(1 - 20 of 65)

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Rose, D.J. (author), Venema, K. (author), Keshavarzian, A. (author), Hamaker, B.R. (author), TNO Kwaliteit van Leven (author), KvL (author)
article 2010
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Venema, K. (author), TNO Kwaliteit van Leven (author)
article 2010
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Mateo Anson, N. (author), Havenaar, R. (author), Vaes, W. (author), Coulier, L. (author), Venema, K. (author), Selinheimo, E. (author), Bast, A. (author), Haenen, G.R.M.M. (author)
The health benefits of whole grain consumption can be partly attributed to the inclusion of the bran or outer-layers of the grain rich in dietary fibre. Fibre is fermented in the colon, leading to the production of beneficial metabolites, such as short-chain fatty acids (SCFA). The effect of five different types of bread on the SCFA production...
article 2011
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Zhu, Y. (author), Havenaar, R. (author), Venema, K. (author)
article 2011
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Venema, K. (author)
article 2011
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Martinez, R.C.R. (author), Aynaou, A.E. (author), Albrecht, S. (author), Schols, H.A. (author), de Martinis, E.C.P. (author), Zoetendal, E.G. (author), Venema, K. (author), Saad, S.M.I. (author), Smidt, H. (author)
Probiotic properties of Lactobacillus amylovorus DSM 16698 were previously demonstrated in piglets. Here, its potential as a human probiotic was studied in vitro, using the TIM-1 system, which is fully validated to simulate the human upper gastrointestinal tract. To evaluate the effect of the food matrix composition on the survival of L....
article 2011
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Rehman, A. (author), Heinsen, F.A. (author), Koenen, M.E. (author), Venema, K. (author), Knecht, H. (author), Hellmig, S. (author), Schreiber, S. (author), de Ott, S.J. (author)
Background: Antibiotic associated diarrhea and Clostridium difficile infection are frequent complications of broad spectrum antibiotic therapy. Probiotic bacteria are used as therapeutic and preventive agents in these disorders, but the exact functional mechanisms and the mode of action are poorly understood. The effects of clindamycin and the...
article 2012
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Roeselers, G. (author), Bouwman, J. (author), Venema, K. (author), Montijn, R. (author)
The mammalian gastrointestinal tract (GIT) harbors microorganisms (the microbiota) of vast phylogentic, genomic, and metabolic diversity, and recent years have seen a rapid development in the techniques for studying these complex microbial ecosystems. It is increasingly apparent that the GIT microbiota plays an intricate role in host health and...
article 2012
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Al-Lahham, S. (author), Roelofsen, H. (author), Rezaee, F. (author), Weening, D. (author), Hoek, A. (author), Vonk, R. (author), Venema, K. (author)
Background Adipose tissue is a primary site of obesity-induced inflammation, which is emerging as an important contributor to obesity-related diseases such as type 2 diabetes. Dietary fibre consumption appears to be protective. Short-chain fatty acids, e.g. propionic acid, are the principal products of the colonic fermentation of dietary fibre...
article 2012
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Maathuis, A.J.H. (author), van den Heuvel, E.G. (author), Schoterman, M.H.C. (author), Venema, K. (author)
Galacto-oligosaccharides (GOS) are considered to be prebiotic, although the contribution of specific members of the microbiota to GOS fermentation and the exact microbial metabolites that are produced upon GOS fermentation are largely unknown. We aimed to determine this using uniformly 13C-labeled GOS. The normal (control) medium and unlabeled...
article 2012
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Hatanaka, M. (author), Nakamura, Y. (author), Maathuis, A.J.H. (author), Venema, K. (author), Murota, I. (author), Yamamoto, N. (author)
Survival and germination rate of Bacillus subtilis C-3102 spores were investigated in a stomach and small intestine model (TIM-1), while the impact of C-3102 cells that had passed through TIM-1 on human colon microbiota was evaluated in a model of the large intestine (TIM-2). The survival of C-3102 spores in TIM-1 was 99%; 8% of the spores had...
