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Lindmark, B. (author), Li, X.Q. (author), Bhattacharya, C. (author), Housler, G. (author), Heijer, M. (author), Bragg, R.A. (author), Gränfors, M. (author), Pelay-Gimeno, M. (author), Vaes, W.H.J. (author), Menakuru, S. (author), Pizzato, P.E. (author), Ericsson, H. (author), Johansson, S. (author)An absorption, distribution, metabolism, and excretion study was performed to determine the basic pharmacokinetic parameters, mass balance, and metabolite profiles of balcinrenone, a mineralocorticoid receptor modulator, in humans. This open-label, single-center, nonrandomized study had a two-period design. In period 1, eight healthy male...article 2023
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Scharn, M. (author), Oude Hengel, K. (author), Boot, C.R.L. (author), Burdorf, A. (author), Schuring, M. (author), van der Beek, A.J. (author), Robroek, S.J.W. (author)Background This study aims to provide insight into the associations between having a chronic disease and participation in paid work, volunteer activities or informal care, the associations between the onset of a chronic disease and these forms of societal participation, and whether these associations differ across educational level and gender....article 2019
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Oerlemans, A. (author), Verscheijden, L.F.M. (author), Mol, J.G.J. (author), Vermeulen, R.C.H. (author), Westerhout, J. (author), Roeleveld, N. (author), Russel, F.G.M. (author), Scheepers, P.T.J. (author)Tebuconazole (TEB) is a widely used triazole fungicide, but the toxicokinetics of its human metabolites are not fully described. For proper interpretation of biological monitoring data, knowledge on the metabolism and elimination of the compound is required. A human volunteer study was performed with the aim to describe the time courses of...article 2019
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de Ligt, R. (author), van Duijn, E. (author), Grossouw, D. (author), Bosgra, S. (author), Burggraaf, J. (author), Windhorst, A. (author), Peeters, P.A.M. (author), van der Luijt, G.A. (author), Alexander-White, C. (author), Vaes, W.H.J. (author)A clinical pharmacokinetic study was performed in 12 healthy women to evaluate systemic exposure to aluminum following topical application of a representative antiperspirant formulation under real-life use conditions. A simple roll-on formulation containing an extremely rare isotope of aluminum (26 Al) chlorohydrate (ACH) was prepared to...article 2018
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Vlaming, M.L. (author), van Duijn, E. (author), Dillingh, M.R. (author), Brands, R. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Bosgra, S. (author), Burggraaf, J. (author), de Koning, M.C. (author), Fidder, A. (author), Mocking, J.A. (author), Sandman, H. (author), de Ligt, R.A. (author), Fabriek, B.O. (author), Pasman, W.J. (author), Seinen, W. (author), Alves, T. (author), Carrondo, M. (author), Peixoto, C. (author), Peeters, P.A. (author), Vaes, W.H. (author)Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show for the first time that pharmacokinetic data of NBEs in humans can be successfully obtained early...article 2015
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van Rooij, L. (author), Elrofai, H.B.H. (author), Philippens, M.M.G.M. (author), Daanen, H.A.M. (author)It is important to understand human kinematics and muscle activation patterns in emergency maneuvers for the design of safety systems and for the further development of human models. The objective of this study was to quantify kinematic behavior and muscle activation in simulated steering tests in several realistic conditions. In total 108 tests...article 2013
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Ioannis, S. (author), Kavadarli, G. (author), Fraga, F. (author), van Rooij, L. (author), Schuller, E. (author), Peldschus, S. (author)Motorcycle braking experiments with volunteers were performed in lab, to study the body posture and reactions of the motorcyclists during braking with the aim of providing input for human modelling. Human motion capture methods were employed for the kinematics and the recorded data was further analyzed with clustering methods for time-series....conference paper 2010
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Berger, M.A.M. (author), Krul, A. (author), Daanen, H.A.M. (author), TNO Defensie en Veiligheid (author)Finger dexterity tests are generally used to assess performance decrease due to gloves, cold and pathology. It is generally assumed that the OConnor and Purdue Pegboard test yield similar results. In this experiment we compared these two tests for dry conditions without gloves, and for dry and wet conditions with two types of Nytril gloves. In...article 2009
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Hamer, H.M. (author), Jonkers, D.M.A.E. (author), Loof, A. (author), van Houtvin, S.A.L.W. (author), Troost, F.J. (author), Venema, K. (author), Kodde, A. (author), Koek, G.H. (author), Schipper, R.G. (author), van Heerde, W.L. (author), Brummer, R.J. (author), TNO Kwaliteit van Leven (author)Background: The mucus layer is an important dynamic component of the epithelial barrier. It contains mucin glycoproteins and other compounds secreted by the intestinal epithelium, such as secretory IgA. However, a standardized in vivo sampling technique of mucus in humans is not yet available. Aim: To assess the validity and feasibility of mucin...article 2009
