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TNO Preventie en Gezondheid (author), Binkhorst, R.A. (author), Pool, J. (author), van Leeuwen, P. (author), Bouhuys, A. (author)Maximum oxygen uptake ( {Mathematical expression} max), maximum heart rate (MHR), blood lactic acid (LA) and pH were measured during bicycle ergometer exercise in 52 men, 22 to 60 years old, engaged in clerical and light manual work (prison personnel and prisoners in the Netherlands). {Mathematical expression} max decreases with, age, but less...article 1966
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Centraal Instituut voor Voedingsonderzoek TNO (author), Janbroers, J.M. (author), Sanders, J.C. (author), Til, H.P. (author), Feron, V.J. (author), de Groot, A.P. (author)Studies in rats on iocetamic acid show that the LD50 levels of this compound compare favorably with those of a number of other oral cholecystographic agents. Pathologic effects are not found in rats and cats in studies of the subacute toxicity. Incompatibility with an anesthetic or a tranquilizer is not found. The elimination pattern of...article 1969
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Germans, F.H. (author), Koster, M.W. (author), Kwee, H.H. (author), Groep Motoriek Revalidatie, Medisch Fysisch Instituut TNO Instituut voor gezondheidstechniek TNO (author)The merits of the 'vacuum form fixation' are discussed for the production of reliable body impressions of patients suffering from sitting problems. Impressions are taken with the patients seated in the desired posture. The first results are reported, obtained from 4 patients of different categories, fitted with individually moulded seats...article 1974
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- Jonkman, E.J. (author), Mosmans, P.C.M. (author) other 1977
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von Lossonczy, T.O. (author), Ruiter, A. (author), Bronsgeest-Schoute, H.C. (author), van Gent, C.M. (author), Hermus, R.J.J. (author)A cross-over study was done with 19 male and 23 female volunteers living in a monastery and a convent, respectively. The effect of a fat fish (mackerel) diet on the blood serum lipid composition was studied. As the normal diet of these volunteers was of the lacto-ovo-vegetarian type, a control diet in which the fish was replaced by full-fat...article 1978
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Gaillard, A.W.K. (author), Varey, C.A. (author), Instituut voor Zintuigfysiologie TNO (author)The effects (on human beings) of the ACTH analog Org 2766 were investigated for a range of performance tests: complicated serial reaction task, running memory span, verbal learning and non-verbal mental ability tests (closure flexibility and non-verbal abstraction). Subjective ratings on feeling were taken and heart rate was measured. Only the...article 1979
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Perdok, J. (author), Gaillard, A.W.K. (author), Instituut voor Zintuigfysiologie TNO (author)Slow EEG potentials were recorded during the foreperiod of a signal detection task which involved different levels of discrimination difficulty. The subject was requried to react to S2 as quickly as possible or to delay his responses by 1 s. It was found that the contingent negative variation (CNV) was attenuated when no speeded response was...article 1979
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Gaillard, A.W.K. (author), Perdok, J. (author), Instituut voor Zintuigfysiologie TNO (author)Slow EEG potentials (Fz, Cz, Pz) and heart rate were recorded during the foreperiod of a reaction task, which involved different levels of discrimination difficulty. A simple reaction task was compared with a selective reaction task where either an easy or a difficult discrimination was required. In general, the terminal amplitude of the CNV was...article 1979
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Gaillard, A.W.K. (author), Perdok, J. (author), Instituut voor Zintuigfysiologie TNO (author)Slow brain potentials were recorded during the foreperiod of a reaction time task, and the effects of instructions governing the trade-off between speed and accuracy were investigated. One brain potential, a slow negative shift preceding S2, was largely attenuated under accuracy instructions. It is suggested that this shift is dependent on a...article 1980
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Kluft, C. (author), Michiels, J.J. (author), Wijngaards, G. (author), Gaubius instituut TNO (author)3 patients with Behcet's disease were studied for their fibrinolytic status during exacerbation of the disease accompanied with thrombotic complications. All 3 patients exhibited low euglobulin fibrinolytic activity. This, however, could be attributed to an artificially increased coprecipitation of inhibitors, i.e., C1-inactivator in the...article 1980
