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van den Berg, H. (author), Louwerse, E.S. (author), Bruinse, H.W. (author), Thissen, J.T.N.M. (author), Schrijver, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The vitamin B6 status of women suffering from premenstrual symptoms (PMS, n = 19) and a group of matched controls (n = 19) has been investigated. The women volunteering in the study were selected on strictly defined criteria. Several biochemical parameters of the metabolism of vitamin B6 and tryptophan were studied in blood and urine samples...
article 1986
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Emeis, J.J. (author), van Houwelingen, A.C. (author), van den Hoogen, C.M. (author), Hornstra, G. (author), Gaubius Institute TNO, 2300 AP Leiden, Netherlands (author)
For a period of 6 weeks, 76 healthy male volunteers consumed during their daily main meal the contents of one tin (~ 135 g) of either fish (mackerel) paste or meat paste. Fibrinolytic parameters were determined in plasma samples obtained at the beginning and at the end of the experimental period. No changes were found in plasminogen, α2...
article 1989
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Wertheim, A.H. (author), van Gelder, P. (author)
When the eyes pursue a fixation point that sweeps across a moving background pattern, and the fixation point is suddenly made to stop, the ongoing motion of the background pattern seems to accelerate to a higher velocity. Experiment I showed that this acceleration illusion is not caused by the sudden change in (i) the relative velocity between...
article 1990
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van 't Veer, P. (author), van Leer, E.M. (author), Rietdijk, A. (author), Kok, F.J. (author), Schouten, E.G. (author), Hermus, R.J.J. (author), Sturmans, F. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Combinations of dietary factors were studied in relation to breast-cancer occurrence among 133 breast cancer cases and 289 population controls in The Netherlands. Dietary factors were classified according to their possible mechanism of action, i.e., relating either to the intestinal microflora (total fat, fiber, fermented milk products) or to...
article 1991
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Leenheers, L.H. (author), van Breugel, D.C. (author), Ravensberg, J.C. (author), Meuling, W.J.A. (author), Jongen, M.J.M. (author), Medisch Biologisch Laboratorium TNO (author)
An analytical method for the assessment of the exposure of workers to the pesticide propoxur through biological monitoring has been developed. This study was part of a survey of occupational exposure to pesticides used in greenhouses for the growing of ornamental plants. In order to assess the actual absorbed amount of propoxur in the body, an...
article 1992
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van de Water, H.P.A. (author), Bijleveld, C.C.J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
Eind 1990 verschenen in dit tijdschrift twee artikelen over het aantal met HIV geïnfecteerden in Nederland. Hieruit bleek dat het aantal HIV-seropositieven lager lag dan eerder werd aangenomen, maar dat desondanks een stijgend aantal AIDS-patiënten verwacht mocht worden. In uitkomsten liepen de twee onderzoeken niet ver uiteen. Jager et al....
article 1992
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Treurniet, H.F. (author), Davidse, W. (author), TNO Preventie en Gezondheid (author)
In 1983 werd door de Geneeskundige Hoofdinspectie (GHI) een landelijke registratie van seksueel overdraagbare aandoeningen (SOA's) ingevoerd, naast het registratiesysteem van wettelijk aangifteplichtige ziekten. De gegevens voor de registratie worden door sociaal-verpleegkundigen, werkzaam bij GGD'en en geslachtsziekten-poliklinieken, verzameld....
article 1993
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Verkerk, P.H. (author), Derksen-Lubsen, G. (author), Vulsma, T. (author), Loeber, J.G. (author), de Vijlder, J.J.M. (author), Verbrugge, H.P. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
Doel. Evaluatie van de Nederlandse screening op congenitale hypothyreoïdie (CHT). Opzet. Descriptief. Plaats. Landelijk. Methoden. Gegevens over de screening in de periode 1 januari 1981-31 december 1990 werden verkregen van de entadministraties, van laboratoria en van kinderartsen naar wie kinderen met afwijkende uitslagen verwezen werden....
article 1993
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Buitendijk, S.E. (author), van Enk, A. (author), Oosterhout, R. (author), Ris, M. (author), TNO Preventie en Gezondheid (author)
The objective was to compare the course of teenage pregnancies and deliveries with those of women between the ages of 20 and 29, using data from the 1989 National Obstetric Database (LVR) when approximately 76% of cases conducted by obstetricians were registered. 4500 teenage pregnancies were studied to compare the risk of preterm birth, low...
