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de Vries, H.J. (author), Pennings, H.J.M. (author), van der Schans, C.P. (author), Sanderman, R. (author), Oldenhuis, H.K.E. (author), Kamphuis, W. (author)
The effects of stress may be alleviated when its impact or a decreased stress-resilience are detected early. This study explores whether wearable-measured sleep and resting HRV in police officers can be predicted by stress-related Ecological Momentary Assessment (EMA) measures in preceding days and predict stress-related EMA outcomes in...
article 2023
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van der Kleij, R. (author)
Mensen spelen een belangrijke rol bij het ontstaan van cybersecurity-incidenten. Sommigen beweren zelfs dat de mens de primaire aanvalsvector is voor cybercriminelen. De medewerker vormt dan ook een groot risico voor organisaties. Oplossingen zijn veelal gericht op het voorkomen van ongewenste voorvallen door het implementeren van...
public lecture 2022
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Scholten, B. (author), Portengen, L. (author), Pronk, A. (author), Stierum, R. (author), Downward, G.S. (author), Vlaanderen, J. (author), Vermeulen, R. (author)
Background: Chemical risk assessment can benefit from integrating data across multiple evidence bases, especially in exposure–response curve (ERC) modeling when data across the exposure range are sparse. Methods: We estimated the ERC for benzene and acute myeloid leukemia (AML), by fitting linear and spline-based Bayesian meta-regression models...
article 2022
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Spini, G. (author), Mancini, E. (author), Attema, T. (author), Abspoel, M. (author), de Gier, J. (author), Fehr, S. (author), Veugen, T. (author), van Heesch, M. (author), Worm, D. (author), de Luca, A. (author), Cramer, R. (author), Sloot, P.M.A. (author)
BackgroundHIV treatment prescription is a complex process. Clinical decision support systems (CDSS) are a category of health information technologies that can assist clinicians to choose optimal treatments based on clinical trials and expert knowledge. The usability of some CDSSs for HIV treatment would be significantly improved by using the...
article 2022
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Suchowerska, A.K. (author), Stokman, G. (author), Palmer, J.T. (author), Coghlan, P.A. (author), Pieterman, E.J. (author), Keijzer, N. (author), Lambert, G. (author), Chemello, K. (author), Jaafar, A.K. (author), Parmar, J. (author), Yan, L. (author), Tong, Y. (author), Mu, L. (author), Princen, H.M.G. (author), Bonnar, J. (author), Evison, B.J. (author)
Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor (LDLR) and sending the receptor for lysosomal degradation. As the interaction promotes elevated plasma LDL-C levels, and therefore a predisposition to...
article 2022
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Albers, N. (author), Neerincx, M.A. (author), Brinkman, W.P. (author)
Behavior change applications often assign their users activities such as tracking the number of smoked cigarettes or planning a running route. To help a user complete these activities, an application can persuade them in many ways. For example, it may help the user create a plan or mention the experience of peers. Intuitively, the application...
article 2022
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Hogenelst, K. (author), Snippe, A. (author), Martinic, M. (author)
Aims. Harmful drinking patterns are shaped by a broad complex interaction of factors, societal and individual, psychological and behavioral. Although previous studies have focused on a few variables at a time, the current study simultaneously examines a large number of variables in order to create a comprehensive view (i.e. phenotype) of harmful...
article 2022
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Olga, L. (author), Bobeldijk-Pastorova, I. (author), Bas R.C., (author), Seidel, F. (author), Snowden, S.G. (author), Furse, S. (author), Ong, K.K. (author), Kleemann, R. (author), Koulman, A. (author)
This protocol outlines a translational lipidomic approach to discover lipid biomarkers that could predict morphometric body and histological organ measurements (e.g., weight and adiposity gains) during specific stages of life (e.g., early life). We describe procedures ranging from animal experimentation and histological analyses to downstream...
article 2022
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Bongers, C.C.W.G. (author), de Korte, J.Q. (author), Zwartkruis, M. (author), Levels, K. (author), Kingma, B.R.M. (author), Eijsvogels, T.M.H. (author)
The combination of an exacerbated workload and impermeable nature of the personal protective equipment (PPE) worn by COVID-19 healthcare workers increases heat strain. We aimed to compare the prevalence of heat strain symptoms before (routine care without PPE) versus during the COVID-19 pandemic (COVID-19 care with PPE), identify risk factors...
article 2022
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Komninos, D. (author), Ramos, L. (author), van der Heijden, G.W. (author), Morrison, M.C. (author), Kleemann, R. (author), van Herwaarden, A.E. (author), Kiliaan, A.J. (author), Arnoldussen, I.A.C. (author)
Obesity can disturb spermatogenesis and subsequently affect male fertility and reproduction. In our study, we aim to elucidate at which cellular level of adult spermatogenesis the detrimental effects of obesity manifest. We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr−/−.Leiden) mice, and studied...
article 2022
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Regeer, H. (author), van Empelen, P. (author), Bilo, H.J.G. (author), de Koning, E.J.P. (author), Huisman, S.D. (author)
Objective. To examine the relationship between risk factors for low patient activation and change in patient activation, well-being, and health outcomes in people with type 2 diabetes mellitus (T2DM). Method. A longitudinal prospective study was conducted with measurements at baseline and 20-week follow-up among 603 people with T2DM...
