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Maasland, D.H.E. (author), van den Brandt, P.A. (author), Kremer, B. (author), Goldbohm, R.A. (author), Schouten, L.J. (author)
There is limited prospective data on the relationship between consumption of vegetables and fruits and the risk of head-neck cancer (HNC) subtypes [i.e., oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC) and laryngeal cancer (LC)]. Therefore, we investigated these associations within the Netherlands Cohort Study, in which 120,852...
article 2015
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Offermans, N.S.M. (author), Vermeulen, R. (author), Burdorf, A. (author), Goldbohm, R.A. (author), Keszei, A.P. (author), Peters, S. (author), Kauppinen, T. (author), Kromhout, H. (author), van den Brandt, P.A. (author)
The evidence for an association between occupational asbestos exposure and esophageal, gastric and colorectal cancer is limited. We studied this association specifically addressing risk differences between relatively low and high exposure, risk associated with cancer subtypes, the influence of potential confounders and the interaction between...
article 2014
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Offermans, N.S.M. (author), Vermeulen, R. (author), Burdorf, A. (author), Goldbohm, R.A. (author), Keszei, A.P. (author), Peters, S. (author), Kauppinen, T. (author), Kromhout, H. (author), van den Brandt, P.A. (author)
Objectives The evidence for an association between occupational asbestos exposure and pharyngeal cancer (PhC) is limited, while for oral cavity cancer (OCC) the literature is even sparser. We studied OCC and PhC risk both separately and combined (OCPC) in relation to occupational asbestos exposure, specifically addressing the influence of...
article 2014
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Genkinger, J.M. (author), Wang, M. (author), Li, R. (author), Albanes, D. (author), Anderson, K.E. (author), Bernstein, L. (author), van den Brandt, P.A. (author), English, D.R. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Gapstur, S.M. (author), Giles, G.G. (author), Goldbohm, R.A. (author), Håkansson, N. (author), Horn-Ross, P.L. (author), Koushik, A. (author), Marshal, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Robien, K. (author), Rohan, T.E. (author), Schairer, C. (author), Silverman, D.T. (author), Stolzenberg-Solomon, R.Z. (author), Virtamo, J. (author), Willett, W.C. (author), Wolk, A. (author), Ziegler, R.G. (author), Smith-Warner, S.A. (author)
Pancreatic cancer has few early symptoms, is usually diagnosed at late stages, and has a high case-fatality rate. Identifying modifiable risk factors is crucial to reducing pancreatic cancer morbidity and mortality. Prior studies have suggested that specific foods and nutrients, such as dairy products and constituents, may play a role in...
article 2014
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Maasland, D.H.E. (author), van den Brandt, P.A. (author), Kremer, S.H.A. (author), Goldbohm, R.A. (author), Schouten, L.J. (author)
Background: Prospective data on alcohol consumption, cigarette smoking and risk of head-neck cancer (HNC) subtypes, i.e. oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), are limited. We investigated these associations within the second largest prospective study on this topic so far, the Netherlands Cohort...
article 2014
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Koeman, T. (author), Slottje, P. (author), Kromhout, H. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Vermeulen, R. (author)
Objectives Although a study among utility workers found an increased risk for acute myocardial infarction and arrhythmia-related deaths associated with occupational extremely low-frequency magnetic fields (ELF-MF) exposure, later studies largely failed to replicate these findings. This study investigated the association between occupational ELF...
article 2013
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Zeegers, M.P. (author), Nekeman, D. (author), Khan, H.S. (author), van Dijk, B.A.C. (author), Goldbohm, R.A. (author), Schalken, J. (author), Shajahan, S. (author), Pearlman, A. (author), Oddoux, C. (author), van den Brandt, P.A. (author), Schouten, L.J. (author), Ostrer, H. (author), TNO Preventie en Gezondheid (author)
Background:Prostate cancer is the most commonly diagnosed cancer in men in Europe and the United States. Numerous studies have indicated genetics to have a major role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have detected an association between prostate...
article 2013
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Geybels, M.S. (author), Verhage, B.A.J. (author), van Schooten, F.J. (author), Goldbohm, A. (author), van den Brandt, P.A. (author)
BACKGROUND: Selenium may prevent advanced prostate cancer (PCa), but most studies on this topic were conducted in populations with moderate to high selenium status. We investigated the association of toenail selenium, reflecting long-term selenium exposure, and advanced PCa risk in a population from the Netherlands where low selenium status is...
article 2013
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Cho, E. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Colditz, G.A. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Pietinen, P. (author), Potter, J.D. (author), Rohan, T.E. (author), Terry, P. (author), Toniolo, P. (author), Virtanen, M.J. (author), Willet, W.C. (author), Wolk, A. (author), Wu, K. (author), Yaun, S.-S. (author), Zeleniuch-Jacquotte, A. (author), Hunter, D.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Studies in animals have suggested that calcium may reduce the risk of colorectal cancer. However, results from epidemiologic studies of intake of calcium or dairy foods and colorectal cancer risk have been inconclusive. Methods: We pooled the primary data from 10 cohort studies in five countries that assessed usual dietary intake by...