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Hagenbeek, A. (author), Martens, A.C.M. (author), Radiobiologisch Instituut TNO (author)The efficacy of extracorporeal irradiation of the blood (ECIB) in combination with cell mobilization by dextran sulfate (DS; MW 17,000) was investigated in a rat model for human acute myelocytic leukemia. Repeated injections with DS (q 3 hr) induced a significant increase in the number of peripheral leukemic cells, i.e., up to 4.5 times the...article 1981
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Rijken, D.C. (author), Wijngaards, G. (author), Welbergen, J. (author), Gaubius instituut TNO (author)Human plasminogen activators were compared immunologically in both a double-diffusion technique and quenching experiments on the fibrinolytic activities of the activators. Antisera against HMW and LMW urokinase and an antiserum against highly purified tissue plasminogen activator from human uterus were used. It was found that uterine tissue...article 1981
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Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...article 1981
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Gaubius Instituut TNO (author), Havekes, L. (author), Vermeer, B.J. (author), Brugman, T. (author), Emeis, J. (author)Chemicals/CAS: Lipoprotein(a); Lipoproteins; Lipoproteins, LDL; Receptors, Cell Surface; Receptors, LDLarticle 1981
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Kluft, C. (author), Vellenga, E. (author), Brommer, E.J.P. (author), Wijngaards, G. (author), Gaubius instituut TNO (author)This study concerns a case of congenital homozygous deficiency in ??2-antiplasmin associated with a severe hemorrhagic diathesis. Heterozygous family members also show a mild bleeding tendency. The propositus is a 17-yr-old male born of white parents and showing a severe hemorrhagic diathesis characterized by spontaneous bleeding in the joints...article 1982
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Brommer, E.J.P. (author), Leuven, J.A.G. (author), Barrett-Bergshoeff, M.M. (author), Schouten, J.A. (author), Gaubius instituut TNO (author)Impairment of fibrinolysis is supposed to contribute to CVD. In 38 hyperlipoproteinemic patients, known to be at risk for early CVD, fibrinolytic activity was measured before and after stimulation with DDAVP. A negative correlation was found between serum triglyceride levels and fibrinolytic activity, both before and after DDAVP. A subnormal...article 1982
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Instituut CIVO-Toxicologie en voeding TNO (author), van Dokkum, W. (author), de Boer, B.C.J. (author), van Faassen, A. (author), Pikaar, N.A. (author), Hermus, R.J.J. (author)We suggest that a lower faecal pH may be correlated with a lower mortality of large-bowel cancer and that faecal pH should always be considered in epidemiological studies on the role of diet in colon carcinogenesis.article 1983
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de Vos, R.H. (author), van Dokkum, W. (author), Olthof, P.D.A. (author), Quirijns, J.K. (author), Muys, T. (author), van der Poll, J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Over a period of 2 yr 126 different food items of a market basket of 16-18 yr old males were purchased every 2 months. The foodstuffs were prepared as for eating, and were combined in 12 commodity groups. Twelves samples of each food group were homogenized and analysed for 78 different chemicals, including pesticides, PCBs, bromine, heavy metals...article 1984
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Vaandrager, G.J. (author), Bruining, G.J. (author), Veenhof, F.J. (author), Drayer, N.M. (author), TNO Preventie en Gezondheid (author)The incidence of childhood diabetes (0-19 years of age) in The Netherlands, where there is no nationalized health-care system, was investigated retrospectively in the years 1978 to 1980 inclusive. The method chosen was a questionnaire among all Dutch paediatricians and internal physicians acting as consultants. Ascertainment was by the same...article 1984
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Instituut CIVO-Toxicologie en Voeding TNO (author), Schrijver, J. (author), van Rijn, H.J.M. (author), Schreurs, W.H.P. (author)The reference values of the three main types of serum haptoglobin Hp 1-1, Hp 2-1, and Hp 2-2, as determined by radial immunodiffusion and with phenotype determination on polyacrylamide gel electrophoresis have been re-evaluated for both sexes. For that purpose about 500 serum samples were collected from normal, healthy Dutch volunteers. The...article 1984
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