article 1993
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Einerhand, M.P.W. (author), Bakx, T.A. (author), Kukler, A. (author), Valerio, D. (author), Radiobiologisch Instituut TNO (author)
An amphotropic retroviral vector, LgAL(ΔMo + PyF101) containing a human adenosine deaminase (ADA) cDNA was used to optimize procedures for the lasting genetic modification of the hematopoietic system of mice. The highest number of retrovirally infected cells in the hematopoietic tissues of long- term reconstituted mice was observed after...
article 1993
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Walraven, J. (author), Janzen, P. (author)
In this investigation, carried out under a Youth Health Care postgraduate course in Nijmegen, the stereopsis of a school population of 730 children, aged 4-18 years, was recorded and clinically evaluated. Stereopsis was measured using the TNO test, a random-dot stereo test especially designed for the early detection of amblyopia. The main aims...
article 1993
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Hirasing, R.A. (author), Schaapveld, K. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
article 1993
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Vink, A.A. (author), Bergen Henegouwen, J.B.A. (author), Nikaido, O. (author), Baan, R.A. (author), Roza, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Induction and removal of cyclobutane thymine dimers and (6-4)photoproducts were studied in epidermal DNA isolated from UV-exposed hairless mice. For the detection of DNA damage, lesion-specific monoclonal antibodies were used in an immunoslotblot assay. Following the exposure of mice to 3.0 kJ m-2 UV-B, substantial removal of both thymine dimers...
article 1994
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Reerink, J.D. (author), Herngreen, W.P. (author), Peters, A.C.B. (author), den Ouden, A.L. (author), Verloove-Vanhorick, S.P. (author), Ruys, J.H. (author), TNO Preventie en Gezondheid (author)
Objective. Assessment of the prevalence of convulsion-like symptoms in 1854 children of Dutch-speaking mothers of a population-based birth cohort. Method. At each child health clinic (CHC) visit mothers were asked whether they had noted any of the following signs: loss of consciousness, involuntary movements, eye rotation movements and apnoea,...
article 1994
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Verkerk, P.H. (author), van Spronsen, F.J. (author), Smit, G.P.A. (author), Sengers, R.C.A. (author)
Objective - To assess whether physical growth is affected in early treated Dutch patients with phenylketonuria (PKU). Methods - The birth weights of all 137 early detected patients with PKU born in the period from 1974 to 1988 in the Netherlands were compared with reference values. Height, head circumference, and weight were measured at the age...
article 1994
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Vink, P. (author), Douwes, M. (author), van Woensel, W. (author)
The effects of a portable back support, the Back-Up, were tested in 28 variables. Both subjective and objective physical load measures were recorded during sitting with and without Back-Up, most of them during VDU work. The main result was that the posture of the upper back and neck/head was improved by the Back-Up. However, the knee straps...
article 1994
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Schrauwen, Y. (author), Emeis, J.J. (author), Kooistra, T. (author), TNO Preventie en Gezondheid (author)
The development of a highly sensitive, enzyme-linked immunosorbent assay (ELISA) for tissue-type plasminogen activator (tPA) is described. The use of a biotin-avidin system resulted in a detection limit of 10 pg of tPA per ml, which is 50 to 150 times more sensitive than commercially-available ELISAs. Free tPA and tPA complexed to PA inhibitor...
article 1994
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Bos, R. (author), Revet, M. (author), Nieuwenhuizen, W. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
This article describes a two-step bio-immuno assay (BIA), which determines active (free) tissue-type plasminogen activator (t-PA) in (acidified) plasma. Plasma samples, diluted in buffer of pH 6.0, are added to the wells of a microtiter plate containing an immobilised monoclonal antibody which binds t-PA without affecting t-PA activity. After an...
article 1994
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Verkerk, P.H. (author), Buitendijk, S.E. (author), Verloove-Vanhorick, S.P. (author)
Background. The validity of the results of studies using retrospectively collected information on exposures is often criticized, because cases may report differently from controls even if their true exposure status is the same. This study was performed to quantify the extent to which this effect (differential misclassification) may occur for...
article 1994
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Verkerk, P.H. (author), Zaadstra, B.M. (author), Reerink, J.D. (author), Herngreen, W.P. (author), Verloove-Vanhorick, S.P. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
Social class and ethnicity are important risk factors for small-for-gestational-age and preterm delivery in many countries. This study was performed to assess whether this is also the case in the Netherlands, a country with a high level of social security, relatively small income differences and easy access to medical care for all its...
article 1994
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