article 2004
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Männistö, S. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Albanes, D. (author), Anderson, K. (author), van den Brandt, P.A. (author), Cerhan, J.R. (author), Colditz, G. (author), Feskanich, D. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Rohan, T.E. (author), Virtamo, J. (author), Willett, W.C. (author), Hunter, D.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Intervention trials with supplemental β-carotene have observed either no effect or a harmful effect on lung cancer risk. Because food composition databases for specific carotenoids have only become available recently, epidemiological evidence relating usual dietary levels of these carotenoids with lung cancer risk is limited. We analyzed the...
article 2004
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Lüchtenborg, M. (author), Weijenberg, M.P. (author), Roemen, G.M.J.M. (author), de Bruïne, A.P. (author), van den Brandt, P.A. (author), Lentjes, M.H.F.M. (author), Brink, M. (author), van Engeland, M. (author), Goldbohm, R.A. (author), de Goeij, A.F.P.M. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The adenomatous polyposis coli (APC) gene is considered to be a gatekeeper in colorectal tumourigenesis. Inactivating mutations in APC have been reported in 34-70% of sporadic colorectal cancer patients, the majority of which occur in the mutation cluster region (MCR). In this study, tumour tissue from 665 incident colorectal cancer patients,...
article 2004
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Schuurman, A.G. (author), Goldbohm, R.A. (author), Dorant, E. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In the Netherlands Cohort Study, the authors investigated whether anthropometry is associated with prostate cancer risk. At baseline in 1986, 58,279 men aged 55-69 years completed a self- administered questionnaire on diet, anthropometry, and other risk factors for cancer. After 6.3 years of follow-up, 681 cases were available with complete data...
article 2000
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Goldbohm, R.A. (author), Voorrips, L.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 2000
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Botterweck, A.A.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
BACKGROUND. Numerous components of fruit and vegetables are considered to decrease the risk of gastric carcinoma. In the current prospective study, the authors examined the association between the intake of vitamins, carotenoids, and dietary fiber and vitamin supplement use and the incidence rate of gastric carcinoma. METHODS. The Netherlands...
article 2000
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Botterweck, A.A.M. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Kleinjans, J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Both carcinogenic and anticarcinogenic properties have been reported for the synthetic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The association between dietary intake of BHA and BHT and stomach cancer risk was investigated in the Netherlands Cohort Study (NLCS) that started in 1986 among 120,852 men and...
article 2000
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Voorrips, L.E. (author), Goldbohm, R.A. (author), van Poppel, G. (author), Sturmans, F. (author), Hermus, R.J.J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The relation between vegetable and fruit consumption and colorectal cancer risk was comprehensively assessed in the Netherlands Cohort Study on Diet and Cancer using a validated 150-item food frequency questionnaire. After 6.3 years of follow-up (1986-1992), over 1,000 incident cases of colorectal cancer were registered. Using case-cohort...
article 2000
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Kampman, E. (author), Voskuil, D.W. (author), van Kraats, A.A. (author), Balder, H.F. (author), van Muijen, G.N.P. (author), Goldbohm, R.A. (author), van 't Veer, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
K-ras gene mutations (codons 12 and 13) were determined by PCR-based mutant allele-specific amplification (MASA) in tumour tissue of 185 colon cancer patients: 36% harboured mutations, of which 82% were located in codon 12. High intakes of animal protein, calcium and poultry were differently associated with codon 12 and 13 mutations: odds ratios...
article 2000
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Voskuil, D.W. (author), Kampman, E. (author), van Kraats, A.A. (author), Balder, H.F. (author), van Muijen, G.N.P. (author), Goldbohm, R.A. (author), van 't Veer, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Epidemiological studies have suggested that dietary factors may differently affect p53-dependent and p53-independent pathways to colon cancer. Results of such studies may depend on the method used to assess p53 status. This case-control study of 185 colon-cancer cases and 259 controls examines this relation, using both immunohistochemistry and...
article 1999
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Schuurman, A.G. (author), Zeegers, M.P.A. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
We investigated the risk of prostate cancer in relation to a family history of prostate cancer in 58,279 men ages 55-69 years. We found 704 incident cases after 6.3 years of follow-up. Rate ratios and 95% confidence intervals for having an affected vs nonaffected father and brother were, respectively 1.44 (0.80-2.58) and 5.57 (1.61-19.26). We...
article 1999
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Schuurman, A.G. (author), van den Brandt, P.A. (author), Dorant, E. (author), Brants, H.A.M. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
BACKGROUND. The roles of energy and fat intake as risk factors for prostate carcinoma are still questionable. Therefore, these factors were evaluated in the Netherlands Cohort Study described in this article.
article 1999
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