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Anjema, K. (author), van Rijn, M. (author), Verkerk, P.H. (author), Burgerhof, J.G.M. (author), Heiner-Fokkema, M.R. (author), van Spronsen, F.J. (author)
In phenylketonuria, knowledge about the relation between behavior and plasma phenylalanine is scarce. The aim of this study was to determine whether high phenylalanine is associated with disturbed behavior noticed by the patient and or close environment (parents or partners). 48 early treated PKU patients (median age 8.5, range 0-35. years)...
article 2011
document
van Spronsen, F.J. (author), Rijn, M. (author), Dorgelo, B. (author), Hoeksma, M. (author), Bosch, A.M. (author), Mulder, M.F. (author), de Klerk, J.B.C. (author), de Koning, T. (author), Rubio-Gozalbo, M.E. (author), de Vries, M. (author), Verkerk, P.H. (author)
Background: The clinical severity of phenylalanine hydroxylase deficiency is usually defined by either pre-treatment phenylalanine (Phe) concentration or Phe tolerance at 5 years of age. So far, little is known about the course of Phe tolerance or the ability of both pre-treatment Phe and Phe tolerance at early age to predict Phe tolerance at...
article 2009
document
Stemerdink, N.B.A. (author), van der Molen, M.W. (author), Kalverboer, A.F. (author), van der Meere, J.J. (author), Huisman, J. (author), de Jong, L.W. (author), Slijper, F.M.E. (author), Verkerk, P.H. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)
In this study, we tested the hypothesis that patients with early and continuously treated phenylketonuria (PKU) are selectively impaired in cognitive functions dependent on the prefrontal cortex (PFC) over a wide age range. Thirty-six patients with PKU between 8 and 20 years of age and 36 controls matched for age, sex, and educational level of...
article 1999
document
Verkerk, P.H. (author), van Spronsen, F.J. (author), Smit, G.P.A. (author), Sengers, R.C.A. (author)
Objective - To assess whether physical growth is affected in early treated Dutch patients with phenylketonuria (PKU). Methods - The birth weights of all 137 early detected patients with PKU born in the period from 1974 to 1988 in the Netherlands were compared with reference values. Height, head circumference, and weight were measured at the age...
article 1994
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