Searched for: subject:"von%5C+Willebrand%5C+Factor"
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Alizadeh Dehnavi, R. (author), Beishuizen, E.D. (author), van de Ree, M.A. (author), Le Cessie, S. (author), Huisman, M.V. (author), Kluft, C. (author), Princen, H.M.G. (author), Tamsma, J.T. (author), TNO Kwaliteit van Leven (author)
Background: The burden of cardiovascular disease in diabetes mellitus type 2 (DM2) patients is variable. We hypothesize that metabolic syndrome (MS) and low-grade systemic inflammation modify the extent of atherosclerosis in DM2. Methods: Vascular phenotype was determined using the following endothelium-related, hemostatic, and sonographic...
article 2008
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Emeis, J.J. (author), Jirouskova, M. (author), Muchitsch, E.-M. (author), Shet, A.S. (author), Smyth, S.S. (author), Johnson, G.J. (author), TNO Preventie en Gezondheid (author)
Murine blood coagulation factors and function are quite similar to those of humans. Because of this similarity and the adaptability of mice to genetic manipulation, murine coagulation factors and inhibitors have been extensively studied. These studies have provided significant insights into human hemostasis. They have also provided useful...
article 2007
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Spijkerman, A.M.W. (author), Gall, M.A. (author), Tarnow, L. (author), Twisk, J.W.R. (author), Lauritzen, E. (author), Lund-Andersen, H. (author), Emeis, J. (author), Parving, H.H. (author), Stehouwer, C.D.A. (author), TNO Kwaliteit van Leven (author)
Aims: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. Methods: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during the last 7 years. Retinopathy was assessed after...
article 2007
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de Lange, M. (author), de Geus, E.J.C. (author), Kluft, C. (author), Meijer, P. (author), van Doornen, L.J.P. (author), Boomsma, D.I. (author), Snieder, H. (author), TNO Kwaliteit van Leven (author)
Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in...
article 2006
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Espirito Santo, S.M.S. (author), Pires, N.M.M. (author), Boesten, L.S.M. (author), Gerritsen, G. (author), Bovenschen, N. (author), van Dijk, K.W. (author), Jukema, J.W. (author), Princen, H.M.G. (author), Bensadoun, A. (author), Li, W.P. (author), Herz, J. (author), Havekes, L.M. (author), van Vlijmen, B.J.M. (author), Gaubius Instituut TNO (author)
The low-density lipoprotein (LDL) receptor-related protein (LRP) has a well-established role in the hepatic removal of atherogenic apolipoprotein E (APOE)-rich remnant lipoproteins from plasma. In addition, LRP recognizes multiple distinct pro- and antiatherogenic ligands in vitro. Here, we investigated the role of hepatic LRP in atherogenesis...
article 2004
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van de Ree, M.A. (author), de Maat, M.P. (author), Kluft, C. (author), Meinders, A.E. (author), Princen, H.M. (author), Huisman, M.V. (author), Gaubius Instituut TNO (author)
BACKGROUND: Patients with Type 2 diabetes mellitus have increased levels of hemostatic risk variables for cardiovascular disease, such as fibrinogen, von Willebrand factor (VWF), factor (F)VIIa, d-dimer and plasminogen activator inhibitor-1 (PAI-1). OBJECTIVES: To evaluate the effect of aggressive vs. standard dose atorvastatin on hemostatic...
article 2003
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Becker, A. (author), van Hinsbergh, V.W.M. (author), Kostense, P.J. (author), Jager, A. (author), Dekker, J.M. (author), Nijpels, G. (author), Heine, R.J. (author), Bouter, L.M. (author), Stehouwer, C.D.A. (author), TNO Preventie en Gezondheid (author)
Background: Hyperhomocysteinaemia may constitute an independent risk factor for cardiovascular disease, but it is still unclear by which pathophysiological mechanisms homocysteine (tHcy) may promote atherothrombosis. The aim of this study was firstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of...
