of atorvastatin on whole body synthesis of nitric oxide (NO), prostacyclin (PGI2), and thromboxane A2 (TxA2), on oxidative stress and nitrite/nitrate-related renal carbonic anhydrase (CA) activity in patients with type 2 diabetes mellitus (T2DM). A double-blind, randomized, placebo-controlled parallel...
article 2015
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Gerards, S.M.P.L. (author), Dagnelie, P.C. (author), Gubbels, J.S. (author), van Buuren, S. (author), Hamers, F.J.M. (author), Jansen, M.W.J. (author), van der Goot, O.H.M. (author), de Vries, N.K. (author), Sanders, M.R. (author), Kremers, S.P.J. (author)
Introduction Lifestyle Triple P is a general parenting intervention which focuses on preventing further excessive weight gain in overweight and obese children. The objective of the current study was to assess the effectiveness of the Lifestyle Triple P intervention in the Netherlands. Method We used a parallel randomized controlled design to...
article 2015
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Guigas, B. (author), de Leeuw van Weenen, J.E. (author), van Leeuwen, N. (author), Simonis-Bik, A.M. (author), van Haeften, T.W. (author), Nijpels, G. (author), Houwing-Duistermaat, J.J. (author), Beekman, M. (author), Deelen, J. (author), Havekes, L.M. (author), Penninx, B.W.J.H. (author), Vogelzangs, N. (author), van 't Riet, E. (author), Dehghan, A. (author), Hofman, A. (author), Witteman, J.C. (author), Uitterlinden, A.G. (author), Grarup, N. (author), Jørgensen, T. (author), Witte, D.R. (author), Lauritzen, T. (author), Hansen, T. (author), Pedersen, O. (author), Hottenga, J. (author), Romijn, J.A. (author), Diamant, M. (author), Kramer, M.H.H. (author), Heine, R.J. (author), Willemsen, G. (author), Dekker, J.M. (author), Eekhoff, E.M. (author), Pijl, H. (author), de Geus, E.J. (author), Slagboom, P.E. (author), 't Hart, L.M. (author)
Aims: Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic β-cells. We hypothesized that single nucleotide polymorphisms in the DRD2/ANKK1 locus may affect susceptibility to Type 2 diabetes in humans. Methods: Four potentially functional variants in the coding region of the DRD2...
article 2014
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van Wijk, R.M. (author), van Til, J.A. (author), Groothuis-Oudshoorn, C.G.M. (author), L' Hoir, M.P. (author), Boere-Boonekamp, M.M. (author), IJzerman, M.J. (author)
Purpose. Helmet therapy is regularly prescribed in infants with positional skull deformation. Evidence on the effectiveness is lacking, which complicates decision making. This study aims to assess the relation between parents’ decision for treatment of skull deformation in their infant and their level of anxiety, decisional conflict,...
article 2014
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van Genugten, G.L. (author), van Empelen, E.P. (author), Boon, B. (author), Borsboom, G. (author), Visscher, T. (author), Oenema, A. (author)
article 2013
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Bergheanu, S.C. (author), Reijmers, T. (author), Zwinderman, A.H. (author), Bobeldijk, I. (author), Ramaker, R. (author), Liem, A.-H. (author), van der Greef, J. (author), Hankemeier, T. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)
Objective: Lipid profiling (lipidomics) may be useful in revealing detailed information with regard to the effects on lipid metabolism, the cardiovascular risk and to differentiate between therapies. The aims of the present study were to: (1) analyze in depth the lipid changes induced by rosuvastatin and atorvastatin at different dosages; (2)...
article 2008
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de Vente, W. (author), Kamphuis, J.H. (author), Emmelkamp, P.M.G. (author), Blonk, R.W.B. (author), TNO Kwaliteit van Leven (author)
Work-related stress is widespread and can lead to long-term absenteeism and work disability. Cognitive-behavioral treatment (CBT) has demonstrated effectiveness in treating psychopathology but has only rarely been tested in clinical samples with work-related stress. A randomized controlled trial was conducted to investigate the efficacy of CBT...
article 2008
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van der Pal, S.M. (author), Maguire, C. (author), le Cessie, S. (author), Wit, J. (author), Walther, F. (author), Bruil, J. (author), TNO Kwaliteit van Leven (author)
Aim: Developmental care has gained increased attention in the individualized care for preterm infants. This study was designed to explore the effect of a basic form of developmental care and the more extended Newborn Individualized Developmental Care and Assessment Program (NIDCAP) on parental stress, confidence and perceived nursing support....
article 2007
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Anema, J.R. (author), Steenstra, I.A. (author), Bongers, P.M. (author), de Vet, H.C.W. (author), Knol, D.L. (author), Loisel, P. (author), TNO Kwaliteit van Leven (author)
To assess the effectiveness of workplace intervention and graded activity, separately and combined, for multidisciplinary rehabilitation of low back pain (LBP). Summary of Background Data. Effective components for multidisciplinary rehabilitation of LBP are not yet established. Methods: Participants sick-listed 2 to 6 weeks due to nonspecific...
article 2007
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van Rhenen, W. (author), Blonk, R.W.B. (author), Schaufeli, W.B. (author), van Dijk, F.J.H. (author), TNO Kwaliteit van Leven (author)
Objectives: The aim of the study was to evaluate the effectiveness of two brief preventive stress reduction programs - a cognitive focused program and a combined intervention of physical exercise and relaxation - on sickness absence in stressed and non-stressed employees working in various jobs in a telecom company. Methods: The study was...
article 2007
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Steenstra, I.A. (author), Anema, J.R. (author), van Tulder, M.W. (author), Bongers, P.M. (author), de Vet, H.C.W. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)
Objective: To evaluate the cost-effectiveness and cost-utility of a return to work (RTW) program for workers on sick-leave due to low back pain (LBP), comparing a workplace intervention implemented between 2 to 8 weeks of sick-leave with usual care, and a clinical intervention after 8 weeks of sick-leave with usual care. Design: Economic...
article 2006
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Heymans, M.W. (author), de Vet, H.C.W. (author), Bongers, P.M. (author), Knol, D.L. (author), Koes, B.W. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)
Study Design. Randomized controlled trial. Objectives. To compare high- and low-intensity back schools with usual care in occupational health care. Summary of Background Data. The content and intensity of back schools vary widely and the methodologic quality of randomized controlled trials is generally weak. Until now, no back school has proven...
article 2006
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Agema, W.R.P. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Rabelink, T.J. (author), van Boven, A.J. (author), Feskens, E.J.M. (author), Boer, J.M.A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)
In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with...
article 2004
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