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Schuurman, A.G. (author), Goldbohm, R.A. (author), Dorant, E. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In the Netherlands Cohort Study, the authors investigated whether anthropometry is associated with prostate cancer risk. At baseline in 1986, 58,279 men aged 55-69 years completed a self- administered questionnaire on diet, anthropometry, and other risk factors for cancer. After 6.3 years of follow-up, 681 cases were available with complete data...article 2000
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de Looze, M.P. (author), Steenhuizen, S. (author), Boeken-Kruger, M.C. (author), Baten, C.T.M. (author), Kingma, I. (author), van Dieën, J.H. (author)People who know the actual mass of an object to be lifted normally prepare themselves before attempting a lift to control the movement and to minimize low back loading. In this study, the trunk muscular reactions and low back torque were investigated in the situation in which the individual did not know the actual mass but only had some idea of...article 2000
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Tielman, M.L. (author), Neerincx, M.A. (author), van Meggelen, M. (author), Franken, I. (author), Brinkman, W.P. (author)BACKGROUND AND OBJECTIVE: With the rise of autonomous e-mental health applications, virtual agents can play a major role in improving trustworthiness, therapy outcome and adherence. In these applications, it is important that patients adhere in the sense that they perform the tasks, but also that they adhere to the specific recommendations on...article 2017
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Hosli, E. (author), Detmar, S. (author), Raat, H. (author), Bruil, J. (author), Vogels, T. (author), Verrips, E. (author), TNO Kwaliteit van Leven (author)The Child Health Questionnaire (CHQ)-87-item child and adolescent self-report (CF87) is an increasingly used health-related quality-of-life instrument for measuring the self-perceived physical and psychosocial well-being of children aged 10 years and older. The aims of this study were to evaluate structure, reliability and validity of the Dutch...article 2007
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Böhm, F.J. (author), Hirasing, R.A. (author), Vaandrager, G.J. (author), Reeser, H.M. (author), Bijlsma, F. (author), de Groot, R.M. (author), TNO Preventie en Gezondheid (author)Objective. To determine the mortality of insulin-dependent diabetes mellitus in the age group of 0-19 year over the period 1988-1990 and to compare these data with those of ten years ago. Design. Retrospective. Setting. The Netherlands. Method. The number of deaths was obtained by using the data of the death certificate registers of the Central...article 1996
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Meijer, C. (author), Timmer, A. (author), de Vries, E.G.E. (author), Groten, J.P. (author), Knol, A. (author), Zwart, N. (author), Dam, W.A. (author), Sleijfer, D.Th. (author), Mulder, N.H. (author)Cisplatin (CDDP) is an extremely active drug in the treatment of germ- cell tumours. Earlier, we found an unexpected inverse correlation between the total amount of sulfhydryl groups and CDDP sensitivity in a panel of 3 human germ-cell tumour and 3 colon-carcinoma cell lines. Major components of the sulfhydryl groups are glutathione and...article 2000
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de Jong, A.M. (author), Vink, P. (author), TNO Arbeid (author)This paper evaluates a step-by-step participatory approach to better work, applied in reducing the musculoskeletal workload in installation work. To arrive at a reduction in workload, a steering group led the project through the following steps: Introduction: defining the goal and informing all 7000 employees. Analysis: finding major loading...article 2002
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Treurniet, H.F. (author), Davidse, W. (author), TNO Preventie en Gezondheid (author)In 1983 werd door de Geneeskundige Hoofdinspectie (GHI) een landelijke registratie van seksueel overdraagbare aandoeningen (SOA's) ingevoerd, naast het registratiesysteem van wettelijk aangifteplichtige ziekten. De gegevens voor de registratie worden door sociaal-verpleegkundigen, werkzaam bij GGD'en en geslachtsziekten-poliklinieken, verzameld....article 1993
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Haverkate, F. (author), Samama, M. (author), TNO Preventie en Gezondheid (author)Approximately 250 cases of dysfibrinogenemia have been reported; 55% were asymptomatic (detected by chance), 25% had a tendency to bleeding, and 20% were reported to have a tendency to thrombosis. To establish a possible association between familial dysfibrinogenemia and thrombophilia, data on cases with both affections were collected in a study...article 1995
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Kerstholt, J.H. (author), Passenier, P.O. (author)Automation has changed the role of human operators from direct manual control to supervision. Their main task is to monitor whether system performance remains within pre-specified ranges and intervention is only required in unusual situations. One of the consequences is a loss of situation awareness, which significantly affects performance in...article 2000