article 2000
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Yudkin, J.S. (author), Panahloo, A. (author), Stehouwer, C. (author), Emeis, J.J. (author), Bulmer, K. (author), Mohamed-Ali, V. (author), Denver, A.E. (author), Gaubius Instituut TNO (author)
Aims/hypothesis. Improved glycaemic control might reduce both microvascular and macrovascular complications of Type II diabetes (non-insulin-dependent) mellitus. To explore such possible mechanisms, we investigated the effects of intensive treatment on markers of endothelial dysfunction and of acute phase activation, using both sulphonylureas...
article 2000
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Schalkwijk, C.G. (author), Poland, D.C.W. (author), van Dijk, W. (author), Kok, A. (author), Emeis, J.J. (author), Dräger, A.M. (author), Doni, A. (author), van Hinsbergh, V.W.M. (author), Stehouwer, C.D.A. (author), Gaubius instituut TNO (author)
Moderately increased plasma concentrations of C-reactive protein are associated with an increased risk of cardiovascular disease, C-reactive protein, its relation to a low degree of inflammatory activation and its association with activation of the endothelium have not been systematically investigated in Type I (insulin-dependent) diabetes...
article 1999
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van Baal, W.M. (author), Kenemans, P. (author), Emeis, J.J. (author), Schalkwijk, C.G. (author), Mijatovic, V. (author), van der Mooren, M.J. (author), Vischer, U.M. (author), Stehouwer, C.D.A. (author), Gaubius instituut TNO (author)
Objective: To study the effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity. Design: Prospective, randomized, controlled study. Setting: Academic hospital. Patient(s): Healthy postmenopausal women with an intact uterus. Intervention(s): For the first 12 months, the hormone replacement...
article 1999
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Jager, A. (author), van Hinsbergh, V.W.M. (author), Kostense, P.J. (author), Emeis, J.J. (author), Yudkin, J.S. (author), Nijpels, G. (author), Dekker, J.M. (author), Heine, R.J. (author), Bouter, L.M. (author), Stehouwer, C.D.A. (author), Gaubius instituut TNO (author)
Increased levels of von Willebrand factor (vWf) and C-reactive protein (CRP) predict cardiovascular mortality in selected populations. It is uncertain whether vWf and CRP predict mortality in a general population and whether vWf and CRP predict mortality through similar pathways. This study investigated the association of vWf and CRP with...
article 1999
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Hegeman, R.J. (author), van den Eijnden-Schrauwen, Y. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The effect of compounds increasing intracellular adenosine 3':5'cyclic monophosphate [cAMP](i) levels (prostacyclin. isoproterenol, forskolin, cholera toxin), and of the cAMP analogs 8-bromo-cAMP and dibutyrpl-cAMP, on the regulated secretion (acute release) of tissue-type plasminogen activator (tPA) and von Willebrand factor (vWF) was studied...
article 1998
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Fioretto, P. (author), Stehouwer, C.D.A. (author), Mauer, M. (author), Chiesura-Corona, M. (author), Brocco, E. (author), Carraro, A. (author), Bortoloso, E. (author), van Hinsbergh, V.W.M. (author), Crepaldi, G. (author), Nosadini, R. (author), Gaubius Instituut TNO (author)
Microalbuminuria (MA) is associated with microangiopathy (renal and retinal lesions) in insulin-dependent diabetic (IDDM) patients. In contrast MA does not reflect microvascular damage in a substantial number of non- insulin-dependent diabetic (NIDDM) patients. MA predicts cardiovascular disease in NIDDM patients with increased von Willebrand...
article 1998
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Smulders, R.A. (author), Stehouwer, C.D.A. (author), Schalkwijk, C.G. (author), Donker, A.J.M. (author), van Hinsbergh, V.W.M. (author), TeKoppele, J.M. (author), TNO Preventie en Gezondheid (author)
Dysfunction of the vascular endothelium is considered an early step in the development of diabetic angiopathy. Hyperglycaemia results in endothelial dysfunction, both through direct effects of glucose and through formation of advanced glycosylation end-products (AGEs). We hypothesized that the effects of glucose and AGEs on endothelial function...
