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Genkinger, J.M. (author), Wang, M. (author), Li, R. (author), Albanes, D. (author), Anderson, K.E. (author), Bernstein, L. (author), van den Brandt, P.A. (author), English, D.R. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Gapstur, S.M. (author), Giles, G.G. (author), Goldbohm, R.A. (author), Håkansson, N. (author), Horn-Ross, P.L. (author), Koushik, A. (author), Marshal, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Robien, K. (author), Rohan, T.E. (author), Schairer, C. (author), Silverman, D.T. (author), Stolzenberg-Solomon, R.Z. (author), Virtamo, J. (author), Willett, W.C. (author), Wolk, A. (author), Ziegler, R.G. (author), Smith-Warner, S.A. (author)Pancreatic cancer has few early symptoms, is usually diagnosed at late stages, and has a high case-fatality rate. Identifying modifiable risk factors is crucial to reducing pancreatic cancer morbidity and mortality. Prior studies have suggested that specific foods and nutrients, such as dairy products and constituents, may play a role in...article 2014
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TNO Kwaliteit van Leven (author), Molag, M.L. (author), de Vries, J.H.M. (author), Duif, N. (author), Ocké, M.C. (author), Dagnelie, P.C. (author), Goldbohm, R.A. (author), van 't Veer, P. (author)The authors automated the selection of foods in a computer system that compiles and processes tailored FFQ. For the selection of food items, several methods are available. The aim of the present study was to compare food lists made by MOM2, which identifies food items with highest between-person variance in intake of the nutrients of interest...article 2010
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van Dijk, C.E. (author), de Boer, M.R. (author), Koppes, L.L.J. (author), Roos, J.C. (author), Lips, P. (author), Twisk, J.W.R. (author), TNO Kwaliteit van Leven (author)Introduction: Studies on the association of vitamin D and bone mineral density (BMD) in adolescence and young adults have shown contrasting results. None of these studies have examined the course and baseline in vitamin D intake. The purpose of this study was to examine the association between baseline and the course of dietary vitamin D intake...article 2009
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de Vogel, S. (author), Bongaerts, B.W.C. (author), Wouters, K.A.D. (author), Kester, A.D.M. (author), Schouten, L.J. (author), de Goeij, A.F.P.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), van Engeland, M. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)Intake of dietary factors that serve as methyl group donors may influence promoter hypermethylation in colorectal carcinogenesis. We investigated whether dietary folate, vitamin B2 and vitamin B6, methionine and alcohol were associated with mutL homologue 1 (MLH1) hypermethylation and the related molecular phenotypes of MLH1 protein expression,...article 2008
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van Dijk, B.A.C. (author), Schouten, L.J. (author), Oosterwijk, E. (author), Kaa, C.A. (author), Kiemeney, L.A.L.M. (author), Goldbohm, R.A. (author), Schalken, J.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Objective: We investigated whether dietary carotenoid and vitamin intake and supplemental vitamin use were inversely associated with RCC risk and with Von Hippel-Lindau (VHL)-gene mutations in clear-cell renal cell carcinoma (RCC). Methods: The Netherlands Cohort Study on diet and cancer (NLCS) includes 120,852 persons, who completed a self...article 2008
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Cho, E. (author), Hunter, D.J. (author), Spiegelman, D. (author), Albanes, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Colditz, G.A. (author), Feskanich, D. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Rohan, T.E. (author), Sellers, T.A. (author), Virtamo, J. (author), Willett, W.C. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Intakes of vitamins A, C and E and folate have been hypothesized to reduce lung cancer risk. We examined these associations in a pooled analysis of the primary data from 8 prospective studies from North America and Europe. Baseline vitamin intake was assessed using a validated food-frequency questionnaire, in each study. We calculated study...article 2006
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de Vogel, S. (author), van Engeland, M. (author), Lüchtenborg, M. (author), de Bruïne, A.P. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), de Goeij, A.F.P.M. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)Folate deficiency has been associated with colorectal cancer risk and may be involved in colorectal carcinogenesis through increased chromosome instability, gene mutations, and aberrant DNA methylation. Within the Netherlands Cohort Study on diet and cancer, we investigated the associations between dietary folate intake and colorectal cancer...article 2006
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Lambert, J. (author), Agostoni, C. (author), Elmadfa, I. (author), Hulshof, K. (author), Krause, E. (author), Livingstone, B. (author), Socha, P. (author), Pannemans, D. (author), Samartín, S. (author)The objective of this project was to collect and evaluate data on nutrient intake and status across Europe and to ascertain whether any trends could be identified. Surveys of dietary intake and status were collected from across Europe by literature search and personal contact with country experts. Surveys that satisfied a defined set of criteria...article 2004