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Wismans, J.S.H.M. (author), Meijer, R. (author), Rodarius, C. (author), Been, B.W. (author), TNO Industrie en Techniek (author)Neck biofidelity performance requirements for different sized crash dummies and human body computer models are usually based on scaling of performance requirements derived for a 50th percentile body size. The objective of this study is to investigate the validity of the currently used scaling laws for the human neck in case of side impacts....conference paper 2008
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van Doorn, M. (author), Vogels, J. (author), Tas, A. (author), van Hoogdalem, E.J. (author), Burggraaf, J. (author), Cohen, A. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)Aims: To explore the usefulness of metabolomics as a method to obtain a broad array of biomarkers for the pharmacological effects of rosiglitazone (RSG) in plasma and urine samples from patients with type 2 diabetes mellitus (T2DM) and healthy volunteers (HVs). Additionally, we explored the differences in metabolite concentrations between T2DM...article 2007
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van Vliet, T. (author), Jacobs, R.G.J.M. (author), de Deckere, E. (author), van den Berg, H. (author), de Bree, A. (author), van der Put, N.M.J. (author), TNO Kwaliteit van Leven (author)Objective: To determine the effect of folic acid, vitamin B6 and B12 fortified spreads on the blood concentrations of these vitamins and homocysteine. Design and setting: A 6-week randomized, double-blinded, placebo-controlled, parallel trial carried out in a clinical research center. Subjects: One hundred and fifty healthy volunteers (50% males...article 2007
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Guzik, P. (author), Piskorski, J. (author), Krauze, T. (author), Schneider, R. (author), Wesseling, K.H. (author), Wykrȩtowicz, A. (author), Wysocki, H. (author), TNO Biomedical Instrumentation (author)Aim: To analyze the correlation of the Poincaré plot descriptors of RR intervals with standard measures of heart rate variability (HRV) and spontaneous baroreflex sensitivity (BRS). A physiological model of changing respiratory rates from 6 to 15 breaths/min provided a wide range of RR intervals for analysis. Material and methods: Beat-to-beat...article 2007
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Meuling, W.J. (author), Ravensberg, L.C. (author), Roza, L. (author), van Hemmen, J.J. (author), TNO Kwaliteit van Leven (author)Objective: The methods and results are described of a study on the dermal absorption of chlorpyrifos (CPF) in humans established via urinary excretion of the metabolite 3,5,6-trichloro-2-pyridinol (TCP). Methods: Two dermal, single, doses of CPF were applied in two study groups (A and B) each comprising three apparently healthy male volunteers...article 2005
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de Jong, R.J. (author), Verwei, M. (author), West, C.E. (author), van Vliet, T. (author), Siebelink, E. (author), van den Berg, H. (author), Castenmiller, J.J.M. (author), TNO Kwaliteit van Leven (author)Objective: The aim of this study was to investigate whether milk fortified with folic acid enhances the folate status of humans and whether the presence of folate-binding proteins (FBP) in pasteurised milk affects the bioavailability of folic acid from fortified milk. In untreated and pasteurised milk, folate occurs bound to FBP, while FBP is ...article 2005
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Nohynek, G.J. (author), Skare, J.A. (author), Meuling, W.J.A. (author), Hein, D.W. (author), de Bie, A.T.H.J. (author), Toutain, H. (author), TNO Voeding (author)In the organism of mammals, important detoxification pathways of arylamines are catalysed by N-acetyltransferase 2 (NAT2). A recent case-control epidemiology study suggested that human NAT2 slow acetylators exposed to oxidative hair dyes may be at greater risk to develop bladder cancer. We therefore profiled urinary [14C]-metabolites and NAT2...article 2004
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Kezic, S. (author), Meuling, W.J.A. (author), Jakasa, I. (author), TNO Voeding (author)Objectives: To assess excretion kinetics of free and total (free + conjugated) 2-butoxyacetic acid (BAA) following dermal and inhalation exposure to butoxyethanol (BE). Methods: Six male volunteers were derma lly exposed for 4 h to a 50% aqueous solution of BE on an area of 40 cm2 of the volar forearm. Six other male volunteers were exposed by...article 2004
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Markus, C.R. (author), Sierksma, A. (author), Verbeek, C. (author), van Rooijen, J.J.M. (author), Patel, H.J. (author), Brand, A.N. (author), Hendriks, H.F.J. (author)Brain serotonin (5-HT) synthesis is controlled by nutrients that influence the availability of plasma tryptophan (Trp) as compared with the sum of the other large neutral amino acids (LNAA; Trp:LNAA). Alcohol consumption is found to change mood and performance and this might well be due to alterations in the plasma Trp:LNAA ratio and brain 5-HT....article 2004
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- Meijer, R. (author), Parenteau, C. (author), van Hoof, J.F.A.M. (author), Gopal, M. (author) conference paper 2003
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Emmen, H.H. (author), Muijser, H. (author), Arts, J.H.E. (author), Prinsen, M.K. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)The objective of this study was to establish the possible occurrence of eye irritation and subjective symptoms in human volunteers exposed to propylene glycol monomethyl ether (PGME) vapour at concentrations of 0, 100 and 150 ppm. Testing was conducted in 12 healthy male volunteers using a repeated measures design. Each subject was exposed for 2...article 2003
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