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Hueber-Becker, F. (author), Nohynek, G.J. (author), Meuling, W.J.A. (author), Benech-Kieffer, F. (author), Toutain, H. (author), TNO Voeding (author)We investigated the absorption of a commercial [14C]-PPD- containing oxidative dark-shade hair dye in human volunteers as well as in vitro using human or pig ear skin. The hair of eight male volunteers was cut to a standard length, dyed, washed, dried, clipped and collected. Hair, washing water, materials used in the study and a 24-h scalp wash...article 2004
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de Lange, M. (author), de Geus, E.J.C. (author), Kluft, C. (author), Meijer, P. (author), van Doornen, L.J.P. (author), Boomsma, D.I. (author), Snieder, H. (author), TNO Kwaliteit van Leven (author)Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in...article 2006
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Botterweck, A.A.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The association between vegetable and fruit consumption and stomach cancer risk was investigated in the Netherlands Cohort Study among 120,852 men and women aged 55-69 years at the start in September 1986. Analyses were based on 282 incident stomach cancer cases after 6.3 years of follow-up. Age- and sex-adjusted rate ratios of stomach cancer in...article 1998
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van Dokkum, W. (author), Wezendonk, B. (author), Srikumar, T.S. (author), van den Heuvel, E.G.H.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To study the effect of the intake of 15 g nondigestible oligosaccharides per day on various parameters of large-bowel function, as well as on blood lipid concentrations and glucose absorption in man. Design: Latin square, randomized, double-blind, diet-controlled. Setting: Metabolic research unit. Subjects: Twelve apparently healthy...article 1999
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Lotens, W.A. (author), Wammes, L.J.A. (author)An experiment was carried out to measure the vapour resistance of two-layer clothing ensembles as a function of air permeability of the outer layer, open or closed apertures, wind, and walking, both for the total ensemble and for the outer garment alone. Six subjects walked on a treadmill (0.0, 2.5, and 5 km.h-1) which was placed in a wind...article 1993
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Albers, R. (author), van der Wielen, R.P.J. (author), Brink, E.J. (author), Hendriks, H.F.J. (author), Dorovska-Taran, V.N. (author), Mohede, I.C.M. (author), TNO Voeding (author)Objectives: To study the effects of two different mixtures of the main conjugated linoleic acid (CLA) isomers cis-9, trans-11 CLA and trans-10, cis-12 CLA on human immune function. Design: Double-blind, randomized, parallel, reference-controlled intervention study. Subjects and intervention: Seventy-one healthy males aged 31-69y received one of...article 2003
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Hooisma, J. (author), Twisk, D.A.M. (author), Platalla, S. (author), Muijser, H. (author), Kulig, B.M. (author), Medisch Biologisch Laboratorium TNO (author)The performance characteristics of 4 computerized psychological tests were studied using alcohol as a model compound. Subjects received alcohol (0.5 ml/kg) or placebo in a cross-over design and performance was assessed using the Simple Reaction Time test, the Switching Attention test, the Hand/Eye Coordination test and the Color-Word Vigilance...article 1988
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Gevers Leuven, J.A. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)Lipoprotein metabolism is involved in atherogenesis. Female sex-hormones have substantial effects on both lipoprotein metabolism and the vessel wall. Cholesterol, one of the major lipids in lipoproteins, is both the substrate for, and the target of, the steroidal sex hormones.article 1994
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Burgmeijer, R.J.F. (author), de Jonge, G.A. (author), TNO Preventie en Gezondheid (author)Objective: To determine whether the sleeping position and the use of duvets in infants in 1994 had changed in comparison with earlier years. Design: Questionnaire survey. Setting: Nationwide investigation in infant welfare centres. Method: 194 infant welfare centres participated in the investigation. In November a questionnaire was completed...article 1995
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Kluft, C. (author), Vellenga, E. (author), Brommer, E.J.P. (author), Wijngaards, G. (author), Gaubius instituut TNO (author)This study concerns a case of congenital homozygous deficiency in ??2-antiplasmin associated with a severe hemorrhagic diathesis. Heterozygous family members also show a mild bleeding tendency. The propositus is a 17-yr-old male born of white parents and showing a severe hemorrhagic diathesis characterized by spontaneous bleeding in the joints...article 1982
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