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Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigsLamers, R.-J.A.N. (author), de Groot, J. (author), Spies-Faber, E.J. (author), Jellema, R.H. (author), Kraus, V.B. (author), Verzijl, N. (author), te Koppele, J.M. (author), Spijksma, G.K. (author), Vogels, J.T.W.E. (author), van der Greef, J. (author), van Nesselrooij, J.H.J. (author)Osteoarthritis (OA), one of the most common diseases among the elderly, is characterized by the progressive destruction of joint tissues. Its etiology is largely unclear and no effective disease-modifying treatment is currently available. Metabolic fingerprinting provides a novel tool for the identification of biomarkers. A metabolic fingerprint...article 2003
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van der Pal-de Bruin, K.M. (author), de Walle, H.E.K. (author), de Rover, C.M. (author), Jeeninga, W. (author), Cornel, M.C. (author), de Jong-van den Berg, L.T.W. (author), Buitendijk, S.E. (author), Paulussen, T.G.W.M. (author), TNO Preventie en Gezondheid (author)In The Netherlands, periconceptional folic acid use to prevent neural tube defects was promoted through a national 'Folic Acid Campaign'. In two regions, a local campaign supplemented the national campaign to increase the chances of reaching women with low socio-economic status (SES). A framework of outcome criteria, defined as awareness...article 2003
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van der Gaag, M.S. (author), Ubbink, J.B. (author), Sillanaukee, P. (author), Nikkari, S. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Serum homocysteine increases after moderate consumption of red wine and spirits, but not after moderate consumption of beer. Vitamin B6 in beer seems to prevent the alcohol-induced rise in serum homocysteine. Chemicals/CAS: Homocysteine, 454-28-4; Pyridoxine, 65-23-6article 2000
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Brussaard, J.H. (author), van den Berg, H. (author), Hermus, R.J.J. (author), Walter, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To discuss the approach of the US Food and Nutrition Board (FNB) to daily nutrient requirements and its relevance for Europe. Setting: A workshop for experts from academia and regulatory bodies, together with members from the FNB Dietary Reference Intakes Subcommittee on Upper Reference Levels of Intake, and from the B-vitamins Expert...article 1999
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Hermus, R.J.J. (author), Severs, A.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)-Consumers increasingly use vitamin supplements. Also, since June 1996, foodstuffs enriched with vitamins are available on the Dutch market. -These sources of extra vitamins may be useful for groups at risk for marginal vitamin deficiencies. -These risk groups include the chronically ill (e.g. diabetics), people using medicaments, older people...article 1999
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), van den Berg, H. (author)Chemicals/CAS: Homocysteine, 454-28-4; Proteins; Pyridoxic Acid, 82-82-6; Pyridoxine, 65-23-6article 1999
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van Loon, A.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Study objective - To study the association between socioeconomic status (SES) and stomach cancer incidence (cardia and non-cardia) and the role of lifestyle factors in explaining this association. Design - Prospective cohort study on diet and cancer that started in 1986. Data were collected by means of a self administered questionnaire. Setting ...article 1998
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Weststrate, J.A. (author), van het Hof, K.H. (author), van den Berg, H. (author), te Velthuis-te-Wierik, E.J.M. (author), de Graaf, C. (author), Zimmermanns, N.J.H. (author), Westerterp, K.R. (author), Westerterp-Plantenga, M.S. (author), van de Verboeket-Venne, W.P.H.G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objectives: To compare the effects of free access to reduced fat products or their full fat equivalents on fat and energy intake, body weight, plasma lipids and fat-soluble antioxidants concentrations and haemostasis variables. Design: A multicentre open randomised controlled trial in which intervention and control groups were followed in...article 1998
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Löwik, M.R.H. (author), Hulshof, K.F.A.M. (author), van der Heijden, L.J.M. (author), Brussaard, J.H. (author), Burema, J. (author), Kistemaker, C. (author), de Vries, P.J.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)From April 1987-March 1988, the first Dutch National Food Consumption Survey (DNFCS) was carried out among 2203 households comprising 5898 subjects, aged 1-85. In 1992 (January-December) the second DNFCS was conducted among 6218 subjects, aged 1-92 belonging to 2475 households. In both surveys, among other things, information on individual food...article 1998
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van Poppel, G. (author), van den Berg, H. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)The prospect that high intake of certain vitamins may confer protection against cancer has drawn substantial attention during the last decades. This paper gives a concise update of the role of a number of promising vitamins in prevention of cancer. Vitamin A and its analogues have an important role in cellular processes related to carcinogenesis...article 1997
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- van den Berg, H. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author) article 1997
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te Velthuis- Wierik, E.J.M. (author), van den Berg, H. (author), Weststrate, J.A. (author), van het Hof, K.H. (author), de Graaf, C. (author), TNO Voeding (author)Objective: Dietary fat intake is higher than recommended in most western countries and is associated with the prevalence of cardiovascular diseases, obesity and cancer. The growing public concern about the adverse effects of a high fat intake has led to an increased availability of 'reduced-fat' products. Consumption of reduced-fat products...article 1996
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