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Zwaveling-Soonawala, N. (author), Trotsenburg, A.S. (author), Verkerk, P.H. (author)
Context. In central hypothyroidism (CeH) free thyroxine (FT4) concentrations are low while TSH concentrations may be low, normal or even slightly elevated due to reduced bioactivity. Congenital CeH (CCeH) may be isolated or part of multiple pituitary hormone deficiency (MPHD). Objective. To test our hypotheses that (1) TSH concentrations have a...
article 2018
Stemerdink, N.B.A. (author), van der Molen, M.W. (author), Kalverboer, A.F. (author), van der Meere, J.J. (author), Huisman, J. (author), de Jong, L.W. (author), Slijper, F.M.E. (author), Verkerk, P.H. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)
In this study, we tested the hypothesis that patients with early and continuously treated phenylketonuria (PKU) are selectively impaired in cognitive functions dependent on the prefrontal cortex (PFC) over a wide age range. Thirty-six patients with PKU between 8 and 20 years of age and 36 controls matched for age, sex, and educational level of...
article 1999
Verkerk, P.H. (author), van Spronsen, F.J. (author), Smit, G.P.A. (author), Sengers, R.C.A. (author)
Objective - To assess whether physical growth is affected in early treated Dutch patients with phenylketonuria (PKU). Methods - The birth weights of all 137 early detected patients with PKU born in the period from 1974 to 1988 in the Netherlands were compared with reference values. Height, head circumference, and weight were measured at the age...
article 1994