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Liang, W. (author), Menke, A.L. (author), Driessen, A. (author), Koek, G.H. (author), Lindeman, J.H. (author), Stoop, R. (author), Havekes, L.M. (author), Kleemann, R. (author), van den Hoek, A.M. (author)
Results: The criteria macrovesicular steatosis, microvesicular steatosis, hepatocellular hypertrophy, inflammation and fibrosis were generally applicable to rodent NAFLD. The inter-observer reproducibility (evaluated using the Intraclass Correlation Coefficient) between the ten observers was high for the analysis of macrovesicular steatosis and...
article 2014
document
Mooijaart, S.P. (author), Berbée, J.F.P. (author), van Heemst, D. (author), Havekes, L.M. (author), de Craen, A.J.M. (author), Slagboom, P.E. (author), Rensen, P.C.N. (author), Westendorp, R.G.J. (author), TNO Kwaliteit van Leven (author)
Background: The ε2, ε3, and ε4 alleles of the apolipoprotein E gene (APOE) encode three isoforms, apoE2, E3, and E4, respectively. The apoE isoforms circulate in different plasma concentrations, but plasma concentrations of the same isoform also differ between individuals. Whereas the isoforms have been associated with cardiovascular disease,...
article 2006
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Wang, M. (author), Lamers, R.J.A.N. (author), Korthout, H.A.A.J. (author), van Nesselrooij, J.H.J. (author), Witkamp, R.F. (author), van der Heijden, R. (author), Voshol, P.J. (author), Havekes, L.M. (author), Verpoorte, R. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
The introduction of the concept of systems biology, enabling the study of living systems from a holistic perspective based on the profiling of a multitude of biochemical components, opens up a unique and novel opportunity to reinvestigate natural products. In the study of their bioactivity, the necessary reductionistic approach on single active...
article 2005
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Boer, J.M.A. (author), Ehnholm, C. (author), Menzel, H.J. (author), Havekes, L.M. (author), Rosseneu, M. (author), O'Reilly, D.S.J. (author), Tiret, L. (author), Gaubius Instituut TNO (author)
To elucidate how the apolipoprotein (apo)E polymorphism and modifiable factors interact in explaining plasma lipid and apolipoprotein levels, we studied 1448 young adults (18 to 26 years old), participating in the European Atherosclerosis Research Study (EARS). Venous blood was collected after an overnight fast. Modifiable factors, eg, body mass...
article 1997
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Feskens, E.J.M. (author), Havekes, L.M. (author), Kalmijn, S. (author), de Knijff, P. (author), Launer, L.J. (author), Kromhout, D. (author), TNO Preventie en Gezondheid (author)
Objectives - To determine whether polymorphism of apolipoprotein E - notably, the e4 allele - predicts cognitive deterioration in the general population. Design - Population based cohort investigated in 1990 and in 1993. Setting - Zutphen, the Netherlands. Subjects - Representative cohort of 538 Dutch men aged 70-89 at baseline. Main outcome...
article 1994
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de Knijff, P. (author), van den Maagdenberg, A.M.J.M. (author), Frants, R.R. (author), Havekes, L.M. (author), TNO Preventie en Gezondheid (author)
Apolipoprotein E (apoE) is one of the major protein constituents of chylomicron and very-low-density lipoprotein (VLDL) remnants and plays a central role as a ligand in the receptor-mediated uptake of these particles by the liver. Including the most common variant, apoE3, 30 apoE variants have been characterized. At present, 14 apoE variants...
article 1994
document
de Knijff, P. (author), van den Maagdenberg, A.M.J.M. (author), Stalenhoef, A.F.H. (author), Leuven, J.A.G. (author), Demacker, P.N.M. (author), Kuyt, L.P. (author), Frants, R.R. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
By the careful screening of familial dysbetalipoproteinemic (FD) patients, five probands showing heterozygosity for the APOE*3-Leiden allele were found. Genealogical studies revealed that these probands share common ancestry in the 17th century. In a group of 128 family members, spanning three generations, 37 additional heterozygous APOE*3...
article 1991
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de Knijff, P. (author), Rosseneu, M. (author), Beisiegel, U. (author), de Keersgieter, W. (author), Frants, R.R. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Recently, we determined the apolipoprotein E (apoE) phenotype distribution in 2,000 randomly selected 35-year-old male individuals by slab gel isoelectric focusing of delipidated plasma samples, followed by immunoblotting using anti-apoE antiserum. These blots have been successfully re-used for immunovisualization of apoA-IV isoelectric focusing...
article 1988
document
Havekes, L. (author), Vermeer, B.J. (author), Brugman, T. (author), Emeis, J. (author), Gaubius Instituut TNO (author)
Chemicals/CAS: Lipoprotein(a); Lipoproteins; Lipoproteins, LDL; Receptors, Cell Surface; Receptors, LDL
article 1981
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