article 1998
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van Kesteren, P.J.M. (author), Kooistra, T. (author), Lansink, M. (author), van Kamp, G.J. (author), Asscheman, H. (author), Gooren, L.J.G. (author), Emeis, J.J. (author), Vischer, U.M. (author), Stehouwer, C.D.A. (author), Gaubius Instituut TNO (author)
We studied thirteen male-to-female (M→F) and ten female-to-male (F→M) transsexuals who, for four months, received cross-sex treatment with, respectively, ethinylestradiol and cyproterone acetate, and with testosterone esters. We assessed the effects of treatment on plasma levels of tissue-type plasminogen activator (tPA), von Willebrand factor ...
article 1998
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Myrup, B. (author), Jensen, T. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Deckert, T. (author), Gaubius Instituut TNO (author)
OBJECTIVE - The high risk for cardiovascular disease in IDDM patients with nephropathy may be mediated by abnormal function of the vascular wall. We investigated whether heparin was able to modulate markers of vascular wall and hemostatic function in patients with incipient nephropathy. RESEARCH DESIGN AND METHODS - Thirty-five IDDM patients...
article 1997
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van den Eijnden-Schrauwen, Y. (author), Atsma, D.E. (author), Lupu, F. (author), de Vries, R.E.M. (author), Kooistra, T. (author), Emeis, J.J. (author), TNO Preventie en Gezondheid (author)
In this study, we investigated the role of Ca2+ and G proteins in thrombin-induced acute release (regulated secretion) of tissue-type plasminogen activator (TPA) and yon Willebrand factor (vWF), using a previously described system of primary human umbilical vein endothelial cells (HUVECs). The acute release of TPA and vWF, as induced by α...
article 1997
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de Jong, S.C. (author), Stehouwer, C.D.A. (author), van den Berg, M. (author), Vischer, U.M. (author), Rauwerda, J.A. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
Hyperhomocysteinemia is associated with severe, premature atherosclerosis and thromboembolism. The mechanisms involved in the atherogenic and thrombotic complications of hyperhomocysteinemia are not understood. It has been suggested that hyperhomocysteinemia predisposes to atherosclerosis by injuring the vascular endothelium. Whether...
article 1997
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Gaubius Instituut TNO (author), Emeis, J.J. (author), Eijnden van den - Schrauwen, Y. (author), van den Hoogen, C.M. (author), de Priester, W. (author), Westmuckett, A. (author), Lupu, F. (author)
In previous studies we have shown that, after stimulation by a receptor ligand such as thrombin, tissue-type plasminogen activator (tPA) and von Willebrand factor (vW(f)) will be acutely released from human umbilical vein endothelial cells (HUVEC). However, the mechanisms involved in the secretion of these two proteins differ in some respects,...
article 1997
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Juhan-Vague, I. (author), Pyke, S.D.M. (author), Alessi, M.C. (author), Jespersen, J. (author), Haverkate, F. (author), Thompson, S.G. (author), Hematology Laboratory, CHU Timone, Marseille, France Medical Statistics Unit, London (UK) Sch. of Hyg./Trop. Med. Centralsygehuset, Esbjerg, Denmark Gaubius Laboratory Hematology Laboratory, CHU Timone, 13385 Marseille Cedex 5, France TNO Preventie en Gezondheid (author)
Background: Disturbances of the fibrinolytic system that lead to decreased removal of fibrin deposits may be important risk factors for coronary thrombosis. There is as yet no consensus on the prognostic value of fibrinolytic parameters, which may be attributed in part to the choice of confounding variables controlled for. Methods and Results:...
article 1996
Searched for: subject:"von%5C+Willebrand%5C+Factor"
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