article 2012
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Meijerink, M. (author), Wells, J. (author), Taverne, N. (author), de Zeeuw Brouwer, M.L. (author), Hilhorst, B. (author), Venema, K. (author), van Bilsen, J. (author)
Peanut allergy accounts for the majority of severe food-related allergic reactions and there is a need for new prevention and treatment strategies. Probiotics may be considered for treatment on the basis of their immunomodulating properties. Cytokine profiles of probiotic strains were determined by in vitro co-culture with human PBMCs. Three...
article 2012
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Vanhoutvin, S.A. (author), Troost, F.J. (author), Kilkens, T.O. (author), Lindsey, P.J. (author), Jonkers, D.M. (author), Venema, K. (author), Masclee, A. (author), Brummer, R.J. (author)
BACKGROUND: Barostat methodology is widely used for assessing visceral perception. Different barostat protocols are described with respect to the measurement of rectal compliance and visceral perception. The choice of protocols affects the duration, which is normally 60-90 min, and accuracy of the procedure. This study aimed to shorten the...
article 2012
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Makivuokko, H. (author), Wacklin, P. (author), Koenen, M.E. (author), Laamanen, K. (author), Alakulppi, N. (author), Venema, K. (author), Matto, J. (author)
Background: Currently, there is a constant need to find microbial products for maintaining or even improving host microbiota balance that could be targeted to a selected consumer group. Blood group secretor status, determining the ABO status, could be used to stratify the consumer group. Objective: We have applied a validated upper intestinal...
article 2012
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Venema, K. (author)
This review describes the recent advances in technology to study fermentation of lactose and its prebiotic derivatives, including human milk oligosaccharides. Novel molecular tools to identify members of the microbiota that ferment these substrates are highlighted, as well as the use of stable isotope-labelled substrates to be able to trace...
article 2012
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Venema, K. (author)
article 2012
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Martinez, R.C.R. (author), Cardarelli, H.R. (author), Borst, W. (author), Albrecht, S. (author), Schols, H. (author), GutiƩrrez, O.P. (author), Maathuis, A.J.H. (author), de Melo Franco, B.D.G. (author), de Martinis, E.C.P. (author), Zoetendal, E.G. (author), Venema, K. (author), Saad, S.M.I. (author), Smidt, H. (author)
A validated in vitro model of the large intestine (TIM-2), set up with human or pig faeces, was used to evaluate the impact of potentially probiotic Lactobacillus amylovorus DSM 16698, administered alone (i), in the presence of prebiotic galactooligosaccharides (GOS) (ii), and co-administered with probiotic Bifidobacterium animalis ssp. lactis...
article 2013
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Blatchford, P. (author), Ansell, J. (author), de Godoy, M.R.C. (author), Fahey, G. (author), Garcia-Mazcorro, J.F. (author), Gibson, G.R. (author), Goh, Y.J. (author), Hotchkiss, A.T. (author), Hutkins, R. (author), LaCroix, C. (author), Rastall, R.A. (author), Reimer, R.A. (author), Schoterman, M. (author), Van Sinderen, D. (author), Venema, K. (author), Whelan, K. (author)
In October 2012, a group of scientists met at the 10th Meeting of the International Scientific Association of Probiotics and Prebiotics (ISAPP) in Cork, Ireland to discuss issues surrounding prebiotics and their development. This article summarises outputs from the meeting. Various prebiotic definitions were discussed and how the concept has...
article 2013
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van den Abbeele, P. (author), Venema, K. (author), van de Wiele, T. (author), Verstraete, W. (author), Possemiers, S. (author)
Different in vitro models have been developed to assess how food compounds affect the human gut microbiota. Using two such models (SHIME(R) and TIM-2), we compared how long-chain arabinoxylan (LC-AX), a wheat-derived potentially prebiotic fiber, and inulin (IN), a well-established prebiotic compound, modulate SCFA production and bifidobacteria...
article 2013
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Venema, K. (author), van den Abbeele, P. (author)
The human gut contains a diverse microbiota with large potential to influence health. Given the difficulty to access the main sites of the gut, in vitro models have been developed to dynamically monitor microbial processes at the site of metabolic activity. These models range from simple batch fermentations to complex multi-compartmental...
article 2013
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