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Mevissen, F.E.F. (author), van Empelen, P. (author), Watzeels, A. (author), van Duin, G. (author), Meijer, S. (author), van Lieshout, S. (author), Kok, G. (author)
This paper describes the development of a Dutch online programme called Long Live Love+ focusing on positive, coercion-free relationships, contraception use, and the prevention of STIs, using the Intervention Mapping (IM) approach. All six steps of the approach were followed. Step 1 confirmed the need for a sexual health programme targeting...
article 2018
Klemans, R.J.B. (author), Blom, W.M. (author), van Erp, F.C. (author), Masthoff, L.J.N. (author), Rubingh, C.M. (author), van der Ent, C.K. (author), Bruijnzeel-Koomen, C.A.F.M. (author), Houben, G.F. (author), Pasmans, S.G.M.A. (author), Meijer, Y. (author), Knulst, A.C. (author)
Background: To improve food labelling strategies, information regarding eliciting doses (EDs) and the effect of patient characteristics on these EDs is necessary. Objective: To establish EDs for objective and subjective symptoms and analyse the effect of sensitization levels and other patient characteristics on threshold distribution curves ...
article 2015
Proper, K.I. (author), Koppes, L.L.J. (author), Meijer, S. (author), Bemelmans, W.J.E. (author)
OBJECTIVE: To investigate the associations between body mass index (BMI) and sick leave, and the mediating role of emotional exhaustion. METHODS: Data were collected from a large survey among Dutch employees (n = 35,022). The causal pathway approach consisting of four regression analyses was applied. RESULTS: In women, moderate overweight and...
article 2013
Jacobs, J.H. (author), Meijster, T. (author), Meijer, E. (author), Suarthana, E. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Background: Occupational airway diseases are common among bakers. The present study describes the association between exposure to wheat allergen levels and sensitization to wheat allergens, work-related upper and lower respiratory symptoms and asthma in bakery workers. Methods: As part of a Health Surveillance System for early detection of ...
article 2008
de Lange, M. (author), de Geus, E.J.C. (author), Kluft, C. (author), Meijer, P. (author), van Doornen, L.J.P. (author), Boomsma, D.I. (author), Snieder, H. (author), TNO Kwaliteit van Leven (author)
Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in...
article 2006
Hendriks, H.F.J. (author), Brink, E.J. (author), Meijer, G.W. (author), Princen, H.M.G. (author), Ntanios, F.Y. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To evaluate both efficacy and safety in humans of long-term consumption of spreads containing plant sterol esters. Design: Randomized double-blind placebo-controlled parallel trial. Subjects: Hundred and eighty-five healthy volunteers (35-64y). Intervention: Volunteers daily consumed 20g spread enriched with 1.6g plant sterols as...
article 2003
Meijer, C. (author), Timmer, A. (author), de Vries, E.G.E. (author), Groten, J.P. (author), Knol, A. (author), Zwart, N. (author), Dam, W.A. (author), Sleijfer, D.Th. (author), Mulder, N.H. (author)
Cisplatin (CDDP) is an extremely active drug in the treatment of germ- cell tumours. Earlier, we found an unexpected inverse correlation between the total amount of sulfhydryl groups and CDDP sensitivity in a panel of 3 human germ-cell tumour and 3 colon-carcinoma cell lines. Major components of the sulfhydryl groups are glutathione and...
article 2000
Rosén, S. (author), Wejkum, L. (author), Billing-Claeson, S. (author), Ghosh, R. (author), Grdic, K. (author), Chmielewska, J. (author), Meijer, P. (author), Kluft, C. (author), Tengborn, L. (author), Conkie, J. (author), Walker, I. (author), Gaubius Instituut TNO (author)
A chromogenic bioimmunoassay method for determination of t-PA activities has been evaluated on plasmas from healthy individuals and from thromboembolic patients. The assay consists of an initial binding and washing step, whereby plasma t-PA is bound to a specific monoclonal t-PA antibody, which is coated on to microplate wells, followed by a...
article 1998
Bots, M.L. (author), van der Bom, J.G. (author), Haverkate, F. (author), Meijer, P. (author), Hofman, A. (author), Grobbee, D.E. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
Background and objective. A low activated protein C (APC) response increases the risk of venous thrombosis, and possibly arterial disease. Apart from the factor V Leiden mutation, other factors may determine the level of APC response. In most studies on the association with arterial disease, cardiovascular risk factors were not appropriately...
article 1996
Meijer, W.J. (author), Verloove-Vanhorick, S.P. (author), Brand, R. (author), van den Brande, J.L. (author), TNO Preventie en Gezondheid (author)
In 563 surviving very preterm (<32 weeks gestational age) and/or very low birthweight (<1500 g) infants the relationship between neonatal thyroxine concentration and psychomotor development at 2 years of age (corrected for preterm birth) was studied. A significant association was found between low neonatal thyroxine concentration and a negative...
article 1992
Kwekkeboom, J. (author), Princen, H.M.G. (author), van Voorthuizen, E.M. (author), Meijer, P. (author), Kempen, H.J.M. (author), Gaubius Instituut TNO (author)
Intracellular accumulation of 37°C of 50 μM [14C]taurocholic acid by hepatocytes of pig and rat, cultured for 24 hours, and by human hepatocytes, cultured for 12 hours, reached equilibrium after an incubation time of 1 to 2 hours. Maximum capacity to accumulate taurocholate intracellularly was assessed in 3-hour incubations with increasing...
article 1989
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