article 2022
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Kamphorst, B. (author), Rooijakkers, T. (author), Veugen, T. (author), Cellamare, M. (author), Knoors, D. (author)
article 2022
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Ostendorf, R. (author), Erpelinck, S. (author)
The Organ-on-a-Chip Early Research Program enables TNO to offer state-of-the-art technologies that help the pharmaceutical industry advance drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model human tissue functioning and accelerate compound development and testing. The Intestinal Epithelial Barrier...
other 2022
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Ostendorf, R. (author)
The Organ-on-a-Chip Early Research Program (ERP) has enabled TNO to offer a number of state-of-the-art technologies to help pharmaceutical and biotech companies advance and accelerate drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model the workings of human tissue and accelerate compound development...
other 2022
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McKeown, N.M. (author), Jr Fahey, G.C. (author), Slavin, J. (author), van der Kamp, J.W. (author)
[No abstract available]Chemicals / CAS Dietary Fiber.
article 2022
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Li, L. (author), Hoefsloot, H. (author), de Graaf, A.A. (author), Acar, E. (author), Smilde, A.K. (author)
Background: Analysis of dynamic metabolomics data holds the promise to improve our understanding of underlying mechanisms in metabolism. For example, it may detect changes in metabolism due to the onset of a disease. Dynamic or time-resolved metabolomics data can be arranged as a three-way array with entries organized according to a subjects...
article 2022
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Krishnan, S. (author), Vermeulen, R. (author), Pronk, A. (author), Gyori, B.M. (author), Bachman, J.A. (author), Vlaanderen, J. (author), Stierum, R. (author)
BACKGROUND: Mechanistic data is increasingly used in hazard identification of chemicals. However, the volume of data is large, challenging the efficient identification and clustering of relevant data. OBJECTIVES: We investigated whether evidence identification for hazard assessment can become more efficient and informed through an automated...
article 2022
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Scheerman, J.F.M. (author), van Meijel, B. (author), van Empelen, P. (author), Verrips, G.H.W. (author), van Loveren, C. (author), Twisk, J.W.R. (author), Pakpour, A.H. (author), van den Braak, M.C.T. (author), Kramer, G.J.C. (author)
[No abstract available]
article 2021
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Kocevska, D. (author), Lysen, T.S. (author), Dotinga, A. (author), Koopman-Verhoeff, M.E. (author), Luijk, M.P.C.M. (author), Antypa, N. (author), Biermasz, N.R. (author), Blokstra, A. (author), Brug, J. (author), Burk, W.J. (author), Comijs, H.C. (author), Corpeleijn, E. (author), Dashti, H.S. (author), de Bruin, E.J. (author), de Graaf, R. (author), Derks, I.P.M. (author), Dewald-Kaufmann, J.F. (author), Elders, P.J.M. (author), Gemke, R.J.B.J. (author), Grievink, L. (author), Hale, L. (author), Hartman, C.A. (author), Heijnen, C.J. (author), Huisman, M. (author), Huss, A. (author), Ikram, M.A. (author), Jones, S.E. (author), Klein Velderman, M. (author), Koning, M. (author), Meijer, A.M. (author), Meijer, K. (author), Noordam, R. (author), Oldehinkel, A.J. (author), Groeniger, J.O. (author), Penninx, B.W.J.H. (author), Picavet, H.S.J. (author), Pieters, S. (author), Reijneveld, S.A. (author), Reitz, E. (author), Renders, C.M. (author), Rodenburg, G. (author), Rutters, F. (author), Smith, M.C. (author), Singh, A.S. (author), Snijder, M.B. (author), Stronks, K. (author), ten Have, M, (author), Twisk, J.W.R. (author), van de Mheen, D. (author), van der Ende, J. (author), van der Heijden, K.B. (author), van der Velden, P.G. (author), van Lenthe, F.J. (author), van Litsenburg, R.R.L (author), van Oostrom, S.H. (author), van Schalkwijk, F.J. (author), Sheehan, CM, (author), Verheij, RA, (author), Verhulst, F.C. (author), Vermeulen, M.C.M. (author), Vermeulen, R.C.H. (author), Verschuren, W.M.M. (author), Vrijkotte, T.G.M. (author), Wijga, A.H. (author), Willemen, A.M. (author), ter Wolbeek, M. (author), Wood, A.R. (author), Xerxa, Y. (author), Bramer, W.M. (author), Franco, O.H. (author), Luik, A.I. (author), van Someren, E.J.W. (author), Tiemeier, H. (author)
We aimed to obtain reliable reference charts for sleep duration, estimate the prevalence of sleep complaints across the lifespan and identify risk indicators of poor sleep. Studies were identified through systematic literature search in Embase, Medline and Web of Science (9 August 2019) and through personal contacts. Eligible studies had to be...
article 2021
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Michaud, P.A. (author), Vervoort, J.P.M. (author), Visser, A. (author), Baltag, V. (author), Reijneveld, S.A. (author), Kocken, P. (author), Jansen, D.E.M.C. (author)
Background: School health services (SHS) can be defined as health services provided to enrol pupils by health professionals and/or allied professions. The aim of this study was to explore the current state of the governance, organization and workforce of SHS and their provision of preventive activities in European countries. Methods:...
article 2021
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